Porcine transient receptor potential channel 1 promotes adipogenesis and lipid deposition
Adipose tissue, an important organ involved in energy metabolism and endocrine, is closely related to animal meat quality and human health. Transient receptor potential channel 1 (TRPC1), an ion transporter, is adipocytes’ major Ca2+ entry channel. However, its function in fat deposition is poorly u...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | Journal of Lipid Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227524002232 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832582241534869504 |
|---|---|
| author | Yu Fu Xin Hao Jingru Nie Peng Shang Xinxing Dong Bo Zhang Dawei Yan Hao Zhang |
| author_facet | Yu Fu Xin Hao Jingru Nie Peng Shang Xinxing Dong Bo Zhang Dawei Yan Hao Zhang |
| author_sort | Yu Fu |
| collection | DOAJ |
| description | Adipose tissue, an important organ involved in energy metabolism and endocrine, is closely related to animal meat quality and human health. Transient receptor potential channel 1 (TRPC1), an ion transporter, is adipocytes’ major Ca2+ entry channel. However, its function in fat deposition is poorly understood, particularly in pigs, which are both an ideal model for human obesity research and a primary meat source for human diets. In the present investigation, our findings demonstrate a prominent expression of TRPC1 within the adipose tissue of pigs with a strong fat deposition ability. Functional analysis showed that TRPC1 promotes primary preadipocyte proliferation and adipogenic differentiation. In vivo, transgenic mice expressing porcine TRPC1 exhibited aggravated high-fat diet–induced obesity, hepatic steatosis, and insulin resistance. Moreover, TRPC1 may facilitate adipogenesis via activating phosphatidylinositol 3 kinase/AKT and β-catenin signaling pathways. Our research underscores the pivotal role of porcine TRPC1 as a positive regulator in adipogenesis and lipid accumulation processes, providing a potential target for improving animal meat quality and treating obesity-related diseases in humans. |
| format | Article |
| id | doaj-art-7c4d140e9a6845df9fed1d1055823a97 |
| institution | Kabale University |
| issn | 0022-2275 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj-art-7c4d140e9a6845df9fed1d1055823a972025-01-30T05:12:39ZengElsevierJournal of Lipid Research0022-22752025-01-01661100718Porcine transient receptor potential channel 1 promotes adipogenesis and lipid depositionYu Fu0Xin Hao1Jingru Nie2Peng Shang3Xinxing Dong4Bo Zhang5Dawei Yan6Hao Zhang7Frontiers Science Center for Molecular Design Breeding (MOE), China Agricultural University, Beijing, China; State Key Laboratory of Animal Biotech Breeding, China Agricultural University, Beijing, ChinaState Key Laboratory of Animal Biotech Breeding, China Agricultural University, Beijing, ChinaState Key Laboratory of Animal Biotech Breeding, China Agricultural University, Beijing, ChinaCollege of Animal Science, Xizang Agricultural and Animal Husbandry College, Linzhi, ChinaCollege of Animal Science and Technology, Yunnan Agricultural University, Kunming, ChinaFrontiers Science Center for Molecular Design Breeding (MOE), China Agricultural University, Beijing, China; State Key Laboratory of Animal Biotech Breeding, China Agricultural University, Beijing, ChinaCollege of Animal Science and Technology, Yunnan Agricultural University, Kunming, ChinaFrontiers Science Center for Molecular Design Breeding (MOE), China Agricultural University, Beijing, China; State Key Laboratory of Animal Biotech Breeding, China Agricultural University, Beijing, China; For correspondence: Hao ZhangAdipose tissue, an important organ involved in energy metabolism and endocrine, is closely related to animal meat quality and human health. Transient receptor potential channel 1 (TRPC1), an ion transporter, is adipocytes’ major Ca2+ entry channel. However, its function in fat deposition is poorly understood, particularly in pigs, which are both an ideal model for human obesity research and a primary meat source for human diets. In the present investigation, our findings demonstrate a prominent expression of TRPC1 within the adipose tissue of pigs with a strong fat deposition ability. Functional analysis showed that TRPC1 promotes primary preadipocyte proliferation and adipogenic differentiation. In vivo, transgenic mice expressing porcine TRPC1 exhibited aggravated high-fat diet–induced obesity, hepatic steatosis, and insulin resistance. Moreover, TRPC1 may facilitate adipogenesis via activating phosphatidylinositol 3 kinase/AKT and β-catenin signaling pathways. Our research underscores the pivotal role of porcine TRPC1 as a positive regulator in adipogenesis and lipid accumulation processes, providing a potential target for improving animal meat quality and treating obesity-related diseases in humans.http://www.sciencedirect.com/science/article/pii/S0022227524002232porcineTRPC1adipogenesislipid depositionPI3K/AKTβ-catenin |
| spellingShingle | Yu Fu Xin Hao Jingru Nie Peng Shang Xinxing Dong Bo Zhang Dawei Yan Hao Zhang Porcine transient receptor potential channel 1 promotes adipogenesis and lipid deposition Journal of Lipid Research porcine TRPC1 adipogenesis lipid deposition PI3K/AKT β-catenin |
| title | Porcine transient receptor potential channel 1 promotes adipogenesis and lipid deposition |
| title_full | Porcine transient receptor potential channel 1 promotes adipogenesis and lipid deposition |
| title_fullStr | Porcine transient receptor potential channel 1 promotes adipogenesis and lipid deposition |
| title_full_unstemmed | Porcine transient receptor potential channel 1 promotes adipogenesis and lipid deposition |
| title_short | Porcine transient receptor potential channel 1 promotes adipogenesis and lipid deposition |
| title_sort | porcine transient receptor potential channel 1 promotes adipogenesis and lipid deposition |
| topic | porcine TRPC1 adipogenesis lipid deposition PI3K/AKT β-catenin |
| url | http://www.sciencedirect.com/science/article/pii/S0022227524002232 |
| work_keys_str_mv | AT yufu porcinetransientreceptorpotentialchannel1promotesadipogenesisandlipiddeposition AT xinhao porcinetransientreceptorpotentialchannel1promotesadipogenesisandlipiddeposition AT jingrunie porcinetransientreceptorpotentialchannel1promotesadipogenesisandlipiddeposition AT pengshang porcinetransientreceptorpotentialchannel1promotesadipogenesisandlipiddeposition AT xinxingdong porcinetransientreceptorpotentialchannel1promotesadipogenesisandlipiddeposition AT bozhang porcinetransientreceptorpotentialchannel1promotesadipogenesisandlipiddeposition AT daweiyan porcinetransientreceptorpotentialchannel1promotesadipogenesisandlipiddeposition AT haozhang porcinetransientreceptorpotentialchannel1promotesadipogenesisandlipiddeposition |