Identification and development of TRPM4 antagonists to counteract neuronal excitotoxicity

Identification and development of TRPM4 antagonists to counteract neuronal excitotoxicity

Summary: Neurodegeneration in central nervous system disorders is linked to dysregulated neuronal calcium. Direct inhibition of glutamate-induced neuronal calcium influx, particularly via N-methyl-D-aspartate receptors (NMDAR), has led to adverse effects and clinical trial failures. A more feasible...

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Main Authors: Lars Binkle-Ladisch, Andy Pironet, Andrea Zaliani, Chantal Alcouffe, Daniel Mensching, Undine Haferkamp, Anne Willing, Marcel S. Woo, Alexandre Erdmann, Timm Jessen, Stephen D. Hess, Philip Gribbon, Ole Pless, Rudi Vennekens, Manuel A. Friese
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:iScience
Subjects:
Molecular biology
Neuroscience
Molecular neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224026506
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http://www.sciencedirect.com/science/article/pii/S2589004224026506

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