Enhanced bone regeneration using sodium alginate and polyvinyl alcohol incorporating TiO2 nanoparticles composite film for orthopedic application
Bone tissue regeneration remains a significant challenge in orthopedic medicine due to the limited osteogenic and antimicrobial properties of conventional biomaterials. This study presents an innovative approach to prepare nanocomposite film involving sodium alginate (SA) and polyvinyl alcohol (PVA)...
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Elsevier
2025-01-01
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| Series: | Results in Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715625000323 |
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| author | Guoying Zhang Xunkai Hou Zhen Geng Mahani Yusoff Nur Adibah Roslan Mohd Hasmizam Razali |
| author_facet | Guoying Zhang Xunkai Hou Zhen Geng Mahani Yusoff Nur Adibah Roslan Mohd Hasmizam Razali |
| author_sort | Guoying Zhang |
| collection | DOAJ |
| description | Bone tissue regeneration remains a significant challenge in orthopedic medicine due to the limited osteogenic and antimicrobial properties of conventional biomaterials. This study presents an innovative approach to prepare nanocomposite film involving sodium alginate (SA) and polyvinyl alcohol (PVA) blend polymers reinforced with titanium dioxide nanoparticles (TiO2NPs) at varying concentrations (0 wt%, 1 wt%, 5 wt%, 10 wt, and 15 wt%) using solvent casting method. Among these, the PVA + SA@10 wt%TiO2NPs nanocomposite film exhibited exceptional bioactivity and antibacterial properties, positioning it as a promising candidate for bone tissue engineering. Notably, hydroxyapatite (HA) formation was observed within 7 days of immersing the nanocomposite film in simulated body fluid (SBF), effectively mimicking natural bone mineralization. The PVA + SA@10 wt%TiO2NPs nanocomposite demonstrated potent antibacterial activity against S. aureus and E. coli, along with excellent cytocompatibility with MG-63 cells. Advanced characterization techniques, including FTIR, SEM, XRD, and analyses of swelling and porosity, confirmed significant improvements in physicochemical properties, supporting the superior performance of this composite. This scalable, cost-effective material holds substantial potential for advancing regenerative medicine by addressing critical orthopaedic challenges and offering a sustainable solution for bone tissue repair. The novelty of this work lies in the development of the PVA + SA@TiO2NPs composite film, specifically designed to enhance bone regeneration for orthopaedic applications. |
| format | Article |
| id | doaj-art-7d6087b9918a4e188112754f3fd291c7 |
| institution | Kabale University |
| issn | 2211-7156 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
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| series | Results in Chemistry |
| spelling | doaj-art-7d6087b9918a4e188112754f3fd291c72025-01-29T05:01:08ZengElsevierResults in Chemistry2211-71562025-01-0113102049Enhanced bone regeneration using sodium alginate and polyvinyl alcohol incorporating TiO2 nanoparticles composite film for orthopedic applicationGuoying Zhang0Xunkai Hou1Zhen Geng2Mahani Yusoff3Nur Adibah Roslan4Mohd Hasmizam Razali5Department of Trauma and Hand and Foot Surgery, Shandong Provincial Third Hospital, Shandong University, Jinan 250031 ChinaDepartment of Trauma and Hand and Foot Surgery, Shandong Provincial Third Hospital, Shandong University, Jinan 250031 China; Corresponding authors.Department of Joint and Sports Medicine Surgery, Shandong Provincial Third Hospital, Shandong University, Jinan 250031 China; Corresponding authors.Faculty of Bioengineering and Technology, Universiti Malaysia Kelantan Kampus Jeli 17600 Jeli, Kelantan, MalaysiaFaculty of Science and Marine Environment, Universiti Malaysia Terengganu, 21030 Kuala Nerus, Terengganu, MalaysiaFaculty of Science and Marine Environment, Universiti Malaysia Terengganu, 21030 Kuala Nerus, Terengganu, Malaysia; Advanced Nanomaterials Research Group, Faculty of Science and Marine Environment, Universiti Malaysia Terengganu, 21030 Kuala Nerus, Terenganu, Malaysia; Corresponding author at: Faculty of Science and Marine Environment, Universiti Malaysia Terengganu, 21030 Kuala Nerus, Terengganu, Malaysia.Bone tissue regeneration remains a significant challenge in orthopedic medicine due to the limited osteogenic and antimicrobial properties of conventional biomaterials. This study presents an innovative approach to prepare nanocomposite film involving sodium alginate (SA) and polyvinyl alcohol (PVA) blend polymers reinforced with titanium dioxide nanoparticles (TiO2NPs) at varying concentrations (0 wt%, 1 wt%, 5 wt%, 10 wt, and 15 wt%) using solvent casting method. Among these, the PVA + SA@10 wt%TiO2NPs nanocomposite film exhibited exceptional bioactivity and antibacterial properties, positioning it as a promising candidate for bone tissue engineering. Notably, hydroxyapatite (HA) formation was observed within 7 days of immersing the nanocomposite film in simulated body fluid (SBF), effectively mimicking natural bone mineralization. The PVA + SA@10 wt%TiO2NPs nanocomposite demonstrated potent antibacterial activity against S. aureus and E. coli, along with excellent cytocompatibility with MG-63 cells. Advanced characterization techniques, including FTIR, SEM, XRD, and analyses of swelling and porosity, confirmed significant improvements in physicochemical properties, supporting the superior performance of this composite. This scalable, cost-effective material holds substantial potential for advancing regenerative medicine by addressing critical orthopaedic challenges and offering a sustainable solution for bone tissue repair. The novelty of this work lies in the development of the PVA + SA@TiO2NPs composite film, specifically designed to enhance bone regeneration for orthopaedic applications.http://www.sciencedirect.com/science/article/pii/S2211715625000323Bone regenerationPolymersTiO2NanocompositeFilm |
| spellingShingle | Guoying Zhang Xunkai Hou Zhen Geng Mahani Yusoff Nur Adibah Roslan Mohd Hasmizam Razali Enhanced bone regeneration using sodium alginate and polyvinyl alcohol incorporating TiO2 nanoparticles composite film for orthopedic application Results in Chemistry Bone regeneration Polymers TiO2 Nanocomposite Film |
| title | Enhanced bone regeneration using sodium alginate and polyvinyl alcohol incorporating TiO2 nanoparticles composite film for orthopedic application |
| title_full | Enhanced bone regeneration using sodium alginate and polyvinyl alcohol incorporating TiO2 nanoparticles composite film for orthopedic application |
| title_fullStr | Enhanced bone regeneration using sodium alginate and polyvinyl alcohol incorporating TiO2 nanoparticles composite film for orthopedic application |
| title_full_unstemmed | Enhanced bone regeneration using sodium alginate and polyvinyl alcohol incorporating TiO2 nanoparticles composite film for orthopedic application |
| title_short | Enhanced bone regeneration using sodium alginate and polyvinyl alcohol incorporating TiO2 nanoparticles composite film for orthopedic application |
| title_sort | enhanced bone regeneration using sodium alginate and polyvinyl alcohol incorporating tio2 nanoparticles composite film for orthopedic application |
| topic | Bone regeneration Polymers TiO2 Nanocomposite Film |
| url | http://www.sciencedirect.com/science/article/pii/S2211715625000323 |
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