Role of cardiac CT in the diagnostic evaluation and risk stratification of patients with myocardial infarction and non-obstructive coronary arteries (MINOCA): rationale and design of the MINOCA-GR study
Introduction Myocardial infarction with non-obstructive coronary arteries (MINOCA) occurs in 5%–15% of all patients with acute myocardial infarction. Cardiac MR (CMR) and optical coherence tomography have been used to identify the underlying pathophysiological mechanism in MINOCA. The role of cardia...
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2022-02-01
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| author | Konstantinos Tsioufis Haralambos Karvounis George Giannakoulas Theodoros Karamitsos Ronny R Buechel Konstantinos Kouskouras Ioannis Vogiatzis Konstantinos Toutouzas Nathaniel R Smilowitz Georgios P Rampidis Polydoros Ν Kampaktsis Athanasios Samaras Georgios Benetos Andreas Α Giannopoulos Alexandros Kallifatidis Antonios Samaras Stavros Hadjimiltiades Antonios Ziakas Catherine Gebhard Panagiotis Prassopoulos Harmony Reynolds |
| author_facet | Konstantinos Tsioufis Haralambos Karvounis George Giannakoulas Theodoros Karamitsos Ronny R Buechel Konstantinos Kouskouras Ioannis Vogiatzis Konstantinos Toutouzas Nathaniel R Smilowitz Georgios P Rampidis Polydoros Ν Kampaktsis Athanasios Samaras Georgios Benetos Andreas Α Giannopoulos Alexandros Kallifatidis Antonios Samaras Stavros Hadjimiltiades Antonios Ziakas Catherine Gebhard Panagiotis Prassopoulos Harmony Reynolds |
| author_sort | Konstantinos Tsioufis |
| collection | DOAJ |
| description | Introduction Myocardial infarction with non-obstructive coronary arteries (MINOCA) occurs in 5%–15% of all patients with acute myocardial infarction. Cardiac MR (CMR) and optical coherence tomography have been used to identify the underlying pathophysiological mechanism in MINOCA. The role of cardiac CT angiography (CCTA) in patients with MINOCA, however, has not been well studied so far. CCTA can be used to assess atherosclerotic plaque volume, vulnerable plaque characteristics as well as pericoronary fat tissue attenuation, which has not been yet studied in MINOCA.Methods and analysis MINOCA-GR is a prospective, multicentre, observational cohort study based on a national registry that will use CCTA in combination with CMR and invasive coronary angiography (ICA) to evaluate the extent and characteristics of coronary atherosclerosis and its correlation with pericoronary fat attenuation in patients with MINOCA. A total of 60 consecutive adult patients across 4 participating study sites are expected to be enrolled. Following ICA and CMR, patients will undergo CCTA during index hospitalisation. The primary endpoints are quantification of extent and severity of coronary atherosclerosis, description of high-risk plaque features and attenuation profiling of pericoronary fat tissue around all three major epicardial coronary arteries in relation to CMR. Follow-up CCTA for the evaluation of changes in pericoronary fat attenuation will also be performed. MINOCA-GR aims to be the first study to explore the role of CCTA in combination with CMR and ICA in the underlying pathophysiological mechanisms and assisting in diagnostic evaluation and prognosis of patients with MINOCA.Ethics and dissemination The study protocol has been approved by the institutional review board/independent ethics committee at each site prior to study commencement. All patients will provide written informed consent. Results will be disseminated at national meetings and published in peer-reviewed journals.Trial registration number NCT4186676. |
| format | Article |
| id | doaj-art-7d54c2ec78fd4e0abf393f2f7a7bdb0e |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2022-02-01 |
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| spelling | doaj-art-7d54c2ec78fd4e0abf393f2f7a7bdb0e2025-02-02T10:05:15ZengBMJ Publishing GroupBMJ Open2044-60552022-02-0112210.1136/bmjopen-2021-054698Role of cardiac CT in the diagnostic evaluation and risk stratification of patients with myocardial infarction and non-obstructive coronary arteries (MINOCA): rationale and design of the MINOCA-GR studyKonstantinos Tsioufis0Haralambos Karvounis1George Giannakoulas2Theodoros Karamitsos3Ronny R Buechel4Konstantinos Kouskouras5Ioannis Vogiatzis6Konstantinos Toutouzas7Nathaniel R Smilowitz8Georgios P Rampidis9Polydoros Ν Kampaktsis10Athanasios Samaras11Georgios Benetos12Andreas Α Giannopoulos13Alexandros Kallifatidis14Antonios Samaras15Stavros Hadjimiltiades16Antonios Ziakas17Catherine Gebhard18Panagiotis Prassopoulos19Harmony Reynolds20First Department of Cardiology, Hippokration Hospital, Athens, GreeceFirst Department of Cardiology, University General Hospital of Thessaloniki AHEPA, Thessaloniki, Greecest Department of Cardiology, University General Hospital of Thessaloniki AHEPA, Thessaloniki, GreeceFirst Department of Cardiology, University General Hospital of Thessaloniki AHEPA, Thessaloniki, GreeceDepartment of Nuclear Medicine - Cardiac Imaging Unit, University Hospital Zurich, Zurich, SwitzerlandDepartment of Radiology, University General Hospital of Thessaloniki AHEPA, Thessaloniki, GreeceDepartment of Cardiology, General Hospital of Veroia, Veroia, GreeceFirst Department of Cardiology, Hippokration Hospital, Athens, GreeceDivision of Cardiology, NYU Langone Medical