IFI44L as a Forward Regulator Enhancing Host Antituberculosis Responses
Interferon-induced protein 44-like (IFI44L) gene is a type I interferon-stimulated gene (ISG) that plays a critical role in antiviral activity and constitutes a promising diagnostic marker. However, its precise role and function in tuberculosis have not been unveiled. This study showed that IFI44L a...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2021/5599408 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832556898441756672 |
|---|---|
| author | Haiqin Jiang Lemuel Tsang Hongsheng Wang Changhong Liu |
| author_facet | Haiqin Jiang Lemuel Tsang Hongsheng Wang Changhong Liu |
| author_sort | Haiqin Jiang |
| collection | DOAJ |
| description | Interferon-induced protein 44-like (IFI44L) gene is a type I interferon-stimulated gene (ISG) that plays a critical role in antiviral activity and constitutes a promising diagnostic marker. However, its precise role and function in tuberculosis have not been unveiled. This study showed that IFI44L acts as an antimicrobial target and positive modulator in human macrophages. Knockdown of IFI44L led to increased Mycobacterium tuberculosis intracellular survival. Moreover, IFI44L was significantly upregulated, and it restricted the intracellular survival of M. tuberculosis H37Rv strains at 72 h after rifampicin treatment. Individuals with cutaneous tuberculosis (CTB) were found to have significantly higher IFI44L expression after 6 months of rifampicin therapy than after only 1 month. These results demonstrated that IFI44L induced positive regulation and clearance of M. tuberculosis from human macrophages. This antimicrobial activity of IFI44L makes it a possible target for therapeutic applications against M. tuberculosis. |
| format | Article |
| id | doaj-art-7d34fb51e07e48a8a95940d4ec7406c3 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-7d34fb51e07e48a8a95940d4ec7406c32025-02-03T05:44:08ZengWileyJournal of Immunology Research2314-88612314-71562021-01-01202110.1155/2021/55994085599408IFI44L as a Forward Regulator Enhancing Host Antituberculosis ResponsesHaiqin Jiang0Lemuel Tsang1Hongsheng Wang2Changhong Liu3State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, ChinaCollege of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USAInstitute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, ChinaState Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, ChinaInterferon-induced protein 44-like (IFI44L) gene is a type I interferon-stimulated gene (ISG) that plays a critical role in antiviral activity and constitutes a promising diagnostic marker. However, its precise role and function in tuberculosis have not been unveiled. This study showed that IFI44L acts as an antimicrobial target and positive modulator in human macrophages. Knockdown of IFI44L led to increased Mycobacterium tuberculosis intracellular survival. Moreover, IFI44L was significantly upregulated, and it restricted the intracellular survival of M. tuberculosis H37Rv strains at 72 h after rifampicin treatment. Individuals with cutaneous tuberculosis (CTB) were found to have significantly higher IFI44L expression after 6 months of rifampicin therapy than after only 1 month. These results demonstrated that IFI44L induced positive regulation and clearance of M. tuberculosis from human macrophages. This antimicrobial activity of IFI44L makes it a possible target for therapeutic applications against M. tuberculosis.http://dx.doi.org/10.1155/2021/5599408 |
| spellingShingle | Haiqin Jiang Lemuel Tsang Hongsheng Wang Changhong Liu IFI44L as a Forward Regulator Enhancing Host Antituberculosis Responses Journal of Immunology Research |
| title | IFI44L as a Forward Regulator Enhancing Host Antituberculosis Responses |
| title_full | IFI44L as a Forward Regulator Enhancing Host Antituberculosis Responses |
| title_fullStr | IFI44L as a Forward Regulator Enhancing Host Antituberculosis Responses |
| title_full_unstemmed | IFI44L as a Forward Regulator Enhancing Host Antituberculosis Responses |
| title_short | IFI44L as a Forward Regulator Enhancing Host Antituberculosis Responses |
| title_sort | ifi44l as a forward regulator enhancing host antituberculosis responses |
| url | http://dx.doi.org/10.1155/2021/5599408 |
| work_keys_str_mv | AT haiqinjiang ifi44lasaforwardregulatorenhancinghostantituberculosisresponses AT lemueltsang ifi44lasaforwardregulatorenhancinghostantituberculosisresponses AT hongshengwang ifi44lasaforwardregulatorenhancinghostantituberculosisresponses AT changhongliu ifi44lasaforwardregulatorenhancinghostantituberculosisresponses |