Transcriptomic profiling of lncRNAs and mRNAs in a venous thrombosis mouse model
Summary: This study explores the role of lncRNAs and mRNAs in venous thromboembolism (VTE) using an inferior vena cava (IVC) mouse model. RNA sequencing identified differentially expressed lncRNAs and mRNAs between model and control groups. Enrichment analyses revealed significant pathways, includin...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004224027883 |
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| author | Risheng Hao Haobo Li Xincheng Li Jixiang Liu Xiaofan Ji Hong Zhang Zhu Zhang Peiran Yang Zhenguo Zhai |
| author_facet | Risheng Hao Haobo Li Xincheng Li Jixiang Liu Xiaofan Ji Hong Zhang Zhu Zhang Peiran Yang Zhenguo Zhai |
| author_sort | Risheng Hao |
| collection | DOAJ |
| description | Summary: This study explores the role of lncRNAs and mRNAs in venous thromboembolism (VTE) using an inferior vena cava (IVC) mouse model. RNA sequencing identified differentially expressed lncRNAs and mRNAs between model and control groups. Enrichment analyses revealed significant pathways, including HIF-1α signaling, glycolysis/gluconeogenesis, and platelet activation. A lncRNA-miRNA-mRNA network highlighted key regulatory interactions. Validation using qRT-PCR confirmed the RNA-seq findings. These results provide insights into the molecular mechanisms of VTE and suggest potential biomarkers and therapeutic targets for thrombosis. |
| format | Article |
| id | doaj-art-7bdb14811b104fa48f5b74da01f453c8 |
| institution | Kabale University |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-7bdb14811b104fa48f5b74da01f453c82025-01-31T05:12:11ZengElsevieriScience2589-00422025-02-01282111561Transcriptomic profiling of lncRNAs and mRNAs in a venous thrombosis mouse modelRisheng Hao0Haobo Li1Xincheng Li2Jixiang Liu3Xiaofan Ji4Hong Zhang5Zhu Zhang6Peiran Yang7Zhenguo Zhai8National Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China; Graduate School of Capital Medical University, Beijing, ChinaNational Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China; China-Japan Friendship Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, ChinaNational Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China; Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, ChinaNational Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, ChinaNational Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China; China-Japan Friendship Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, ChinaState Key Laboratory of Respiratory Health and Multimorbidity, Department of Physiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, ChinaNational Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China; Corresponding authorState Key Laboratory of Respiratory Health and Multimorbidity, Department of Physiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China; Corresponding authorNational Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China; Corresponding authorSummary: This study explores the role of lncRNAs and mRNAs in venous thromboembolism (VTE) using an inferior vena cava (IVC) mouse model. RNA sequencing identified differentially expressed lncRNAs and mRNAs between model and control groups. Enrichment analyses revealed significant pathways, including HIF-1α signaling, glycolysis/gluconeogenesis, and platelet activation. A lncRNA-miRNA-mRNA network highlighted key regulatory interactions. Validation using qRT-PCR confirmed the RNA-seq findings. These results provide insights into the molecular mechanisms of VTE and suggest potential biomarkers and therapeutic targets for thrombosis.http://www.sciencedirect.com/science/article/pii/S2589004224027883Cardiovascular medicineGenetics |
| spellingShingle | Risheng Hao Haobo Li Xincheng Li Jixiang Liu Xiaofan Ji Hong Zhang Zhu Zhang Peiran Yang Zhenguo Zhai Transcriptomic profiling of lncRNAs and mRNAs in a venous thrombosis mouse model iScience Cardiovascular medicine Genetics |
| title | Transcriptomic profiling of lncRNAs and mRNAs in a venous thrombosis mouse model |
| title_full | Transcriptomic profiling of lncRNAs and mRNAs in a venous thrombosis mouse model |
| title_fullStr | Transcriptomic profiling of lncRNAs and mRNAs in a venous thrombosis mouse model |
| title_full_unstemmed | Transcriptomic profiling of lncRNAs and mRNAs in a venous thrombosis mouse model |
| title_short | Transcriptomic profiling of lncRNAs and mRNAs in a venous thrombosis mouse model |
| title_sort | transcriptomic profiling of lncrnas and mrnas in a venous thrombosis mouse model |
| topic | Cardiovascular medicine Genetics |
| url | http://www.sciencedirect.com/science/article/pii/S2589004224027883 |
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