A Rare Presentation of Checkpoint Inhibitor Induced Distal RTA
Immune checkpoint inhibitors have opened a new era in treating advanced malignancies, resulting in a rapid increase in utilization, given the remarkable clinical outcomes. The incidence of immune-related adverse events increased due to the immunologic effects of these therapeutic agents. However, im...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2021/7406911 |
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| author | Andrew V. Doodnauth Miriam M. Klar Zohra R. Malik Krunal H. Patel Samy I. McFarlane |
| author_facet | Andrew V. Doodnauth Miriam M. Klar Zohra R. Malik Krunal H. Patel Samy I. McFarlane |
| author_sort | Andrew V. Doodnauth |
| collection | DOAJ |
| description | Immune checkpoint inhibitors have opened a new era in treating advanced malignancies, resulting in a rapid increase in utilization, given the remarkable clinical outcomes. The incidence of immune-related adverse events increased due to the immunologic effects of these therapeutic agents. However, immune-related renal adverse events remain low, representing only a small incidence of reported cases. Common renal toxicity described includes acute interstitial nephritis, minimal change disease, and immune complex glomerulonephritis. Renal tubular acidosis has occasionally been reported but is highly uncommon. This report presents a case of a 68-year-old woman with a known history of metastatic melanoma undergoing treatment with ipilimumab+nivolumab, who developed distal renal tubular acidosis requiring stress dose steroids and sodium bicarbonate for treatment. We describe the clinical characteristics, potential mechanisms, and management of this case, highlighting the need among clinicians utilizing immune check inhibitors to be aware of this immune-related disease entity. |
| format | Article |
| id | doaj-art-7d6744ef5d054324bf7727c75045aba9 |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-7d6744ef5d054324bf7727c75045aba92025-02-03T05:44:45ZengWileyCase Reports in Oncological Medicine2090-67062090-67142021-01-01202110.1155/2021/74069117406911A Rare Presentation of Checkpoint Inhibitor Induced Distal RTAAndrew V. Doodnauth0Miriam M. Klar1Zohra R. Malik2Krunal H. Patel3Samy I. McFarlane4Department of Internal Medicine, State University of New York—Downstate Health Sciences University, Brooklyn, New York, 11203, USADepartment of Internal Medicine, State University of New York—Downstate Health Sciences University, Brooklyn, New York, 11203, USADepartment of Internal Medicine, St. John’s Episcopal Hospital, Far Rockaway, New York, 11691, USADepartment of Internal Medicine, State University of New York—Downstate Health Sciences University, Brooklyn, New York, 11203, USADepartment of Internal Medicine, State University of New York—Downstate Health Sciences University, Brooklyn, New York, 11203, USAImmune checkpoint inhibitors have opened a new era in treating advanced malignancies, resulting in a rapid increase in utilization, given the remarkable clinical outcomes. The incidence of immune-related adverse events increased due to the immunologic effects of these therapeutic agents. However, immune-related renal adverse events remain low, representing only a small incidence of reported cases. Common renal toxicity described includes acute interstitial nephritis, minimal change disease, and immune complex glomerulonephritis. Renal tubular acidosis has occasionally been reported but is highly uncommon. This report presents a case of a 68-year-old woman with a known history of metastatic melanoma undergoing treatment with ipilimumab+nivolumab, who developed distal renal tubular acidosis requiring stress dose steroids and sodium bicarbonate for treatment. We describe the clinical characteristics, potential mechanisms, and management of this case, highlighting the need among clinicians utilizing immune check inhibitors to be aware of this immune-related disease entity.http://dx.doi.org/10.1155/2021/7406911 |
| spellingShingle | Andrew V. Doodnauth Miriam M. Klar Zohra R. Malik Krunal H. Patel Samy I. McFarlane A Rare Presentation of Checkpoint Inhibitor Induced Distal RTA Case Reports in Oncological Medicine |
| title | A Rare Presentation of Checkpoint Inhibitor Induced Distal RTA |
| title_full | A Rare Presentation of Checkpoint Inhibitor Induced Distal RTA |
| title_fullStr | A Rare Presentation of Checkpoint Inhibitor Induced Distal RTA |
| title_full_unstemmed | A Rare Presentation of Checkpoint Inhibitor Induced Distal RTA |
| title_short | A Rare Presentation of Checkpoint Inhibitor Induced Distal RTA |
| title_sort | rare presentation of checkpoint inhibitor induced distal rta |
| url | http://dx.doi.org/10.1155/2021/7406911 |
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