SOX9 predicts progression toward cirrhosis in patients while its loss protects against liver fibrosis

SOX9 predicts progression toward cirrhosis in patients while its loss protects against liver fibrosis

Abstract Fibrosis and organ failure is a common endpoint for many chronic liver diseases. Much is known about the upstream inflammatory mechanisms provoking fibrosis and downstream potential for tissue remodeling. However, less is known about the transcriptional regulation in vivo governing fibrotic...

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Main Authors: Varinder S Athwal, James Pritchett, Jessica Llewellyn, Katherine Martin, Elizabeth Camacho, Sayyid MA Raza, Alexander Phythian‐Adams, Lindsay J Birchall, Aoibheann F Mullan, Kim Su, Laurence Pearmain, Grace Dolman, Abed M Zaitoun, Scott L Friedman, Andrew MacDonald, William L Irving, Indra N Guha, Neil A Hanley, Karen Piper Hanley
Format: Article
Language:English
Published: Springer Nature 2017-11-01
Series:EMBO Molecular Medicine
Subjects:
extracellular matrix
hepatic stellate cells
liver fibrosis
SOX9
YAP1
Online Access:https://doi.org/10.15252/emmm.201707860
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https://doi.org/10.15252/emmm.201707860

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