Bexarotene ameliorated the pulmonary inflammation and M1 polarization of alveolar macrophages induced by cigarette smoke via PPARγ/HO-1

Bexarotene ameliorated the pulmonary inflammation and M1 polarization of alveolar macrophages induced by cigarette smoke via PPARγ/HO-1

Abstract Background Alveolar macrophages (AMs) modulate pulmonary inflammation in chronic obstructive pulmonary disease (COPD), contributing to its progression. The PPARγ/RXRα heterodimer influences AM polarization induced by cigarette smoke (CS). Although PPARγ agonists suppress CS-induced M1 macro...

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Bibliographic Details
Main Authors: Haoshen Feng, Zhe Li, Rui Zheng
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Respiratory Research
Subjects:
COPD
Cigarette smoke
Macrophage polarization
Bexarotene
PPARγ
Online Access:https://doi.org/10.1186/s12931-024-03064-x
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