Diagnosis of Granulomatosis With Polyangiitis in a 39‐Year‐Old Woman With a Recent History of Traveling to Malaria‐Endemic Region: A Case Report
ABSTRACT Granulomatosis with Polyangiitis (GPA) is a rare vasculitis that can complicate the diagnostic process, especially in patients with complex medical histories. This case report details a 39‐year‐old woman with situs inversus totalis, Kartagener syndrome, and hypothyroidism, who presented to...
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Wiley
2025-03-01
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| Series: | Clinical Case Reports |
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| Online Access: | https://doi.org/10.1002/ccr3.70327 |
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| author | Hanie Forouzandeh Ahmadreza Rajabi Abbas Ali Torfeh Esfahani Farzin Khorvash Mansoor Karimifar |
| author_facet | Hanie Forouzandeh Ahmadreza Rajabi Abbas Ali Torfeh Esfahani Farzin Khorvash Mansoor Karimifar |
| author_sort | Hanie Forouzandeh |
| collection | DOAJ |
| description | ABSTRACT Granulomatosis with Polyangiitis (GPA) is a rare vasculitis that can complicate the diagnostic process, especially in patients with complex medical histories. This case report details a 39‐year‐old woman with situs inversus totalis, Kartagener syndrome, and hypothyroidism, who presented to the emergency department with intermittent petechiae, purpura in the lower limbs, and fever following a trip to a malaria‐endemic region. Initial investigations suggested an infectious etiology, but extensive testing for malaria and other infections returned negative results. A transition to autoimmune disease assessment was prompted by the positive results of rheumatologic tests. Pulse doses of Methylprednisolone Sodium Succinate and Rituximab were initiated, and the treatment was continued with Prednisolone, Azathioprine, and Calcium D tablets. The patient's signs and symptoms have improved after this treatment. This case underscores the necessity of considering a comprehensive differential diagnosis and advocating for a meticulous and systematic approach in complex clinical presentations. |
| format | Article |
| id | doaj-art-7cee38ea7d0d4e2e9c0658f9bc903cc2 |
| institution | DOAJ |
| issn | 2050-0904 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical Case Reports |
| spelling | doaj-art-7cee38ea7d0d4e2e9c0658f9bc903cc22025-08-20T02:50:55ZengWileyClinical Case Reports2050-09042025-03-01133n/an/a10.1002/ccr3.70327Diagnosis of Granulomatosis With Polyangiitis in a 39‐Year‐Old Woman With a Recent History of Traveling to Malaria‐Endemic Region: A Case ReportHanie Forouzandeh0Ahmadreza Rajabi1Abbas Ali Torfeh Esfahani2Farzin Khorvash3Mansoor Karimifar4School of Medicine Isfahan University of Medical Sciences Isfahan IranSchool of Medicine Isfahan University of Medical Sciences Isfahan IranDepartment of Infectious Diseases and Tropical Medicine, School of Medicine Isfahan University of Medical Sciences Isfahan IranDepartment of Infectious Diseases and Tropical Medicine, School of Medicine Isfahan University of Medical Sciences Isfahan IranDepartment of Rheumatology Alzahra Hospital, Isfahan University of Medical Sciences Isfahan IranABSTRACT Granulomatosis with Polyangiitis (GPA) is a rare vasculitis that can complicate the diagnostic process, especially in patients with complex medical histories. This case report details a 39‐year‐old woman with situs inversus totalis, Kartagener syndrome, and hypothyroidism, who presented to the emergency department with intermittent petechiae, purpura in the lower limbs, and fever following a trip to a malaria‐endemic region. Initial investigations suggested an infectious etiology, but extensive testing for malaria and other infections returned negative results. A transition to autoimmune disease assessment was prompted by the positive results of rheumatologic tests. Pulse doses of Methylprednisolone Sodium Succinate and Rituximab were initiated, and the treatment was continued with Prednisolone, Azathioprine, and Calcium D tablets. The patient's signs and symptoms have improved after this treatment. This case underscores the necessity of considering a comprehensive differential diagnosis and advocating for a meticulous and systematic approach in complex clinical presentations.https://doi.org/10.1002/ccr3.70327autoimmune diseasegranulomatosis with polyangiitisinfectious diseaseWegener's granulomatosis |
| spellingShingle | Hanie Forouzandeh Ahmadreza Rajabi Abbas Ali Torfeh Esfahani Farzin Khorvash Mansoor Karimifar Diagnosis of Granulomatosis With Polyangiitis in a 39‐Year‐Old Woman With a Recent History of Traveling to Malaria‐Endemic Region: A Case Report Clinical Case Reports autoimmune disease granulomatosis with polyangiitis infectious disease Wegener's granulomatosis |
| title | Diagnosis of Granulomatosis With Polyangiitis in a 39‐Year‐Old Woman With a Recent History of Traveling to Malaria‐Endemic Region: A Case Report |
| title_full | Diagnosis of Granulomatosis With Polyangiitis in a 39‐Year‐Old Woman With a Recent History of Traveling to Malaria‐Endemic Region: A Case Report |
| title_fullStr | Diagnosis of Granulomatosis With Polyangiitis in a 39‐Year‐Old Woman With a Recent History of Traveling to Malaria‐Endemic Region: A Case Report |
| title_full_unstemmed | Diagnosis of Granulomatosis With Polyangiitis in a 39‐Year‐Old Woman With a Recent History of Traveling to Malaria‐Endemic Region: A Case Report |
| title_short | Diagnosis of Granulomatosis With Polyangiitis in a 39‐Year‐Old Woman With a Recent History of Traveling to Malaria‐Endemic Region: A Case Report |
| title_sort | diagnosis of granulomatosis with polyangiitis in a 39 year old woman with a recent history of traveling to malaria endemic region a case report |
| topic | autoimmune disease granulomatosis with polyangiitis infectious disease Wegener's granulomatosis |
| url | https://doi.org/10.1002/ccr3.70327 |
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