Large-scale functional network connectivity mediate the associations of white matter lesions with executive functions and information processing speed in asymptomatic cerebral small vessels diseases
Objective: To examine the role of the large-scale functional network connectivity between white matter lesions (WMLs) and cognitive behaviors in patients of asymptomatic cerebral small vascular diseases (CSVD). Methods: The study sample consisted of 211 asymptomatic CSVD patients with WMLs. Large-sc...
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Elsevier
2025-01-01
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| Series: | NeuroImage: Clinical |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158225000439 |
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| author | Jing Chen Weiwei lu Zhangyang Wang Mingfang Shi Zhang Shi Weibin Shi |
| author_facet | Jing Chen Weiwei lu Zhangyang Wang Mingfang Shi Zhang Shi Weibin Shi |
| author_sort | Jing Chen |
| collection | DOAJ |
| description | Objective: To examine the role of the large-scale functional network connectivity between white matter lesions (WMLs) and cognitive behaviors in patients of asymptomatic cerebral small vascular diseases (CSVD). Methods: The study sample consisted of 211 asymptomatic CSVD patients with WMLs. Large-scale internetwork and intranetwork functional connectivity (FC) were calculated using a combination of resting-state functional MRI data and independent component analysis. Neuropsychological tests involve cognitive functions were also measured. Then, potential correlations between WMLs, functional network connectivity and cognitive behaviors were tested. Mediation analysis was used to explore the role of functional network connectivity between WMLs and cognitive behaviors. Results: We successfully identified fourteen meaningful resting-state functional networks. Internetwork FC between dorsal sensorimotor network (dSMN) and right frontoparietal network (rFPN), dSMN and left frontoparietal network (lFPN), auditory network (AN) and posterior default network (pDMN), AN and executive control network (ECN), ECN and salience network (SN), dorsal attention network (DAN) and ECN were significant correlated with volumes of WMLs. Executive function were associated with internetwork FC between AN and pDMN, ECN and SN. Moreover, internetwork FC between AN and pDMN, ECN and SN mediated the relations of WMLs with executive function (for AN and pDMN, indirect effect: −0.0371, 95% CI: −0.0829 to −0.0073; for ECN and SN, indirect effect: −0.03191, 95% CI: −0.0807 to −0.0047). Moreover, left inferior parietal lobule in rFPN, right precentral gyrus in anterior default network (aDMN), right paracentral lobue in pDMN and left precunues in ECN were related to volumes of WMLs. There is a significant association of WMLs with intranetwork FC in left precunues, which could mediate the link between WMLs and information processing speed (indirect effect: −0.0437, 95% CI: −0.1055 to −0.0081). Conclusion: WMLs in asymptomatic CSVD patients may induce large-scale connectivity changes including the internetwork FC and intranetwork FC, which might further influence executive function and information processing speed. |
| format | Article |
| id | doaj-art-7d658f5bc1a448f9b6830ab2b35c47fb |
| institution | DOAJ |
| issn | 2213-1582 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
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| series | NeuroImage: Clinical |
| spelling | doaj-art-7d658f5bc1a448f9b6830ab2b35c47fb2025-08-20T03:19:56ZengElsevierNeuroImage: Clinical2213-15822025-01-014610377310.1016/j.nicl.2025.103773Large-scale functional network connectivity mediate the associations of white matter lesions with executive functions and information processing speed in asymptomatic cerebral small vessels diseasesJing Chen0Weiwei lu1Zhangyang Wang2Mingfang Shi3Zhang Shi4Weibin Shi5Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, China; Correspondence author.Department of Rehabilitation, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Neurology, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Rehabilitation, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Radiology, Zhongshan Hospital, Fudan University, Shanghai, ChinaHealth Examination Center, Zhongshan Hospital, Fudan University, Shanghai, ChinaObjective: To examine the role of the large-scale functional network connectivity between white matter lesions (WMLs) and cognitive behaviors in patients of asymptomatic cerebral small vascular diseases (CSVD). Methods: The study sample consisted of 211 asymptomatic CSVD patients with WMLs. Large-scale internetwork and intranetwork functional connectivity (FC) were calculated using a combination of resting-state functional MRI data and independent component analysis. Neuropsychological tests involve cognitive functions were also measured. Then, potential correlations between WMLs, functional network connectivity and cognitive behaviors were tested. Mediation analysis was used to explore the role of functional network connectivity between WMLs and cognitive behaviors. Results: We successfully identified fourteen meaningful resting-state functional networks. Internetwork FC between dorsal sensorimotor network (dSMN) and right frontoparietal network (rFPN), dSMN and left frontoparietal network (lFPN), auditory network (AN) and posterior default network (pDMN), AN and executive control network (ECN), ECN and salience network (SN), dorsal attention network (DAN) and ECN were significant correlated with volumes of WMLs. Executive function were associated with internetwork FC between AN and pDMN, ECN and SN. Moreover, internetwork FC between AN and pDMN, ECN and SN mediated the relations of WMLs with executive function (for AN and pDMN, indirect effect: −0.0371, 95% CI: −0.0829 to −0.0073; for ECN and SN, indirect effect: −0.03191, 95% CI: −0.0807 to −0.0047). Moreover, left inferior parietal lobule in rFPN, right precentral gyrus in anterior default network (aDMN), right paracentral lobue in pDMN and left precunues in ECN were related to volumes of WMLs. There is a significant association of WMLs with intranetwork FC in left precunues, which could mediate the link between WMLs and information processing speed (indirect effect: −0.0437, 95% CI: −0.1055 to −0.0081). Conclusion: WMLs in asymptomatic CSVD patients may induce large-scale connectivity changes including the internetwork FC and intranetwork FC, which might further influence executive function and information processing speed.http://www.sciencedirect.com/science/article/pii/S2213158225000439Large-scale brain networksFunctional connectivityWhite matter lesionsFunctional magnetic resonance imagingExecutive functionsInformation processing speed |
| spellingShingle | Jing Chen Weiwei lu Zhangyang Wang Mingfang Shi Zhang Shi Weibin Shi Large-scale functional network connectivity mediate the associations of white matter lesions with executive functions and information processing speed in asymptomatic cerebral small vessels diseases NeuroImage: Clinical Large-scale brain networks Functional connectivity White matter lesions Functional magnetic resonance imaging Executive functions Information processing speed |
| title | Large-scale functional network connectivity mediate the associations of white matter lesions with executive functions and information processing speed in asymptomatic cerebral small vessels diseases |
| title_full | Large-scale functional network connectivity mediate the associations of white matter lesions with executive functions and information processing speed in asymptomatic cerebral small vessels diseases |
| title_fullStr | Large-scale functional network connectivity mediate the associations of white matter lesions with executive functions and information processing speed in asymptomatic cerebral small vessels diseases |
| title_full_unstemmed | Large-scale functional network connectivity mediate the associations of white matter lesions with executive functions and information processing speed in asymptomatic cerebral small vessels diseases |
| title_short | Large-scale functional network connectivity mediate the associations of white matter lesions with executive functions and information processing speed in asymptomatic cerebral small vessels diseases |
| title_sort | large scale functional network connectivity mediate the associations of white matter lesions with executive functions and information processing speed in asymptomatic cerebral small vessels diseases |
| topic | Large-scale brain networks Functional connectivity White matter lesions Functional magnetic resonance imaging Executive functions Information processing speed |
| url | http://www.sciencedirect.com/science/article/pii/S2213158225000439 |
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