Anti-Parkinson Activity of Petroleum Ether Extract of Ficus religiosa (L.) Leaves
In the present study, we evaluated anti-Parkinson’s activity of petroleum ether extract of Ficus religiosa (PEFRE) leaves in haloperidol and 6 hydroxydopamine (6-OHDA) induced experimental animal models. In this study, effects of Ficus religiosa (100, 200, and 400 mg/kg, p.o.) were studied using in...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Advances in Pharmacological Sciences |
| Online Access: | http://dx.doi.org/10.1155/2016/9436106 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832564546353496064 |
|---|---|
| author | Jitendra O. Bhangale Sanjeev R. Acharya |
| author_facet | Jitendra O. Bhangale Sanjeev R. Acharya |
| author_sort | Jitendra O. Bhangale |
| collection | DOAJ |
| description | In the present study, we evaluated anti-Parkinson’s activity of petroleum ether extract of Ficus religiosa (PEFRE) leaves in haloperidol and 6 hydroxydopamine (6-OHDA) induced experimental animal models. In this study, effects of Ficus religiosa (100, 200, and 400 mg/kg, p.o.) were studied using in vivo behavioral parameters like catalepsy, muscle rigidity, and locomotor activity and its effects on neurochemical parameters (MDA, CAT, SOD, and GSH) in rats. The experiment was designed by giving haloperidol to induce catalepsy and 6-OHDA to induce Parkinson’s disease-like symptoms. The increased cataleptic scores (induced by haloperidol) were significantly (p<0.001) found to be reduced, with the PEFRE at a dose of 200 and 400 mg/kg (p.o.). 6-OHDA significantly induced motor dysfunction (muscle rigidity and hypolocomotion). 6-OHDA administration showed significant increase in lipid peroxidation level and depleted superoxide dismutase, catalase, and reduced glutathione level. Daily administration of PEFRE (400 mg/kg) significantly improved motor performance and also significantly attenuated oxidative damage. Thus, the study proved that Ficus religiosa treatment significantly attenuated the motor defects and also protected the brain from oxidative stress. |
| format | Article |
| id | doaj-art-7ccd453e9e3a4ee0a5f09ce953f323d4 |
| institution | Kabale University |
| issn | 1687-6334 1687-6342 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Pharmacological Sciences |
| spelling | doaj-art-7ccd453e9e3a4ee0a5f09ce953f323d42025-02-03T01:10:45ZengWileyAdvances in Pharmacological Sciences1687-63341687-63422016-01-01201610.1155/2016/94361069436106Anti-Parkinson Activity of Petroleum Ether Extract of Ficus religiosa (L.) LeavesJitendra O. Bhangale0Sanjeev R. Acharya1Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat 382 481, IndiaInstitute of Pharmacy, Nirma University, Ahmedabad, Gujarat 382 481, IndiaIn the present study, we evaluated anti-Parkinson’s activity of petroleum ether extract of Ficus religiosa (PEFRE) leaves in haloperidol and 6 hydroxydopamine (6-OHDA) induced experimental animal models. In this study, effects of Ficus religiosa (100, 200, and 400 mg/kg, p.o.) were studied using in vivo behavioral parameters like catalepsy, muscle rigidity, and locomotor activity and its effects on neurochemical parameters (MDA, CAT, SOD, and GSH) in rats. The experiment was designed by giving haloperidol to induce catalepsy and 6-OHDA to induce Parkinson’s disease-like symptoms. The increased cataleptic scores (induced by haloperidol) were significantly (p<0.001) found to be reduced, with the PEFRE at a dose of 200 and 400 mg/kg (p.o.). 6-OHDA significantly induced motor dysfunction (muscle rigidity and hypolocomotion). 6-OHDA administration showed significant increase in lipid peroxidation level and depleted superoxide dismutase, catalase, and reduced glutathione level. Daily administration of PEFRE (400 mg/kg) significantly improved motor performance and also significantly attenuated oxidative damage. Thus, the study proved that Ficus religiosa treatment significantly attenuated the motor defects and also protected the brain from oxidative stress.http://dx.doi.org/10.1155/2016/9436106 |
| spellingShingle | Jitendra O. Bhangale Sanjeev R. Acharya Anti-Parkinson Activity of Petroleum Ether Extract of Ficus religiosa (L.) Leaves Advances in Pharmacological Sciences |
| title | Anti-Parkinson Activity of Petroleum Ether Extract of Ficus religiosa (L.) Leaves |
| title_full | Anti-Parkinson Activity of Petroleum Ether Extract of Ficus religiosa (L.) Leaves |
| title_fullStr | Anti-Parkinson Activity of Petroleum Ether Extract of Ficus religiosa (L.) Leaves |
| title_full_unstemmed | Anti-Parkinson Activity of Petroleum Ether Extract of Ficus religiosa (L.) Leaves |
| title_short | Anti-Parkinson Activity of Petroleum Ether Extract of Ficus religiosa (L.) Leaves |
| title_sort | anti parkinson activity of petroleum ether extract of ficus religiosa l leaves |
| url | http://dx.doi.org/10.1155/2016/9436106 |
| work_keys_str_mv | AT jitendraobhangale antiparkinsonactivityofpetroleumetherextractofficusreligiosalleaves AT sanjeevracharya antiparkinsonactivityofpetroleumetherextractofficusreligiosalleaves |