An ultrasound-driven PLGA/Zn-KNN hybrid piezoelectric scaffold with direct and immunoregulatory antibacterial activity for bone infection
Antibacterial piezoelectric materials have broad application prospects in the medical field because of their broad-spectrum antibacterial properties and no bacterial drug resistance. At present, one of the main problems in the application of piezoelectric materials is the low electrocatalytic effici...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-05-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X2500026X |
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| author | Yuhao Zheng Shu Wang Wenhe Jin Zhuoxuan Li Guoju Yang Xiaoxu Li Ning Li Yue Wang Fan Sheng Zhiming Song |
| author_facet | Yuhao Zheng Shu Wang Wenhe Jin Zhuoxuan Li Guoju Yang Xiaoxu Li Ning Li Yue Wang Fan Sheng Zhiming Song |
| author_sort | Yuhao Zheng |
| collection | DOAJ |
| description | Antibacterial piezoelectric materials have broad application prospects in the medical field because of their broad-spectrum antibacterial properties and no bacterial drug resistance. At present, one of the main problems in the application of piezoelectric materials is the low electrocatalytic efficiency, which limits its application in antibacterial field. In this study, a piezoelectric antibacterial (PLGA/Zn-KNN) scaffold was fabricated by incorporating zinc oxide (ZnO) into potassium-sodium niobate (KNN) and composited with a poly (lactic-co-glycolic acid) (PLGA) to achieve multicombination antibacterial for bone infection. The physicochemical properties of piezoelectric antibacterial scaffolds were analyzed. Bacterial, cell, and animal experiments were performed to characterize the antibacterial and infection treatment capabilities of piezoelectric scaffolds. The piezoelectric properties of the PLGA/Zn-KNN scaffold were enhanced by embedding ZnO particles into the KNN solid solution matrix. Furthermore, the piezoelectric scaffold released zinc ions, and electrical stimulation driven by ultrasound resulted in significant antibacterial effects through direct and immunoregulatory antibacterial pathways. Mechanistic investigation suggested that extracellular matrix ligands and complement and coagulation cascades may have a moderate effect on macrophage phagocytosis. This work highlights potential application methods for fabricating novel antibacterial hybrid piezoelectric scaffolds and engineering macrophages with immunoregulatory antibacterial activity. |
| format | Article |
| id | doaj-art-7cc2da49ca4a48b3beb77a47d7ebb446 |
| institution | Kabale University |
| issn | 2452-199X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj-art-7cc2da49ca4a48b3beb77a47d7ebb4462025-01-28T04:14:48ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2025-05-0147295312An ultrasound-driven PLGA/Zn-KNN hybrid piezoelectric scaffold with direct and immunoregulatory antibacterial activity for bone infectionYuhao Zheng0Shu Wang1Wenhe Jin2Zhuoxuan Li3Guoju Yang4Xiaoxu Li5Ning Li6Yue Wang7Fan Sheng8Zhiming Song9Department of Sports Medicine, Orthopaedics Clinic, The First Hospital of Jilin University, Changchun, 130021, Jilin, PR ChinaDepartment of Radiotherapy, The Second Hospital of Jilin University, Changchun, 130041, Jilin, PR ChinaDepartment of Sports Medicine, Orthopaedics Clinic, The First Hospital of Jilin University, Changchun, 130021, Jilin, PR ChinaDepartment of Orthopedic Surgery, The Second Hospital of Jilin University, Changchun, 130000, Jilin, PR ChinaState Key Laboratory of Inorganic Synthesis & Preparative Chemistry, College of Chemistry, Jilin University, Changchun, 130012, Jilin, PR ChinaDepartment of Sports Medicine, Orthopaedics Clinic, The First Hospital of Jilin University, Changchun, 130021, Jilin, PR ChinaDepartment of Sports Medicine, Orthopaedics Clinic, The First Hospital of Jilin University, Changchun, 130021, Jilin, PR ChinaDepartment of Sports Medicine, Orthopaedics Clinic, The First Hospital of Jilin University, Changchun, 130021, Jilin, PR ChinaDepartment of Dermatology, The Second Hospital of Jilin University, Changchun, 130041, Jilin, PR China; Corresponding author.Department of Sports Medicine, Orthopaedics Clinic, The First Hospital of Jilin University, Changchun, 130021, Jilin, PR China; Corresponding author.Antibacterial piezoelectric materials have broad application prospects in the medical field because of their broad-spectrum antibacterial properties and no bacterial drug resistance. At present, one of the main problems in the application of piezoelectric materials is the low electrocatalytic efficiency, which limits its application in antibacterial field. In this study, a piezoelectric antibacterial (PLGA/Zn-KNN) scaffold was fabricated by incorporating zinc oxide (ZnO) into potassium-sodium niobate (KNN) and composited with a poly (lactic-co-glycolic acid) (PLGA) to achieve multicombination antibacterial for bone infection. The physicochemical properties of piezoelectric antibacterial scaffolds were analyzed. Bacterial, cell, and animal experiments were performed to characterize the antibacterial and infection treatment capabilities of piezoelectric scaffolds. The piezoelectric properties of the PLGA/Zn-KNN scaffold were enhanced by embedding ZnO particles into the KNN solid solution matrix. Furthermore, the piezoelectric scaffold released zinc ions, and electrical stimulation driven by ultrasound resulted in significant antibacterial effects through direct and immunoregulatory antibacterial pathways. Mechanistic investigation suggested that extracellular matrix ligands and complement and coagulation cascades may have a moderate effect on macrophage phagocytosis. This work highlights potential application methods for fabricating novel antibacterial hybrid piezoelectric scaffolds and engineering macrophages with immunoregulatory antibacterial activity.http://www.sciencedirect.com/science/article/pii/S2452199X2500026XUltrasoundPiezoelectric scaffoldImmunoregulatory antibacterialBoneInfection |
| spellingShingle | Yuhao Zheng Shu Wang Wenhe Jin Zhuoxuan Li Guoju Yang Xiaoxu Li Ning Li Yue Wang Fan Sheng Zhiming Song An ultrasound-driven PLGA/Zn-KNN hybrid piezoelectric scaffold with direct and immunoregulatory antibacterial activity for bone infection Bioactive Materials Ultrasound Piezoelectric scaffold Immunoregulatory antibacterial Bone Infection |
| title | An ultrasound-driven PLGA/Zn-KNN hybrid piezoelectric scaffold with direct and immunoregulatory antibacterial activity for bone infection |
| title_full | An ultrasound-driven PLGA/Zn-KNN hybrid piezoelectric scaffold with direct and immunoregulatory antibacterial activity for bone infection |
| title_fullStr | An ultrasound-driven PLGA/Zn-KNN hybrid piezoelectric scaffold with direct and immunoregulatory antibacterial activity for bone infection |
| title_full_unstemmed | An ultrasound-driven PLGA/Zn-KNN hybrid piezoelectric scaffold with direct and immunoregulatory antibacterial activity for bone infection |
| title_short | An ultrasound-driven PLGA/Zn-KNN hybrid piezoelectric scaffold with direct and immunoregulatory antibacterial activity for bone infection |
| title_sort | ultrasound driven plga zn knn hybrid piezoelectric scaffold with direct and immunoregulatory antibacterial activity for bone infection |
| topic | Ultrasound Piezoelectric scaffold Immunoregulatory antibacterial Bone Infection |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X2500026X |
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