Protein S-palmitoylation regulates the virulence of plant pathogenic fungi
ABSTRACT Protein S-palmitoylation, a universal posttranslational modification catalyzed by a specific group of palmitoyltransferases, plays crucial roles in diverse biological processes across organisms by modulating protein functions. However, its roles in the virulence of plant pathogenic fungi re...
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| Language: | English |
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American Society for Microbiology
2025-02-01
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| Series: | mBio |
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| Online Access: | https://journals.asm.org/doi/10.1128/mbio.03472-24 |
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| _version_ | 1832096522146152448 |
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| author | Mengmeng Guo Leeza Tariq Fengming Song |
| author_facet | Mengmeng Guo Leeza Tariq Fengming Song |
| author_sort | Mengmeng Guo |
| collection | DOAJ |
| description | ABSTRACT Protein S-palmitoylation, a universal posttranslational modification catalyzed by a specific group of palmitoyltransferases, plays crucial roles in diverse biological processes across organisms by modulating protein functions. However, its roles in the virulence of plant pathogenic fungi remain underexplored. In a recent study, Y. Duan, P. Li, D. Zhang, L. Wang, et al. (mBio 15:e02704-24, 2024, https://doi.org/10.1128/mbio.02704-24) reported that the palmitoyltransferases UvPfa3 and UvPfa4 regulate the virulence of the rice false smut pathogen Ustilaginoidea virens. Through comprehensive characterization of S-palmitoylation sites, they revealed that S-palmitoylated proteins in U. virens are enriched in mitogen-activated protein (MAP) kinase and autophagy pathways, with MAP kinase UvSlt2 being a key target of UvPfa4-mediated S-palmitoylation. Further investigation demonstrated that S-palmitoylation of UvSlt2 is critical for its kinase activity, substrate interaction ability, and virulence function in U. virens. These findings reveal UvPfa4-mediated S-palmitoylation as a vital regulatory mechanism in U. virens virulence, highlighting the importance of protein S-palmitoylation in the pathogenicity of plant pathogenic fungi. |
| format | Article |
| id | doaj-art-7bf39acf038a4ba9927d7470cedd833b |
| institution | Kabale University |
| issn | 2150-7511 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mBio |
| spelling | doaj-art-7bf39acf038a4ba9927d7470cedd833b2025-02-05T14:00:48ZengAmerican Society for MicrobiologymBio2150-75112025-02-0116210.1128/mbio.03472-24Protein S-palmitoylation regulates the virulence of plant pathogenic fungiMengmeng Guo0Leeza Tariq1Fengming Song2Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insect Pests, Institute of Biotechnology, Zhejiang University, Hangzhou, ChinaMinistry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insect Pests, Institute of Biotechnology, Zhejiang University, Hangzhou, ChinaMinistry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insect Pests, Institute of Biotechnology, Zhejiang University, Hangzhou, ChinaABSTRACT Protein S-palmitoylation, a universal posttranslational modification catalyzed by a specific group of palmitoyltransferases, plays crucial roles in diverse biological processes across organisms by modulating protein functions. However, its roles in the virulence of plant pathogenic fungi remain underexplored. In a recent study, Y. Duan, P. Li, D. Zhang, L. Wang, et al. (mBio 15:e02704-24, 2024, https://doi.org/10.1128/mbio.02704-24) reported that the palmitoyltransferases UvPfa3 and UvPfa4 regulate the virulence of the rice false smut pathogen Ustilaginoidea virens. Through comprehensive characterization of S-palmitoylation sites, they revealed that S-palmitoylated proteins in U. virens are enriched in mitogen-activated protein (MAP) kinase and autophagy pathways, with MAP kinase UvSlt2 being a key target of UvPfa4-mediated S-palmitoylation. Further investigation demonstrated that S-palmitoylation of UvSlt2 is critical for its kinase activity, substrate interaction ability, and virulence function in U. virens. These findings reveal UvPfa4-mediated S-palmitoylation as a vital regulatory mechanism in U. virens virulence, highlighting the importance of protein S-palmitoylation in the pathogenicity of plant pathogenic fungi.https://journals.asm.org/doi/10.1128/mbio.03472-24palmitoyltransferaseS-palmitoylationUstilaginoidea virensvirulence |
| spellingShingle | Mengmeng Guo Leeza Tariq Fengming Song Protein S-palmitoylation regulates the virulence of plant pathogenic fungi mBio palmitoyltransferase S-palmitoylation Ustilaginoidea virens virulence |
| title | Protein S-palmitoylation regulates the virulence of plant pathogenic fungi |
| title_full | Protein S-palmitoylation regulates the virulence of plant pathogenic fungi |
| title_fullStr | Protein S-palmitoylation regulates the virulence of plant pathogenic fungi |
| title_full_unstemmed | Protein S-palmitoylation regulates the virulence of plant pathogenic fungi |
| title_short | Protein S-palmitoylation regulates the virulence of plant pathogenic fungi |
| title_sort | protein s palmitoylation regulates the virulence of plant pathogenic fungi |
| topic | palmitoyltransferase S-palmitoylation Ustilaginoidea virens virulence |
| url | https://journals.asm.org/doi/10.1128/mbio.03472-24 |
| work_keys_str_mv | AT mengmengguo proteinspalmitoylationregulatesthevirulenceofplantpathogenicfungi AT leezatariq proteinspalmitoylationregulatesthevirulenceofplantpathogenicfungi AT fengmingsong proteinspalmitoylationregulatesthevirulenceofplantpathogenicfungi |