Synthetic data as external control arms in scarce single-arm clinical trials.
An external control arm based on health registry data can serve as an alternative comparator in single-arm drug development studies that lack a benchmark for comparison to the experimental treatment. However, accessing such observational healthcare data involves a lengthy and intricate application p...
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Main Authors: | Severin Elvatun, Daan Knoors, Simon Brant, Christian Jonasson, Jan F Nygård |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2025-01-01
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Series: | PLOS Digital Health |
Online Access: | https://doi.org/10.1371/journal.pdig.0000581 |
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