Harnessing natural polymers and nanoparticles: Synergistic scaffold design for improved wound healing
Skin health is a vital indicator of overall well-being, notably influencing emotional and psychological states. Skin injuries which include, burns and diabetic, venous, and pressure ulcers are significant concerns in health care that are often demanding for appropriate management programs. Skin inju...
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| Language: | English |
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Elsevier
2025-03-01
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| Series: | Hybrid Advances |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2773207X25000053 |
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| author | Anitha S Nandini Robin Nadar Srividya Shivakumar Sharma S C Siddharth P Surekha Varalakshmi V Rajesh Lenka Rajadurai S |
| author_facet | Anitha S Nandini Robin Nadar Srividya Shivakumar Sharma S C Siddharth P Surekha Varalakshmi V Rajesh Lenka Rajadurai S |
| author_sort | Anitha S |
| collection | DOAJ |
| description | Skin health is a vital indicator of overall well-being, notably influencing emotional and psychological states. Skin injuries which include, burns and diabetic, venous, and pressure ulcers are significant concerns in health care that are often demanding for appropriate management programs. Skin injuries may be due to acute or chronic trauma, infections, and operations and can cause severe dysfunction or death. Hence, early clinical intervention becomes crucial in managing the problem. Wound care involves many strategies from simple local dressing to complex debridement techniques such as bioactive dressings and skin grafting. Conventional wound healing products do not heal wounds adequately and can cause scarring, suggesting the possibility of new biomaterials. The current developments of applying natural polymers, which are large organic compounds obtained from renewable resources, have revealed potential utilization in biomedicine due to their inherent antibacterial and antioxidant features. These polymers are biocompatible, biodegradable, and nontoxic to the environment, therefore of great importance in developing sustainable products. The incorporation of nanoparticles brings beneficial changes to natural polymers where the antibacterial, anti-inflammatory, and mechanical property is improved. The synergistic approach results in novel scaffold designs that promote cell functions and mimic the extracellular matrix (ECM) to further enhance wound healing. The present review aims to emphasize the potential and application of natural polymers in wound treatment. |
| format | Article |
| id | doaj-art-7c3ac32fe59c4c83ae37d3899dae0315 |
| institution | Kabale University |
| issn | 2773-207X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Hybrid Advances |
| spelling | doaj-art-7c3ac32fe59c4c83ae37d3899dae03152025-01-18T05:05:39ZengElsevierHybrid Advances2773-207X2025-03-018100381Harnessing natural polymers and nanoparticles: Synergistic scaffold design for improved wound healingAnitha S0Nandini Robin Nadar1Srividya Shivakumar2Sharma S C3Siddharth P4Surekha Varalakshmi V5Rajesh Lenka6Rajadurai S7Department of Microbiology and Botany, School of Sciences, JC road campus, Jain (Deemed-to-be University), India; Dr. Chenraj Roy Chand R & D centre, Jain College, V.V. Puram, Bangalore, 560004, India; Corresponding author.Department of Microbiology and Botany, School of Sciences, JC road campus, Jain (Deemed-to-be University), India.International Institute of Aerospace Engineering and Management (IIAEM), Jain Global Campus, Bengaluru, 562112, India; Dr. Chenraj Roy Chand R & D centre, Jain College, V.V. Puram, Bangalore, 560004, IndiaSchool of Allied Healthcare and Sciences, Whitefield campus, Jain (Deemed-to-be University), India; Corresponding author.Law and Forensic Materials, Jain University, Bangalore, India; Dr. Chenraj Roy Chand R & D centre, Jain College, V.V. Puram, Bangalore, 560004, IndiaGeneral Medicine, Mahatma Gandhi Medical Research Institute, Sri Balaji Vidyapeeth, Pondicherry Campus, Pondicherry, 607402, IndiaDept. of Physiology, Faculty of Allied Health Sciences & Dean Research, Meenakshi Academy of Higher Education and Research, Chennai, 600 078, IndiaDepartment of Microbiology, IMS & SUM Hospital, SOA University, Bhubaneswar, Odisha, 751003, IndiaDepartment of Orthopaedics, Meenakshi Medical College Hospital and Research Institute, Meenakshi Academy of Higher Education & Research, Chennai, 600078, IndiaSkin health is a vital indicator of overall well-being, notably influencing emotional and psychological states. Skin injuries which include, burns and diabetic, venous, and pressure ulcers are significant concerns in health care that are often demanding for appropriate management programs. Skin injuries may be due to acute or chronic trauma, infections, and operations and can cause severe dysfunction or death. Hence, early clinical intervention becomes crucial in managing the problem. Wound care involves many strategies from simple local dressing to complex debridement techniques such as bioactive dressings and skin grafting. Conventional wound healing products do not heal wounds adequately and can cause scarring, suggesting the possibility of new biomaterials. The current developments of applying natural polymers, which are large organic compounds obtained from renewable resources, have revealed potential utilization in biomedicine due to their inherent antibacterial and antioxidant features. These polymers are biocompatible, biodegradable, and nontoxic to the environment, therefore of great importance in developing sustainable products. The incorporation of nanoparticles brings beneficial changes to natural polymers where the antibacterial, anti-inflammatory, and mechanical property is improved. The synergistic approach results in novel scaffold designs that promote cell functions and mimic the extracellular matrix (ECM) to further enhance wound healing. The present review aims to emphasize the potential and application of natural polymers in wound treatment.http://www.sciencedirect.com/science/article/pii/S2773207X25000053Natural polymersWound healingSilver nanoparticleScar reductionBiocompatible |
| spellingShingle | Anitha S Nandini Robin Nadar Srividya Shivakumar Sharma S C Siddharth P Surekha Varalakshmi V Rajesh Lenka Rajadurai S Harnessing natural polymers and nanoparticles: Synergistic scaffold design for improved wound healing Hybrid Advances Natural polymers Wound healing Silver nanoparticle Scar reduction Biocompatible |
| title | Harnessing natural polymers and nanoparticles: Synergistic scaffold design for improved wound healing |
| title_full | Harnessing natural polymers and nanoparticles: Synergistic scaffold design for improved wound healing |
| title_fullStr | Harnessing natural polymers and nanoparticles: Synergistic scaffold design for improved wound healing |
| title_full_unstemmed | Harnessing natural polymers and nanoparticles: Synergistic scaffold design for improved wound healing |
| title_short | Harnessing natural polymers and nanoparticles: Synergistic scaffold design for improved wound healing |
| title_sort | harnessing natural polymers and nanoparticles synergistic scaffold design for improved wound healing |
| topic | Natural polymers Wound healing Silver nanoparticle Scar reduction Biocompatible |
| url | http://www.sciencedirect.com/science/article/pii/S2773207X25000053 |
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