ROLE OF HETEROZYGOUS TUMOR SUPPRESSORS IN THE LIFE LONGEVITY OF DROSOPHILA MELANOGASTER
Role of tumor-suppressor genes in the life longevity has not been studied in detail. The purpose of the current work is to study the influence of heterozygous tumor suppressors on the life span of drosophila. We show that heterozygotes for l(3)hem, hyd, gd, ex or ft, both females and males, have a s...
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| Format: | Article |
| Language: | English |
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Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders
2015-01-01
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| Series: | Вавиловский журнал генетики и селекции |
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| Online Access: | https://vavilov.elpub.ru/jour/article/view/161 |
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| _version_ | 1832575307996987392 |
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| author | S. A. Kopyl L. V. Omelyanchuk M. V. Shaposhnikov A. A. Moskalev |
| author_facet | S. A. Kopyl L. V. Omelyanchuk M. V. Shaposhnikov A. A. Moskalev |
| author_sort | S. A. Kopyl |
| collection | DOAJ |
| description | Role of tumor-suppressor genes in the life longevity has not been studied in detail. The purpose of the current work is to study the influence of heterozygous tumor suppressors on the life span of drosophila. We show that heterozygotes for l(3)hem, hyd, gd, ex or ft, both females and males, have a shorter life. The analysis of Gompertz curve parameters indicates that the l(3)hem, hyd or gd mutations increase age-related parameter (α) in males, while gd mutation increases the death background parameter (R) and the ex agerelated parameter in females. The effects of the mutations on the life span are probably associated with hedgehog (hyd), Notch (gd) и Hippo (ex и ft) signal transduction pathways. |
| format | Article |
| id | doaj-art-7d2880becdd8416aaa9541f83a0b435a |
| institution | Kabale University |
| issn | 2500-3259 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders |
| record_format | Article |
| series | Вавиловский журнал генетики и селекции |
| spelling | doaj-art-7d2880becdd8416aaa9541f83a0b435a2025-02-01T09:57:59ZengSiberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and BreedersВавиловский журнал генетики и селекции2500-32592015-01-01173390398145ROLE OF HETEROZYGOUS TUMOR SUPPRESSORS IN THE LIFE LONGEVITY OF DROSOPHILA MELANOGASTERS. A. Kopyl0L. V. Omelyanchuk1M. V. Shaposhnikov2A. A. Moskalev3Institute of Molecular and Cellular Biology SB RAS, Novosibirsk, RussiaInstitute of Molecular and Cellular Biology SB RAS, Novosibirsk, RussiaInstitute of Biоlogy, Komi Center of UB RAS, Syktivkar, Russia Syktivkar State University, RussiaInstitute of Biоlogy, Komi Center of UB RAS, Syktivkar, Russia Syktivkar State University, Russia Moscow Institute of Physics and Technology, Moscow, RussiaRole of tumor-suppressor genes in the life longevity has not been studied in detail. The purpose of the current work is to study the influence of heterozygous tumor suppressors on the life span of drosophila. We show that heterozygotes for l(3)hem, hyd, gd, ex or ft, both females and males, have a shorter life. The analysis of Gompertz curve parameters indicates that the l(3)hem, hyd or gd mutations increase age-related parameter (α) in males, while gd mutation increases the death background parameter (R) and the ex agerelated parameter in females. The effects of the mutations on the life span are probably associated with hedgehog (hyd), Notch (gd) и Hippo (ex и ft) signal transduction pathways.https://vavilov.elpub.ru/jour/article/view/161longevitytumor suppressorsgompertz curvedrosophila melanogaster |
| spellingShingle | S. A. Kopyl L. V. Omelyanchuk M. V. Shaposhnikov A. A. Moskalev ROLE OF HETEROZYGOUS TUMOR SUPPRESSORS IN THE LIFE LONGEVITY OF DROSOPHILA MELANOGASTER Вавиловский журнал генетики и селекции longevity tumor suppressors gompertz curve drosophila melanogaster |
| title | ROLE OF HETEROZYGOUS TUMOR SUPPRESSORS IN THE LIFE LONGEVITY OF DROSOPHILA MELANOGASTER |
| title_full | ROLE OF HETEROZYGOUS TUMOR SUPPRESSORS IN THE LIFE LONGEVITY OF DROSOPHILA MELANOGASTER |
| title_fullStr | ROLE OF HETEROZYGOUS TUMOR SUPPRESSORS IN THE LIFE LONGEVITY OF DROSOPHILA MELANOGASTER |
| title_full_unstemmed | ROLE OF HETEROZYGOUS TUMOR SUPPRESSORS IN THE LIFE LONGEVITY OF DROSOPHILA MELANOGASTER |
| title_short | ROLE OF HETEROZYGOUS TUMOR SUPPRESSORS IN THE LIFE LONGEVITY OF DROSOPHILA MELANOGASTER |
| title_sort | role of heterozygous tumor suppressors in the life longevity of drosophila melanogaster |
| topic | longevity tumor suppressors gompertz curve drosophila melanogaster |
| url | https://vavilov.elpub.ru/jour/article/view/161 |
| work_keys_str_mv | AT sakopyl roleofheterozygoustumorsuppressorsinthelifelongevityofdrosophilamelanogaster AT lvomelyanchuk roleofheterozygoustumorsuppressorsinthelifelongevityofdrosophilamelanogaster AT mvshaposhnikov roleofheterozygoustumorsuppressorsinthelifelongevityofdrosophilamelanogaster AT aamoskalev roleofheterozygoustumorsuppressorsinthelifelongevityofdrosophilamelanogaster |