Evaluation of an Antisense Oligonucleotide Targeting CAG Repeats: A Patient-Customized Therapy Study for Huntington’s Disease

Evaluation of an Antisense Oligonucleotide Targeting CAG Repeats: A Patient-Customized Therapy Study for Huntington’s Disease

Huntington’s disease is a genetic disorder characterized by progressive neuronal cell damage in some areas of the brain; symptoms are commonly associated with chorea, rigidity and dystonia. The symptoms in Huntington’s Disease are caused by a pathological increase in the number of Cytokine-Adenine-G...

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Bibliographic Details
Main Authors: Sergio Adrian Ocampo-Ortega, Vivany Maydel Sierra-Sanchez, Citlali Margarita Blancas-Napoles, Asdrúbal González-Carteño, Elvia Mera-Jiménez, Martha Edith Macías-Pérez, Adriana Hernandez-Guerra, Rodrigo Romero-Nava, Fengyang Huang, Enrique Hong, Santiago Villafaña
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Life
Subjects:
CAG cluster
Huntington’s disease
Huntingtin
long antisense oligonucleotide
Online Access:https://www.mdpi.com/2075-1729/14/12/1607
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