Bisphosphonate Use and Cardiovascular Outcomes According to Kidney Function Status in Post-Menopausal Women: An Emulated Target Trial from the Multi-Ethnic Study of Atherosclerosis

Bisphosphonate Use and Cardiovascular Outcomes According to Kidney Function Status in Post-Menopausal Women: An Emulated Target Trial from the Multi-Ethnic Study of Atherosclerosis

<b>Background/Objectives:</b> Bisphosphonates may influence vascular calcification and atheroma formation via farnesyl pyrophosphate synthase inhibition in the mevalonate pathway regulating bone and lipid metabolism. However, the clinical impact of NCB use on cardiovascular outcomes rema...

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Main Authors: Elena Ghotbi, Nikhil Subhas, Michael P. Bancks, Sammy Elmariah, Jonathan L. Halperin, David A. Bluemke, Bryan R Kestenbaum, R. Graham Barr, Wendy S. Post, Matthew Budoff, João A. C. Lima, Shadpour Demehri
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Diagnostics
Subjects:
bisphosphonates
coronary artery calcium (CAC) score
post-menopausal women
glomerular filtration rate (GFR)
Online Access:https://www.mdpi.com/2075-4418/15/13/1727
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