Current Antibiotic Treatment and Outcome for Lower Respiratory Tract Infections

A number of national guidelines have been published to aid the antimicrobial management of community-acquired pneumonia. However, data on prescriptions for lower respiratory tract infection (LRTI) indicate considerable variation in the choice of first-line and subsequent therapy at national and loca...

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Main Authors: Alasdair P MacGowan, Tracey Halladay, Andrew M Lovering
Format: Article
Language:English
Published: Wiley 1998-01-01
Series:Canadian Journal of Infectious Diseases
Online Access:http://dx.doi.org/10.1155/1998/527248
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author Alasdair P MacGowan
Tracey Halladay
Andrew M Lovering
author_facet Alasdair P MacGowan
Tracey Halladay
Andrew M Lovering
author_sort Alasdair P MacGowan
collection DOAJ
description A number of national guidelines have been published to aid the antimicrobial management of community-acquired pneumonia. However, data on prescriptions for lower respiratory tract infection (LRTI) indicate considerable variation in the choice of first-line and subsequent therapy at national and local levels. Outcomes research in LRTI, whether based on clinical, economic or patient-focused criteria, is still evolving. Clinical outcomes are best studied for both pneumonia and exacerbation of chronic obstructive pulmonary disease. Economic evaluations often do not encompass all of the costs, for example, time off from work or the economic impact of antibacterial resistance. Duration of hospital stay is a good marker of costs for hospital providers and may be affected by age. marital status and comorbidities. Antibiotic choice may have an impact on the duration of hospital stay by increasing side effects, predisposing patients to hospitalacquired infection or reduced clinical efficacy. Patient expectation is largely unstudied in pulmonary infection.
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spelling doaj-art-7c7a04be7b5e4c1486f31230cc8360822025-02-03T01:23:07ZengWileyCanadian Journal of Infectious Diseases1180-23321998-01-019Suppl E30E34E10.1155/1998/527248Current Antibiotic Treatment and Outcome for Lower Respiratory Tract InfectionsAlasdair P MacGowan0Tracey Halladay1Andrew M Lovering2Bristol Centre for Antimicrobial Research & Evaluation, Department ef Medical Microbiology, Southmead Hospital, Westbury-on-Trym, Bristol, UKBristol Centre for Antimicrobial Research & Evaluation, Department ef Medical Microbiology, Southmead Hospital, Westbury-on-Trym, Bristol, UKBristol Centre for Antimicrobial Research & Evaluation, Department ef Medical Microbiology, Southmead Hospital, Westbury-on-Trym, Bristol, UKA number of national guidelines have been published to aid the antimicrobial management of community-acquired pneumonia. However, data on prescriptions for lower respiratory tract infection (LRTI) indicate considerable variation in the choice of first-line and subsequent therapy at national and local levels. Outcomes research in LRTI, whether based on clinical, economic or patient-focused criteria, is still evolving. Clinical outcomes are best studied for both pneumonia and exacerbation of chronic obstructive pulmonary disease. Economic evaluations often do not encompass all of the costs, for example, time off from work or the economic impact of antibacterial resistance. Duration of hospital stay is a good marker of costs for hospital providers and may be affected by age. marital status and comorbidities. Antibiotic choice may have an impact on the duration of hospital stay by increasing side effects, predisposing patients to hospitalacquired infection or reduced clinical efficacy. Patient expectation is largely unstudied in pulmonary infection.http://dx.doi.org/10.1155/1998/527248
spellingShingle Alasdair P MacGowan
Tracey Halladay
Andrew M Lovering
Current Antibiotic Treatment and Outcome for Lower Respiratory Tract Infections
Canadian Journal of Infectious Diseases
title Current Antibiotic Treatment and Outcome for Lower Respiratory Tract Infections
title_full Current Antibiotic Treatment and Outcome for Lower Respiratory Tract Infections
title_fullStr Current Antibiotic Treatment and Outcome for Lower Respiratory Tract Infections
title_full_unstemmed Current Antibiotic Treatment and Outcome for Lower Respiratory Tract Infections
title_short Current Antibiotic Treatment and Outcome for Lower Respiratory Tract Infections
title_sort current antibiotic treatment and outcome for lower respiratory tract infections
url http://dx.doi.org/10.1155/1998/527248
work_keys_str_mv AT alasdairpmacgowan currentantibiotictreatmentandoutcomeforlowerrespiratorytractinfections
AT traceyhalladay currentantibiotictreatmentandoutcomeforlowerrespiratorytractinfections
AT andrewmlovering currentantibiotictreatmentandoutcomeforlowerrespiratorytractinfections