Center, New York, New York, USAFirst Department of Cardiology, University General Hospital of Thessaloniki AHEPA, Thessaloniki, GreeceDivision of Cardiology, NYU Langone Medical Center, New York, New York, USAst Department of Cardiology, University General Hospital of Thessaloniki AHEPA, Thessaloniki, GreeceFirst Department of Cardiology, Hippokration Hospital, Athens, GreeceDepartment of Nuclear Medicine - Cardiac Imaging Unit, University Hospital Zurich, Zurich, SwitzerlandRadiology Department, St Luke`s Hospital, Thessaloniki, GreeceDepartment of Cardiology, General Hospital of Veroia, Veroia, GreeceFirst Department of Cardiology, University General Hospital of Thessaloniki AHEPA, Thessaloniki, Greece1 First Department of Cardiology, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, GreeceDepartment of Nuclear Medicine - Cardiac Imaging Unit, University Hospital Zurich, Zurich, SwitzerlandDepartment of Radiology, University General Hospital of Thessaloniki AHEPA, Thessaloniki, GreeceSarah Ross Soter Center for Women`s Cardiovascular Research, Leon H. Charney Division of Cardiology, Department of Medicine, NYU Grossman School of Medicine, New York, New York, USAIntroduction Myocardial infarction with non-obstructive coronary arteries (MINOCA) occurs in 5%–15% of all patients with acute myocardial infarction. Cardiac MR (CMR) and optical coherence tomography have been used to identify the underlying pathophysiological mechanism in MINOCA. The role of cardiac CT angiography (CCTA) in patients with MINOCA, however, has not been well studied so far. CCTA can be used to assess atherosclerotic plaque volume, vulnerable plaque characteristics as well as pericoronary fat tissue attenuation, which has not been yet studied in MINOCA.Methods and analysis MINOCA-GR is a prospective, multicentre, observational cohort study based on a national registry that will use CCTA in combination with CMR and invasive coronary angiography (ICA) to evaluate the extent and characteristics of coronary atherosclerosis and its correlation with pericoronary fat attenuation in patients with MINOCA. A total of 60 consecutive adult patients across 4 participating study sites are expected to be enrolled. Following ICA and CMR, patients will undergo CCTA during index hospitalisation. The primary endpoints are quantification of extent and severity of coronary atherosclerosis, description of high-risk plaque features and attenuation profiling of pericoronary fat tissue around all three major epicardial coronary arteries in relation to CMR. Follow-up CCTA for the evaluation of changes in pericoronary fat attenuation will also be performed. MINOCA-GR aims to be the first study to explore the role of CCTA in combination with CMR and ICA in the underlying pathophysiological mechanisms and assisting in diagnostic evaluation and prognosis of patients with MINOCA.Ethics and dissemination The study protocol has been approved by the institutional review board/independent ethics committee at each site prior to study commencement. All patients will provide written informed consent. Results will be disseminated at national meetings and published in peer-reviewed journals.Trial registration number NCT4186676.https://bmjopen.bmj.com/content/12/2/e054698.full |
| spellingShingle | Konstantinos Tsioufis Haralambos Karvounis George Giannakoulas Theodoros Karamitsos Ronny R Buechel Konstantinos Kouskouras Ioannis Vogiatzis Konstantinos Toutouzas Nathaniel R Smilowitz Georgios P Rampidis Polydoros Ν Kampaktsis Athanasios Samaras Georgios Benetos Andreas Α Giannopoulos Alexandros Kallifatidis Antonios Samaras Stavros Hadjimiltiades Antonios Ziakas Catherine Gebhard Panagiotis Prassopoulos Harmony Reynolds Role of cardiac CT in the diagnostic evaluation and risk stratification of patients with myocardial infarction and non-obstructive coronary arteries (MINOCA): rationale and design of the MINOCA-GR study BMJ Open |
| title | Role of cardiac CT in the diagnostic evaluation and risk stratification of patients with myocardial infarction and non-obstructive coronary arteries (MINOCA): rationale and design of the MINOCA-GR study |
| title_full | Role of cardiac CT in the diagnostic evaluation and risk stratification of patients with myocardial infarction and non-obstructive coronary arteries (MINOCA): rationale and design of the MINOCA-GR study |
| title_fullStr | Role of cardiac CT in the diagnostic evaluation and risk stratification of patients with myocardial infarction and non-obstructive coronary arteries (MINOCA): rationale and design of the MINOCA-GR study |
| title_full_unstemmed | Role of cardiac CT in the diagnostic evaluation and risk stratification of patients with myocardial infarction and non-obstructive coronary arteries (MINOCA): rationale and design of the MINOCA-GR study |
| title_short | Role of cardiac CT in the diagnostic evaluation and risk stratification of patients with myocardial infarction and non-obstructive coronary arteries (MINOCA): rationale and design of the MINOCA-GR study |
| title_sort | role of cardiac ct in the diagnostic evaluation and risk stratification of patients with myocardial infarction and non obstructive coronary arteries minoca rationale and design of the minoca gr study |
| url | https://bmjopen.bmj.com/content/12/2/e054698.full |
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