Therapeutic Options in the Treatment and Prevention of Nonsteroidal Anti-Inflammatory Drug-Induced Ulceration
This article reviews the current status of H2 receptor antagonists, omeprazole, sucralfate and misoprostol as therapeutic options for the prophylaxis and treatment of nonsteroidal anti-inflammatory drug (NSAID)-induced gastrointestinal ulceration. The efficacy of the Hz receptor antagonists appears...
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1990-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1990/826248 |
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| _version_ | 1832563097433276416 |
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| author | Malcolm C Champion |
| author_facet | Malcolm C Champion |
| author_sort | Malcolm C Champion |
| collection | DOAJ |
| description | This article reviews the current status of H2 receptor antagonists,
omeprazole, sucralfate and misoprostol as therapeutic options for the prophylaxis
and treatment of nonsteroidal anti-inflammatory drug (NSAID)-induced
gastrointestinal ulceration. The efficacy of the Hz receptor antagonists appears
to be restricted to prophylaxis and treatment of NSAID-induced duodenal ulcer
disease. Omeprazole may have a place in the future treatment of NSAID-induced
gastric ulcers. However, more studies are necessary to examine this drug's efficacy
in both the prophylaxis and treatment of NSAID-induced ulceration. Sucralface
improves symptoms, but does not appear to have any effect on improving gastric
mucosal damage when compared to placebo. It may, however, be useful in the
treatment of NSAID-induced duodenal ulcers. Misoprostol is effective in both
the prophylaxis and treatment of NSAID-induced gastric ulcers; however, its
exact role in the prophylaxis and treatment of NSAlD-induced duodenal ulcers
remains to be defined. |
| format | Article |
| id | doaj-art-7d31e7bc2b6d410c874e2e3effbfc0ba |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 1990-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-7d31e7bc2b6d410c874e2e3effbfc0ba2025-02-03T01:20:59ZengWileyCanadian Journal of Gastroenterology0835-79001990-01-014311311910.1155/1990/826248Therapeutic Options in the Treatment and Prevention of Nonsteroidal Anti-Inflammatory Drug-Induced UlcerationMalcolm C ChampionThis article reviews the current status of H2 receptor antagonists, omeprazole, sucralfate and misoprostol as therapeutic options for the prophylaxis and treatment of nonsteroidal anti-inflammatory drug (NSAID)-induced gastrointestinal ulceration. The efficacy of the Hz receptor antagonists appears to be restricted to prophylaxis and treatment of NSAID-induced duodenal ulcer disease. Omeprazole may have a place in the future treatment of NSAID-induced gastric ulcers. However, more studies are necessary to examine this drug's efficacy in both the prophylaxis and treatment of NSAID-induced ulceration. Sucralface improves symptoms, but does not appear to have any effect on improving gastric mucosal damage when compared to placebo. It may, however, be useful in the treatment of NSAID-induced duodenal ulcers. Misoprostol is effective in both the prophylaxis and treatment of NSAID-induced gastric ulcers; however, its exact role in the prophylaxis and treatment of NSAlD-induced duodenal ulcers remains to be defined.http://dx.doi.org/10.1155/1990/826248 |
| spellingShingle | Malcolm C Champion Therapeutic Options in the Treatment and Prevention of Nonsteroidal Anti-Inflammatory Drug-Induced Ulceration Canadian Journal of Gastroenterology |
| title | Therapeutic Options in the Treatment and Prevention of Nonsteroidal Anti-Inflammatory Drug-Induced Ulceration |
| title_full | Therapeutic Options in the Treatment and Prevention of Nonsteroidal Anti-Inflammatory Drug-Induced Ulceration |
| title_fullStr | Therapeutic Options in the Treatment and Prevention of Nonsteroidal Anti-Inflammatory Drug-Induced Ulceration |
| title_full_unstemmed | Therapeutic Options in the Treatment and Prevention of Nonsteroidal Anti-Inflammatory Drug-Induced Ulceration |
| title_short | Therapeutic Options in the Treatment and Prevention of Nonsteroidal Anti-Inflammatory Drug-Induced Ulceration |
| title_sort | therapeutic options in the treatment and prevention of nonsteroidal anti inflammatory drug induced ulceration |
| url | http://dx.doi.org/10.1155/1990/826248 |
| work_keys_str_mv | AT malcolmcchampion therapeuticoptionsinthetreatmentandpreventionofnonsteroidalantiinflammatorydruginducedulceration |