Making Sense of Antisense
Since the identification of the DNA double-stranded helix, the gene as a target of therapy and, moreover, the use of DNA as a drug have been possibilities. ‘Antisense’ is used by some living organisms, specifically viruses, to control gene replication. Only recently, the use of antisense DNA as a me...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1999-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1999/154140 |
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| _version_ | 1832561153728839680 |
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| author | Bruce R Yacyshyn William R Shanahan |
| author_facet | Bruce R Yacyshyn William R Shanahan |
| author_sort | Bruce R Yacyshyn |
| collection | DOAJ |
| description | Since the identification of the DNA double-stranded helix, the gene as a target of therapy and, moreover, the use of DNA as a drug have been possibilities. ‘Antisense’ is used by some living organisms, specifically viruses, to control gene replication. Only recently, the use of antisense DNA as a mechanism to control human gene translation has been appreciated. A recent report on the use of systemically administered oligonucleotides in human Crohn’s disease is reviewed. DNA antisense oligonucleotides offer a technology capable of unique use at the laboratory bench as well as for highly specific therapeutic drugs. The conceptualization and possible future directions of these exciting compounds are reviewed. |
| format | Article |
| id | doaj-art-7ca94e60a8e44aeca913e4c81fa57b95 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 1999-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-7ca94e60a8e44aeca913e4c81fa57b952025-02-03T01:25:51ZengWileyCanadian Journal of Gastroenterology0835-79001999-01-0113974575110.1155/1999/154140Making Sense of AntisenseBruce R Yacyshyn0William R Shanahan1Division of Gastroenterology, University of Alberta, Edmonton, Alberta, CanadaISIS Pharmaceuticals, Inc, Carlsbad, California, USASince the identification of the DNA double-stranded helix, the gene as a target of therapy and, moreover, the use of DNA as a drug have been possibilities. ‘Antisense’ is used by some living organisms, specifically viruses, to control gene replication. Only recently, the use of antisense DNA as a mechanism to control human gene translation has been appreciated. A recent report on the use of systemically administered oligonucleotides in human Crohn’s disease is reviewed. DNA antisense oligonucleotides offer a technology capable of unique use at the laboratory bench as well as for highly specific therapeutic drugs. The conceptualization and possible future directions of these exciting compounds are reviewed.http://dx.doi.org/10.1155/1999/154140 |
| spellingShingle | Bruce R Yacyshyn William R Shanahan Making Sense of Antisense Canadian Journal of Gastroenterology |
| title | Making Sense of Antisense |
| title_full | Making Sense of Antisense |
| title_fullStr | Making Sense of Antisense |
| title_full_unstemmed | Making Sense of Antisense |
| title_short | Making Sense of Antisense |
| title_sort | making sense of antisense |
| url | http://dx.doi.org/10.1155/1999/154140 |
| work_keys_str_mv | AT bruceryacyshyn makingsenseofantisense AT williamrshanahan makingsenseofantisense |