Unusual Cushing’s Syndrome and Hypercalcitoninaemia due to a Small Cell Prostate Carcinoma
A 75-year-old man was hospitalized because of severe hypokalaemia due to ACTH dependent Cushing’s syndrome. Total body computed tomography (TBCT) and 68 Gallium DOTATATE PET/CT localized a voluminous prostate tumour. A subsequent transurethral prostate biopsy documented a small cell carcinoma positi...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2016/6308058 |
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| author | Antonio Balestrieri Elena Magnani Fiorella Nuzzo |
| author_facet | Antonio Balestrieri Elena Magnani Fiorella Nuzzo |
| author_sort | Antonio Balestrieri |
| collection | DOAJ |
| description | A 75-year-old man was hospitalized because of severe hypokalaemia due to ACTH dependent Cushing’s syndrome. Total body computed tomography (TBCT) and 68 Gallium DOTATATE PET/CT localized a voluminous prostate tumour. A subsequent transurethral prostate biopsy documented a small cell carcinoma positive for ACTH and calcitonin and negative for prostatic specific antigen (PSA) at immunocytochemical study; serum prostatic specific antigen (PSA) was normal. Despite medical treatments, Cushing’s syndrome was not controlled and the patient’s clinical condition progressively worsened. Surgical resection was excluded; the patient underwent a cycle of chemotherapy followed by febrile neutropenia and fatal intestinal perforation. This case report describes a rare case of Cushing’s syndrome and hypercalcitoninaemia due to a small cell carcinoma of the prostate, a rare tumour with very few therapeutic options and negative prognosis. |
| format | Article |
| id | doaj-art-7cb9f9aa303f461b89972091dbc8f1a6 |
| institution | Kabale University |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-7cb9f9aa303f461b89972091dbc8f1a62025-02-03T01:02:25ZengWileyCase Reports in Endocrinology2090-65012090-651X2016-01-01201610.1155/2016/63080586308058Unusual Cushing’s Syndrome and Hypercalcitoninaemia due to a Small Cell Prostate CarcinomaAntonio Balestrieri0Elena Magnani1Fiorella Nuzzo2Endocrinology and Diabetology Unit, “M. Bufalini” Hospital, ASL of Romagna, Cesena, ItalyInternal Medicine Unit, “M. Bufalini” Hospital, ASL of Romagna, Cesena, ItalyPathology Unit, “M. Bufalini” Hospital, ASL of Romagna, Cesena, ItalyA 75-year-old man was hospitalized because of severe hypokalaemia due to ACTH dependent Cushing’s syndrome. Total body computed tomography (TBCT) and 68 Gallium DOTATATE PET/CT localized a voluminous prostate tumour. A subsequent transurethral prostate biopsy documented a small cell carcinoma positive for ACTH and calcitonin and negative for prostatic specific antigen (PSA) at immunocytochemical study; serum prostatic specific antigen (PSA) was normal. Despite medical treatments, Cushing’s syndrome was not controlled and the patient’s clinical condition progressively worsened. Surgical resection was excluded; the patient underwent a cycle of chemotherapy followed by febrile neutropenia and fatal intestinal perforation. This case report describes a rare case of Cushing’s syndrome and hypercalcitoninaemia due to a small cell carcinoma of the prostate, a rare tumour with very few therapeutic options and negative prognosis.http://dx.doi.org/10.1155/2016/6308058 |
| spellingShingle | Antonio Balestrieri Elena Magnani Fiorella Nuzzo Unusual Cushing’s Syndrome and Hypercalcitoninaemia due to a Small Cell Prostate Carcinoma Case Reports in Endocrinology |
| title | Unusual Cushing’s Syndrome and Hypercalcitoninaemia due to a Small Cell Prostate Carcinoma |
| title_full | Unusual Cushing’s Syndrome and Hypercalcitoninaemia due to a Small Cell Prostate Carcinoma |
| title_fullStr | Unusual Cushing’s Syndrome and Hypercalcitoninaemia due to a Small Cell Prostate Carcinoma |
| title_full_unstemmed | Unusual Cushing’s Syndrome and Hypercalcitoninaemia due to a Small Cell Prostate Carcinoma |
| title_short | Unusual Cushing’s Syndrome and Hypercalcitoninaemia due to a Small Cell Prostate Carcinoma |
| title_sort | unusual cushing s syndrome and hypercalcitoninaemia due to a small cell prostate carcinoma |
| url | http://dx.doi.org/10.1155/2016/6308058 |
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