The influence of infectious diseases on population genetics
Malaria is the vector-transmitted disease that causes the highestmorbidity and mortality in humans. Motivated by the known influenceof sickle-cell anemia on the morbidity and mortality ofmalaria-infected humans, we study the effect of malaria on the genetic composition of a host (human) population w...
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AIMS Press
2006-04-01
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| Series: | Mathematical Biosciences and Engineering |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2006.3.467 |
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| author | Zhilan Feng Carlos Castillo-Chavez |
| author_facet | Zhilan Feng Carlos Castillo-Chavez |
| author_sort | Zhilan Feng |
| collection | DOAJ |
| description | Malaria is the vector-transmitted disease that causes the highestmorbidity and mortality in humans. Motivated by the known influenceof sickle-cell anemia on the morbidity and mortality ofmalaria-infected humans, we study the effect of malaria on the genetic composition of a host (human) population where sickle-cell anemia is prevalent and malaria is endemic. The host subpopulations are therefore classified according to three genotypes, $A$$A$, $AS$, and $SS$. It is known that $A$$A$ malaria-infected individuals experience higher malaria-induced mortality than $AS$ or $SS$ individuals. However, individuals carrying the $S$ gene are known to experience a higher mortality rate in a malaria-free environment than those who lack such a gene. The tradeoffs between increased fitness for some types in the presence of disease (a population level process) and reduced fitness in a disease-free environment are explored in this manuscript. We start from the published results of an earlier model and proceed to remove some model restrictions in order to better understand the impact on the natural hosts' genetics in an environment where malaria is endemic. |
| format | Article |
| id | doaj-art-7c187ae468c54c1d8fb523a2c07626c6 |
| institution | Kabale University |
| issn | 1551-0018 |
| language | English |
| publishDate | 2006-04-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | Mathematical Biosciences and Engineering |
| spelling | doaj-art-7c187ae468c54c1d8fb523a2c07626c62025-01-24T01:51:49ZengAIMS PressMathematical Biosciences and Engineering1551-00182006-04-013346748310.3934/mbe.2006.3.467The influence of infectious diseases on population geneticsZhilan Feng0Carlos Castillo-Chavez1Department of Mathematics, Purdue University, West Lafayette, IN 47907Department of Mathematics, Purdue University, West Lafayette, IN 47907Malaria is the vector-transmitted disease that causes the highestmorbidity and mortality in humans. Motivated by the known influenceof sickle-cell anemia on the morbidity and mortality ofmalaria-infected humans, we study the effect of malaria on the genetic composition of a host (human) population where sickle-cell anemia is prevalent and malaria is endemic. The host subpopulations are therefore classified according to three genotypes, $A$$A$, $AS$, and $SS$. It is known that $A$$A$ malaria-infected individuals experience higher malaria-induced mortality than $AS$ or $SS$ individuals. However, individuals carrying the $S$ gene are known to experience a higher mortality rate in a malaria-free environment than those who lack such a gene. The tradeoffs between increased fitness for some types in the presence of disease (a population level process) and reduced fitness in a disease-free environment are explored in this manuscript. We start from the published results of an earlier model and proceed to remove some model restrictions in order to better understand the impact on the natural hosts' genetics in an environment where malaria is endemic.https://www.aimspress.com/article/doi/10.3934/mbe.2006.3.467mathematical modelinfectious diseasespopulation geneticsfast andslow dynamics. |
| spellingShingle | Zhilan Feng Carlos Castillo-Chavez The influence of infectious diseases on population genetics Mathematical Biosciences and Engineering mathematical model infectious diseases population genetics fast andslow dynamics. |
| title | The influence of infectious diseases on population genetics |
| title_full | The influence of infectious diseases on population genetics |
| title_fullStr | The influence of infectious diseases on population genetics |
| title_full_unstemmed | The influence of infectious diseases on population genetics |
| title_short | The influence of infectious diseases on population genetics |
| title_sort | influence of infectious diseases on population genetics |
| topic | mathematical model infectious diseases population genetics fast andslow dynamics. |
| url | https://www.aimspress.com/article/doi/10.3934/mbe.2006.3.467 |
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