Prion-induced ferroptosis is facilitated by RAC3

Prion-induced ferroptosis is facilitated by RAC3

Abstract Prions are infectious agents that initiate transmissible spongiform encephalopathies, causing devastating neuronal destruction in Creutzfeldt-Jakob and Kuru disease. Rapid cell death depends on presence of the endogenous prion protein PrPC, but its mechanistic contribution to pathogenesis i...

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Main Authors: Hao Peng, Susanne Pfeiffer, Borys Varynskyi, Marina Qiu, Chanikarn Srinark, Xiang Jin, Xin Zhang, Katie Williams, Bradley R. Groveman, Simote T. Foliaki, Brent Race, Tina Thomas, Chengxuan Chen, Constanze Müller, Krisztina Kovács, Thomas Arzberger, Stefan Momma, Cathryn L. Haigh, Joel A. Schick
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60793-3
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https://doi.org/10.1038/s41467-025-60793-3

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