Cerebral Blood Flow Alterations in High Myopia: An Arterial Spin Labeling Study
Objective. The aim of this study was to explore cerebral blood flow (CBF) alterations in subjects with high myopia (HM) using three-dimensional pseudocontinuous arterial spin labeling (3D-pcASL). Methods. A total of sixteen patients with bilateral HM and sixteen age- and sex-matched healthy controls...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2020/6090262 |
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| _version_ | 1832553269814099968 |
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| author | Huihui Wang Shanshan Li Xi Chen Yanling Wang Jing Li Zhenchang Wang |
| author_facet | Huihui Wang Shanshan Li Xi Chen Yanling Wang Jing Li Zhenchang Wang |
| author_sort | Huihui Wang |
| collection | DOAJ |
| description | Objective. The aim of this study was to explore cerebral blood flow (CBF) alterations in subjects with high myopia (HM) using three-dimensional pseudocontinuous arterial spin labeling (3D-pcASL). Methods. A total of sixteen patients with bilateral HM and sixteen age- and sex-matched healthy controls (HCs) were recruited. All subjects were right-handed. Image data preprocessing was performed using SPM8 and the DPABI toolbox. Clinical parameters were acquired in the HM group. Two-sample t-tests and Pearson correlation analysis were applied in this study. Results. Compared to HCs, patients with HM exhibited significantly increased CBF in the bilateral cerebellum, and no decreases in CBF were detected in the brain. However, no relationship was found between the mean CBF values in the different brain areas and the disease duration (P>0.05). Conclusions. Using ASL analysis, we detected aberrant blood perfusion in the cerebellum in HM patients, contributing to a better understanding of brain abnormalities and brain plasticity through a different perspective. |
| format | Article |
| id | doaj-art-7c14fcd83d874d81bca65649ee820fea |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-7c14fcd83d874d81bca65649ee820fea2025-02-03T05:54:26ZengWileyNeural Plasticity2090-59041687-54432020-01-01202010.1155/2020/60902626090262Cerebral Blood Flow Alterations in High Myopia: An Arterial Spin Labeling StudyHuihui Wang0Shanshan Li1Xi Chen2Yanling Wang3Jing Li4Zhenchang Wang5Department of Radiology, Beijing Friendship Hospital, Capital Medical University, ChinaDepartment of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, ChinaDepartment of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, ChinaDepartment of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, ChinaDepartment of Radiology, Beijing Friendship Hospital, Capital Medical University, ChinaDepartment of Radiology, Beijing Friendship Hospital, Capital Medical University, ChinaObjective. The aim of this study was to explore cerebral blood flow (CBF) alterations in subjects with high myopia (HM) using three-dimensional pseudocontinuous arterial spin labeling (3D-pcASL). Methods. A total of sixteen patients with bilateral HM and sixteen age- and sex-matched healthy controls (HCs) were recruited. All subjects were right-handed. Image data preprocessing was performed using SPM8 and the DPABI toolbox. Clinical parameters were acquired in the HM group. Two-sample t-tests and Pearson correlation analysis were applied in this study. Results. Compared to HCs, patients with HM exhibited significantly increased CBF in the bilateral cerebellum, and no decreases in CBF were detected in the brain. However, no relationship was found between the mean CBF values in the different brain areas and the disease duration (P>0.05). Conclusions. Using ASL analysis, we detected aberrant blood perfusion in the cerebellum in HM patients, contributing to a better understanding of brain abnormalities and brain plasticity through a different perspective.http://dx.doi.org/10.1155/2020/6090262 |
| spellingShingle | Huihui Wang Shanshan Li Xi Chen Yanling Wang Jing Li Zhenchang Wang Cerebral Blood Flow Alterations in High Myopia: An Arterial Spin Labeling Study Neural Plasticity |
| title | Cerebral Blood Flow Alterations in High Myopia: An Arterial Spin Labeling Study |
| title_full | Cerebral Blood Flow Alterations in High Myopia: An Arterial Spin Labeling Study |
| title_fullStr | Cerebral Blood Flow Alterations in High Myopia: An Arterial Spin Labeling Study |
| title_full_unstemmed | Cerebral Blood Flow Alterations in High Myopia: An Arterial Spin Labeling Study |
| title_short | Cerebral Blood Flow Alterations in High Myopia: An Arterial Spin Labeling Study |
| title_sort | cerebral blood flow alterations in high myopia an arterial spin labeling study |
| url | http://dx.doi.org/10.1155/2020/6090262 |
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