Schistosoma Tegument Proteins in Vaccine and Diagnosis Development: An Update
The development of a vaccine against schistosomiasis and also the availability of a more sensitive diagnosis test are important tools to help chemotherapy in controlling disease transmission. Bioinformatics tools, together with the access to parasite genome, published recently, should help generate...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Journal of Parasitology Research |
| Online Access: | http://dx.doi.org/10.1155/2012/541268 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832558733945733120 |
|---|---|
| author | Cristina Toscano Fonseca Gardênia Braz Figueiredo Carvalho Clarice Carvalho Alves Tatiane Teixeira de Melo |
| author_facet | Cristina Toscano Fonseca Gardênia Braz Figueiredo Carvalho Clarice Carvalho Alves Tatiane Teixeira de Melo |
| author_sort | Cristina Toscano Fonseca |
| collection | DOAJ |
| description | The development of a vaccine against schistosomiasis and also the availability of a more sensitive diagnosis test are important tools to help chemotherapy in controlling disease transmission. Bioinformatics tools, together with the access to parasite genome, published recently, should help generate new knowledge on parasite biology and search for new vaccines or therapeutic targets and antigens to be used in the disease diagnosis. Parasite surface proteins, especially those expressed in schistosomula tegument, represent interesting targets to be used in vaccine formulations and in the diagnosis of early infections, since the tegument represents the interface between host and parasite and its molecules are responsible for essential functions to parasite survival. In this paper we will present the advances in the development of vaccines and diagnosis tests achieved with the use of the information from schistosome genome focused on parasite tegument as a source for antigens. |
| format | Article |
| id | doaj-art-7d3cd7933b80455ba15ca4fa8eb12984 |
| institution | Kabale University |
| issn | 2090-0023 2090-0031 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Parasitology Research |
| spelling | doaj-art-7d3cd7933b80455ba15ca4fa8eb129842025-02-03T01:31:38ZengWileyJournal of Parasitology Research2090-00232090-00312012-01-01201210.1155/2012/541268541268Schistosoma Tegument Proteins in Vaccine and Diagnosis Development: An UpdateCristina Toscano Fonseca0Gardênia Braz Figueiredo Carvalho1Clarice Carvalho Alves2Tatiane Teixeira de Melo3Laboratório de Esquistossomose, Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Avenida Augusto de Lima 1715, Belo Horizonte,MG 30190-002, BrazilLaboratório de Esquistossomose, Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Avenida Augusto de Lima 1715, Belo Horizonte,MG 30190-002, BrazilLaboratório de Esquistossomose, Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Avenida Augusto de Lima 1715, Belo Horizonte,MG 30190-002, BrazilLaboratório de Esquistossomose, Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Avenida Augusto de Lima 1715, Belo Horizonte,MG 30190-002, BrazilThe development of a vaccine against schistosomiasis and also the availability of a more sensitive diagnosis test are important tools to help chemotherapy in controlling disease transmission. Bioinformatics tools, together with the access to parasite genome, published recently, should help generate new knowledge on parasite biology and search for new vaccines or therapeutic targets and antigens to be used in the disease diagnosis. Parasite surface proteins, especially those expressed in schistosomula tegument, represent interesting targets to be used in vaccine formulations and in the diagnosis of early infections, since the tegument represents the interface between host and parasite and its molecules are responsible for essential functions to parasite survival. In this paper we will present the advances in the development of vaccines and diagnosis tests achieved with the use of the information from schistosome genome focused on parasite tegument as a source for antigens.http://dx.doi.org/10.1155/2012/541268 |
| spellingShingle | Cristina Toscano Fonseca Gardênia Braz Figueiredo Carvalho Clarice Carvalho Alves Tatiane Teixeira de Melo Schistosoma Tegument Proteins in Vaccine and Diagnosis Development: An Update Journal of Parasitology Research |
| title | Schistosoma Tegument Proteins in Vaccine and Diagnosis Development: An Update |
| title_full | Schistosoma Tegument Proteins in Vaccine and Diagnosis Development: An Update |
| title_fullStr | Schistosoma Tegument Proteins in Vaccine and Diagnosis Development: An Update |
| title_full_unstemmed | Schistosoma Tegument Proteins in Vaccine and Diagnosis Development: An Update |
| title_short | Schistosoma Tegument Proteins in Vaccine and Diagnosis Development: An Update |
| title_sort | schistosoma tegument proteins in vaccine and diagnosis development an update |
| url | http://dx.doi.org/10.1155/2012/541268 |
| work_keys_str_mv | AT cristinatoscanofonseca schistosomategumentproteinsinvaccineanddiagnosisdevelopmentanupdate AT gardeniabrazfigueiredocarvalho schistosomategumentproteinsinvaccineanddiagnosisdevelopmentanupdate AT claricecarvalhoalves schistosomategumentproteinsinvaccineanddiagnosisdevelopmentanupdate AT tatianeteixeirademelo schistosomategumentproteinsinvaccineanddiagnosisdevelopmentanupdate |