Case report: A case report and literature review on the efficacy of high-dose aumolertinib combined intrathecal pemetrexed by Ommaya reservoir for EGFR-mutated NSCLC with leptomeningeal metastasis as the initial symptoms

Case report: A case report and literature review on the efficacy of high-dose aumolertinib combined intrathecal pemetrexed by Ommaya reservoir for EGFR-mutated NSCLC with leptomeningeal metastasis as the initial symptoms

Leptomeningeal metastasis (LM) is a significant complication of advanced non-small cell lung cancer (NSCLC), occurring in only 3-5% of patients and exceedingly rare in newly diagnosed NSCLC patients. This also indicates that the tumor is highly malignant and aggressive, which brings great challenges...

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Bibliographic Details
Main Authors: Maoxi Zhong, Li Zhou, Jing Guo, Chuan Chen, Wei Wang, Xiaoping Huang, Yi Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Oncology
Subjects:
high-dose aumolertinib
intrathecal chemotherapy
leptomeningeal metastasis
NSCLC
case report
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1502934/full
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