Hyperbilirubinemia: Does It Matter?
Serum bilirubin concentrations are increased in several hematological and hepatic disorders; however, hyperbilirubinemia, often of familial origin, may occur without overt signs of hemolysis or evident liver disease. The authors review briefly the main steps of hepatic bilirubin metabolism, then dis...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1999-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1999/648498 |
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| _version_ | 1832554021469028352 |
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| author | Lajos Okolicsanyi Giulia Martina Cavestro Claudia Guatti-Zuliani |
| author_facet | Lajos Okolicsanyi Giulia Martina Cavestro Claudia Guatti-Zuliani |
| author_sort | Lajos Okolicsanyi |
| collection | DOAJ |
| description | Serum bilirubin concentrations are increased in several hematological and hepatic disorders; however, hyperbilirubinemia, often of familial origin, may occur without overt signs of hemolysis or evident liver disease. The authors review briefly the main steps of hepatic bilirubin metabolism, then discuss the pathogenetic mechanisms of the different forms of familial hyperbilirubinemia. The knowledge of these conditions is increasingly important because orthotopic liver transplantation may be a therapeutic choice for some severe forms. Furthermore, early diagnosis is necessary to avoid unnecessary medical investigations for the otherwise relatively common, benign unconjugated hyperbilirubinemia. Finally, individuals with unmasked defective bilirubin handling may be potential liver donors; thus, unexplained jaundice occurring after orthotopic liver transplantation may be related to this disorder. |
| format | Article |
| id | doaj-art-7c6c1144b53c4bc1ab6c20cc7441a741 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 1999-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-7c6c1144b53c4bc1ab6c20cc7441a7412025-02-03T05:52:33ZengWileyCanadian Journal of Gastroenterology0835-79001999-01-0113866366810.1155/1999/648498Hyperbilirubinemia: Does It Matter?Lajos OkolicsanyiGiulia Martina CavestroClaudia Guatti-ZulianiSerum bilirubin concentrations are increased in several hematological and hepatic disorders; however, hyperbilirubinemia, often of familial origin, may occur without overt signs of hemolysis or evident liver disease. The authors review briefly the main steps of hepatic bilirubin metabolism, then discuss the pathogenetic mechanisms of the different forms of familial hyperbilirubinemia. The knowledge of these conditions is increasingly important because orthotopic liver transplantation may be a therapeutic choice for some severe forms. Furthermore, early diagnosis is necessary to avoid unnecessary medical investigations for the otherwise relatively common, benign unconjugated hyperbilirubinemia. Finally, individuals with unmasked defective bilirubin handling may be potential liver donors; thus, unexplained jaundice occurring after orthotopic liver transplantation may be related to this disorder.http://dx.doi.org/10.1155/1999/648498 |
| spellingShingle | Lajos Okolicsanyi Giulia Martina Cavestro Claudia Guatti-Zuliani Hyperbilirubinemia: Does It Matter? Canadian Journal of Gastroenterology |
| title | Hyperbilirubinemia: Does It Matter? |
| title_full | Hyperbilirubinemia: Does It Matter? |
| title_fullStr | Hyperbilirubinemia: Does It Matter? |
| title_full_unstemmed | Hyperbilirubinemia: Does It Matter? |
| title_short | Hyperbilirubinemia: Does It Matter? |
| title_sort | hyperbilirubinemia does it matter |
| url | http://dx.doi.org/10.1155/1999/648498 |
| work_keys_str_mv | AT lajosokolicsanyi hyperbilirubinemiadoesitmatter AT giuliamartinacavestro hyperbilirubinemiadoesitmatter AT claudiaguattizuliani hyperbilirubinemiadoesitmatter |