Echocardiographic evaluation of healthy cats under the effect of Dexmedetomidine and Butorphanol
ABSTRACT The study aimed to evaluate the applicability of the association of two classes of drugs. Ten healthy cats were used, who underwent echocardiographic evaluation and measurement of systemic blood pressure at baseline and after administration of dexmedetomidine at a dose of (10 mcg/kg) and bu...
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Universidade Federal de Minas Gerais
2025-01-01
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| Series: | Arquivo Brasileiro de Medicina Veterinária e Zootecnia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352025000100100&lng=en&tlng=en |
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| author | L.I. Pereira M.C.R. Milano C.H. Oliveira A.M. Amude A.K. Fabretti D.A.G. Kemper |
| author_facet | L.I. Pereira M.C.R. Milano C.H. Oliveira A.M. Amude A.K. Fabretti D.A.G. Kemper |
| author_sort | L.I. Pereira |
| collection | DOAJ |
| description | ABSTRACT The study aimed to evaluate the applicability of the association of two classes of drugs. Ten healthy cats were used, who underwent echocardiographic evaluation and measurement of systemic blood pressure at baseline and after administration of dexmedetomidine at a dose of (10 mcg/kg) and butorphanol at a dose of (0.4mg/kg) intramuscularly. In the results obtained, there was a 12% decrease in free wall thickness in diastole in M mode (p=0.017), in addition to a 47% decrease in heart rate (p< 0.0001) and a 30% increase in systemic blood pressure (p<0.0001) after sedation. The TEI index increased (p<0.0001) and there was a significant impact on the systolic function of sedated cats, with a decrease in shortening fraction (p<0.0001), cardiac output (p = 20.003), S' wave (p = 0.007) and increased left ventricular diameter in M-mode systole (p = 0.0003). And the maximum velocities of the aorta (p = 0.015) and pulmonary artery (p < 0.0001) flows decreased, in addition to promoting alterations compatible with pulmonary artery hypertension. The association promotes sedation, but decreases systolic function, cardiac output and heart rate and increases afterload, therefore it is not suitable for echocardiographic evaluation. |
| format | Article |
| id | doaj-art-7c4eb18c760046ff857aee232187a9b8 |
| institution | Kabale University |
| issn | 1678-4162 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Universidade Federal de Minas Gerais |
| record_format | Article |
| series | Arquivo Brasileiro de Medicina Veterinária e Zootecnia |
| spelling | doaj-art-7c4eb18c760046ff857aee232187a9b82025-01-21T07:37:06ZengUniversidade Federal de Minas GeraisArquivo Brasileiro de Medicina Veterinária e Zootecnia1678-41622025-01-0177110.1590/1678-4162-13090Echocardiographic evaluation of healthy cats under the effect of Dexmedetomidine and ButorphanolL.I. Pereirahttps://orcid.org/0000-0001-6975-0801M.C.R. Milanohttps://orcid.org/0009-0007-4198-7998C.H. Oliveirahttps://orcid.org/0009-0008-3277-033XA.M. Amudehttps://orcid.org/0000-0001-7515-7537A.K. Fabrettihttps://orcid.org/0000-0002-6487-823XD.A.G. Kemperhttps://orcid.org/0000-0002-4331-7572ABSTRACT The study aimed to evaluate the applicability of the association of two classes of drugs. Ten healthy cats were used, who underwent echocardiographic evaluation and measurement of systemic blood pressure at baseline and after administration of dexmedetomidine at a dose of (10 mcg/kg) and butorphanol at a dose of (0.4mg/kg) intramuscularly. In the results obtained, there was a 12% decrease in free wall thickness in diastole in M mode (p=0.017), in addition to a 47% decrease in heart rate (p< 0.0001) and a 30% increase in systemic blood pressure (p<0.0001) after sedation. The TEI index increased (p<0.0001) and there was a significant impact on the systolic function of sedated cats, with a decrease in shortening fraction (p<0.0001), cardiac output (p = 20.003), S' wave (p = 0.007) and increased left ventricular diameter in M-mode systole (p = 0.0003). And the maximum velocities of the aorta (p = 0.015) and pulmonary artery (p < 0.0001) flows decreased, in addition to promoting alterations compatible with pulmonary artery hypertension. The association promotes sedation, but decreases systolic function, cardiac output and heart rate and increases afterload, therefore it is not suitable for echocardiographic evaluation.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352025000100100&lng=en&tlng=enfelinecardiologyα2-agonist |
| spellingShingle | L.I. Pereira M.C.R. Milano C.H. Oliveira A.M. Amude A.K. Fabretti D.A.G. Kemper Echocardiographic evaluation of healthy cats under the effect of Dexmedetomidine and Butorphanol Arquivo Brasileiro de Medicina Veterinária e Zootecnia feline cardiology α2-agonist |
| title | Echocardiographic evaluation of healthy cats under the effect of Dexmedetomidine and Butorphanol |
| title_full | Echocardiographic evaluation of healthy cats under the effect of Dexmedetomidine and Butorphanol |
| title_fullStr | Echocardiographic evaluation of healthy cats under the effect of Dexmedetomidine and Butorphanol |
| title_full_unstemmed | Echocardiographic evaluation of healthy cats under the effect of Dexmedetomidine and Butorphanol |
| title_short | Echocardiographic evaluation of healthy cats under the effect of Dexmedetomidine and Butorphanol |
| title_sort | echocardiographic evaluation of healthy cats under the effect of dexmedetomidine and butorphanol |
| topic | feline cardiology α2-agonist |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352025000100100&lng=en&tlng=en |
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