The transcription factor HMGB2 indirectly regulates APRIL expression and Gd-IgA1 production in patients with IgA nephropathy

The transcription factor HMGB2 indirectly regulates APRIL expression and Gd-IgA1 production in patients with IgA nephropathy

Background IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. Proliferation-inducing ligand (APRIL) was identified as an important cause of glycosylation deficiency of IgA1 (Gd-IgA1), which can ‘trigger’ IgAN. Our previous study indicated that high migration group protei...

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Bibliographic Details
Main Authors: Huijuan Tian, Yaling Zhai, Shuaigang Sun, Wenhui Zhang, Zhanzheng Zhao
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Renal Failure
Subjects:
IgA nephropathy
glycosylation-deficiency IgA1
high migration group protein B2
high migration group protein A1
proliferation-inducing ligand
Online Access:https://www.tandfonline.com/doi/10.1080/0886022X.2024.2338931
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