Anti-Inflammatory Property of the Ethanol Extract of the Root and Rhizome of Pogostemon cablin (Blanco) Benth
The aim of this study was to investigate the anti-inflammatory property of the ethanol extract of the root and rhizome of Pogostemon cablin (ERP). The anti-inflammatory effect was evaluated using four animal models including xylene-induced mouse ear edema, acetic acid-induced mouse vascular permeabi...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/434151 |
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| author | Chu-Wen Li Xiao-Li Wu Xiao-Ning Zhao Zu-Qing Su Hai-Ming Chen Xiu-Fen Wang Xiao-Jun Zhang Hui-Fang Zeng Jian-Nan Chen Yu-Cui Li Zi-Ren Su |
| author_facet | Chu-Wen Li Xiao-Li Wu Xiao-Ning Zhao Zu-Qing Su Hai-Ming Chen Xiu-Fen Wang Xiao-Jun Zhang Hui-Fang Zeng Jian-Nan Chen Yu-Cui Li Zi-Ren Su |
| author_sort | Chu-Wen Li |
| collection | DOAJ |
| description | The aim of this study was to investigate the anti-inflammatory property of the ethanol extract of the root and rhizome of Pogostemon cablin (ERP). The anti-inflammatory effect was evaluated using four animal models including xylene-induced mouse ear edema, acetic acid-induced mouse vascular permeability, carrageenan-induced mouse pleurisy, and carrageenan-induced mouse hind paw edema. Results indicated that oral administration of ERP (120, 240, and 480 mg/kg) significantly attenuated xylene-induced ear edema, decreased acetic acid-induced capillary permeability, inhibited carrageenan-induced neutrophils recruitment, and reduced carrageenan-induced paw edema, in a dose-dependent manner. Histopathologically, ERP (480 mg/kg) abated inflammatory response of the edema paw. Preliminary mechanism studies demonstrated that ERP decreased the level of MPO and MDA, increased the activities of anti-oxidant enzymes (SOD, GPx, and GRd), attenuated the productions of TNF-α, IL-1β, IL-6, PGE2 and NO, and suppressed the activities of COX-2 and iNOS. This work demonstrates that ERP has considerable anti-inflammatory potential, which provided experimental evidences for the traditional application of the root and rhizome of Pogostemon cablin in inflammatory diseases. |
| format | Article |
| id | doaj-art-7cd253501e184cf3a85994d13cdccf9e |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-7cd253501e184cf3a85994d13cdccf9e2025-02-03T05:58:24ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/434151434151Anti-Inflammatory Property of the Ethanol Extract of the Root and Rhizome of Pogostemon cablin (Blanco) BenthChu-Wen Li0Xiao-Li Wu1Xiao-Ning Zhao2Zu-Qing Su3Hai-Ming Chen4Xiu-Fen Wang5Xiao-Jun Zhang6Hui-Fang Zeng7Jian-Nan Chen8Yu-Cui Li9Zi-Ren Su10School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, ChinaSchool of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, ChinaThe First Hospital Affiliated Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong 510405, ChinaSchool of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, ChinaSchool of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, ChinaSchool of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, ChinaSchool of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, ChinaThe First Hospital Affiliated Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong 510405, ChinaSchool of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, ChinaSchool of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, ChinaSchool of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, ChinaThe aim of this study was to investigate the anti-inflammatory property of the ethanol extract of the root and rhizome of Pogostemon cablin (ERP). The anti-inflammatory effect was evaluated using four animal models including xylene-induced mouse ear edema, acetic acid-induced mouse vascular permeability, carrageenan-induced mouse pleurisy, and carrageenan-induced mouse hind paw edema. Results indicated that oral administration of ERP (120, 240, and 480 mg/kg) significantly attenuated xylene-induced ear edema, decreased acetic acid-induced capillary permeability, inhibited carrageenan-induced neutrophils recruitment, and reduced carrageenan-induced paw edema, in a dose-dependent manner. Histopathologically, ERP (480 mg/kg) abated inflammatory response of the edema paw. Preliminary mechanism studies demonstrated that ERP decreased the level of MPO and MDA, increased the activities of anti-oxidant enzymes (SOD, GPx, and GRd), attenuated the productions of TNF-α, IL-1β, IL-6, PGE2 and NO, and suppressed the activities of COX-2 and iNOS. This work demonstrates that ERP has considerable anti-inflammatory potential, which provided experimental evidences for the traditional application of the root and rhizome of Pogostemon cablin in inflammatory diseases.http://dx.doi.org/10.1155/2013/434151 |
| spellingShingle | Chu-Wen Li Xiao-Li Wu Xiao-Ning Zhao Zu-Qing Su Hai-Ming Chen Xiu-Fen Wang Xiao-Jun Zhang Hui-Fang Zeng Jian-Nan Chen Yu-Cui Li Zi-Ren Su Anti-Inflammatory Property of the Ethanol Extract of the Root and Rhizome of Pogostemon cablin (Blanco) Benth The Scientific World Journal |
| title | Anti-Inflammatory Property of the Ethanol Extract of the Root and Rhizome of Pogostemon cablin (Blanco) Benth |
| title_full | Anti-Inflammatory Property of the Ethanol Extract of the Root and Rhizome of Pogostemon cablin (Blanco) Benth |
| title_fullStr | Anti-Inflammatory Property of the Ethanol Extract of the Root and Rhizome of Pogostemon cablin (Blanco) Benth |
| title_full_unstemmed | Anti-Inflammatory Property of the Ethanol Extract of the Root and Rhizome of Pogostemon cablin (Blanco) Benth |
| title_short | Anti-Inflammatory Property of the Ethanol Extract of the Root and Rhizome of Pogostemon cablin (Blanco) Benth |
| title_sort | anti inflammatory property of the ethanol extract of the root and rhizome of pogostemon cablin blanco benth |
| url | http://dx.doi.org/10.1155/2013/434151 |
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