A synthesized view of the CSF-blood barrier and its surgical implications for aging disorders
In this review, we explore the mechanisms of the blood-cerebrospinal fluid (CSF) barrier and CSF transport. We briefly review the mathematical framework for CSF transport as described by a set of well-studied partial differential equations. Moreover, we describe the major contributors of CSF flow th...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2024.1492449/full |
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| author | Birra Taha Robert McGovern Cornelius Lam Cornelius Lam |
| author_facet | Birra Taha Robert McGovern Cornelius Lam Cornelius Lam |
| author_sort | Birra Taha |
| collection | DOAJ |
| description | In this review, we explore the mechanisms of the blood-cerebrospinal fluid (CSF) barrier and CSF transport. We briefly review the mathematical framework for CSF transport as described by a set of well-studied partial differential equations. Moreover, we describe the major contributors of CSF flow through both diffusive and convective forces beginning at the molecular level and extending into macroscopic clinical observations. In addition, we review neurosurgical perspectives in understanding CSF outflow pathways. Finally, we discuss the implications of flow dysregulation in the context of neurodegenerative diseases and discuss the rising role of perivascular drainage pathways including glymphatics. |
| format | Article |
| id | doaj-art-7c8347752fad4e89a0d9fe319a16ce74 |
| institution | Kabale University |
| issn | 1663-4365 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj-art-7c8347752fad4e89a0d9fe319a16ce742025-02-05T07:31:55ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652025-02-011610.3389/fnagi.2024.14924491492449A synthesized view of the CSF-blood barrier and its surgical implications for aging disordersBirra Taha0Robert McGovern1Cornelius Lam2Cornelius Lam3Department of Neurosurgery, University of Minnesota, Minneapolis, MN, United StatesDepartment of Neurosurgery, University of Minnesota, Minneapolis, MN, United StatesDepartment of Neurosurgery, University of Minnesota, Minneapolis, MN, United StatesMinneapolis VA Health Care System, Veterans Health Administration, United States Department of Veterans Affairs, Minneapolis, MN, United StatesIn this review, we explore the mechanisms of the blood-cerebrospinal fluid (CSF) barrier and CSF transport. We briefly review the mathematical framework for CSF transport as described by a set of well-studied partial differential equations. Moreover, we describe the major contributors of CSF flow through both diffusive and convective forces beginning at the molecular level and extending into macroscopic clinical observations. In addition, we review neurosurgical perspectives in understanding CSF outflow pathways. Finally, we discuss the implications of flow dysregulation in the context of neurodegenerative diseases and discuss the rising role of perivascular drainage pathways including glymphatics.https://www.frontiersin.org/articles/10.3389/fnagi.2024.1492449/fullCSF (cerebrospinal fluid)hydrocephalusAlzheimer’s diseasechoroid plexusendoscopic third ventriculostomy (ETV) |
| spellingShingle | Birra Taha Robert McGovern Cornelius Lam Cornelius Lam A synthesized view of the CSF-blood barrier and its surgical implications for aging disorders Frontiers in Aging Neuroscience CSF (cerebrospinal fluid) hydrocephalus Alzheimer’s disease choroid plexus endoscopic third ventriculostomy (ETV) |
| title | A synthesized view of the CSF-blood barrier and its surgical implications for aging disorders |
| title_full | A synthesized view of the CSF-blood barrier and its surgical implications for aging disorders |
| title_fullStr | A synthesized view of the CSF-blood barrier and its surgical implications for aging disorders |
| title_full_unstemmed | A synthesized view of the CSF-blood barrier and its surgical implications for aging disorders |
| title_short | A synthesized view of the CSF-blood barrier and its surgical implications for aging disorders |
| title_sort | synthesized view of the csf blood barrier and its surgical implications for aging disorders |
| topic | CSF (cerebrospinal fluid) hydrocephalus Alzheimer’s disease choroid plexus endoscopic third ventriculostomy (ETV) |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2024.1492449/full |
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