Seroconversion Is Misleading as a Test for HSV-2 Infection in Prophylactic Genital Herpes Vaccine Trials: Results of Vaccine Studies in Guinea Pigs

Seroconversion Is Misleading as a Test for HSV-2 Infection in Prophylactic Genital Herpes Vaccine Trials: Results of Vaccine Studies in Guinea Pigs

Seroconversion is defined as a four-fold or greater rise in antibody titers. This assay is used in human prophylactic vaccine trials to confirm HSV as the cause of genital lesions and detect subclinical latent infection. We evaluated the accuracy of seroconversion in detecting infection using a guin...

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Bibliographic Details
Main Authors: Valerie Bromberg, Lauren M. Hook, John M. Lubinski, Zauraiz Syeda, Kevin P. Egan, Gary H. Cohen, Sita Awasthi, Harvey M. Friedman
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Viruses
Subjects:
seroconversion
gG2 ELISA
Western blot
HSV-2 vaccine
genital infection
genital lesions
Online Access:https://www.mdpi.com/1999-4915/17/6/773
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