Coarctation of the aorta and accelerated atherosclerosis: A contemporary review on the burden of atherosclerotic cardiovascular disease
Coarctation of the aorta (CoA) is one of the most common types of congenital heart disease. Unfortunately, there is a high prevalence of hypertension and late cardiovascular mortality in patients with CoA despite successful repair. The growing impact of acquired cardiovascular disease remains a sign...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | International Journal of Cardiology Congenital Heart Disease |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666668524000703 |
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| author | Melissa G.Y. Lee Phillip S. Naimo Anoop N. Koshy Edward Buratto William M. Wilson Leeanne E. Grigg Subodh B. Joshi Katherine M. English |
| author_facet | Melissa G.Y. Lee Phillip S. Naimo Anoop N. Koshy Edward Buratto William M. Wilson Leeanne E. Grigg Subodh B. Joshi Katherine M. English |
| author_sort | Melissa G.Y. Lee |
| collection | DOAJ |
| description | Coarctation of the aorta (CoA) is one of the most common types of congenital heart disease. Unfortunately, there is a high prevalence of hypertension and late cardiovascular mortality in patients with CoA despite successful repair. The growing impact of acquired cardiovascular disease remains a significant concern as the adult congenital heart disease population continues to rapidly expand and age. This review aims to explore (1) the determinants of vascular health and atherosclerosis including endothelial dysfunction and vascular wall abnormalities, (2) the prevalence of atherosclerosis and associated sequelae in repaired CoA including coronary artery disease, coronary artery calcium, aortic calcium, stroke, and peripheral artery disease, and (3) the contributing factors specific to CoA. This review aims to guide optimization of long-term cardiovascular health to ultimately reduce mortality and morbidity in this young high-risk population. |
| format | Article |
| id | doaj-art-7bd2e1fbf22149959cd86d77fdc62b64 |
| institution | DOAJ |
| issn | 2666-6685 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology Congenital Heart Disease |
| spelling | doaj-art-7bd2e1fbf22149959cd86d77fdc62b642025-08-20T02:58:30ZengElsevierInternational Journal of Cardiology Congenital Heart Disease2666-66852025-03-011910056110.1016/j.ijcchd.2024.100561Coarctation of the aorta and accelerated atherosclerosis: A contemporary review on the burden of atherosclerotic cardiovascular diseaseMelissa G.Y. Lee0Phillip S. Naimo1Anoop N. Koshy2Edward Buratto3William M. Wilson4Leeanne E. Grigg5Subodh B. Joshi6Katherine M. English7Department of Cardiology, The Royal Melbourne Hospital, Melbourne, Australia; Department of Medicine, The Royal Melbourne Hospital, University of Melbourne, Melbourne, Australia; Heart Research Group, Murdoch Children's Research Institute, Melbourne, Australia; Department of Paediatrics, University of Melbourne, Melbourne, Australia; Corresponding author. Department of Cardiology, The Royal Melbourne Hospital, 300 Grattan St, Parkville, VIC. 3050, Australia.Department of Cardiology, The Royal Melbourne Hospital, Melbourne, Australia; Department of Medicine, The Royal Melbourne Hospital, University of Melbourne, Melbourne, Australia; Department of Paediatrics, University of Melbourne, Melbourne, AustraliaDepartment of Cardiology, The Royal Melbourne Hospital, Melbourne, Australia; Department of Medicine, The Royal Melbourne Hospital, University of Melbourne, Melbourne, Australia; Department of Medicine, Austin Health, University of Melbourne, Melbourne, Australia; Department of Cardiology, Austin Health, Melbourne, AustraliaHeart Research Group, Murdoch Children's Research Institute, Melbourne, Australia; Department of Paediatrics, University of Melbourne, Melbourne, Australia; Department of Cardiothoracic Surgery, The Royal Melbourne Hospital, Melbourne, Australia; Department of Cardiac Surgery, The Royal Children's Hospital, Melbourne, AustraliaDepartment of Cardiology, The Royal Melbourne Hospital, Melbourne, Australia; Department of Medicine, The Royal Melbourne Hospital, University of Melbourne, Melbourne, AustraliaDepartment of Cardiology, The Royal Melbourne Hospital, Melbourne, Australia; Department of Medicine, The Royal Melbourne Hospital, University of Melbourne, Melbourne, AustraliaDepartment of Cardiology, The Royal Melbourne Hospital, Melbourne, Australia; Department of Medicine, The Royal Melbourne Hospital, University of Melbourne, Melbourne, AustraliaDepartment of Cardiology, The Royal Melbourne Hospital, Melbourne, AustraliaCoarctation of the aorta (CoA) is one of the most common types of congenital heart disease. Unfortunately, there is a high prevalence of hypertension and late cardiovascular mortality in patients with CoA despite successful repair. The growing impact of acquired cardiovascular disease remains a significant concern as the adult congenital heart disease population continues to rapidly expand and age. This review aims to explore (1) the determinants of vascular health and atherosclerosis including endothelial dysfunction and vascular wall abnormalities, (2) the prevalence of atherosclerosis and associated sequelae in repaired CoA including coronary artery disease, coronary artery calcium, aortic calcium, stroke, and peripheral artery disease, and (3) the contributing factors specific to CoA. This review aims to guide optimization of long-term cardiovascular health to ultimately reduce mortality and morbidity in this young high-risk population.http://www.sciencedirect.com/science/article/pii/S2666668524000703Arterial stiffnessAtherosclerosisCoarctation of the aortaCoronary artery calciumCoronary artery diseaseEndothelial dysfunction |
| spellingShingle | Melissa G.Y. Lee Phillip S. Naimo Anoop N. Koshy Edward Buratto William M. Wilson Leeanne E. Grigg Subodh B. Joshi Katherine M. English Coarctation of the aorta and accelerated atherosclerosis: A contemporary review on the burden of atherosclerotic cardiovascular disease International Journal of Cardiology Congenital Heart Disease Arterial stiffness Atherosclerosis Coarctation of the aorta Coronary artery calcium Coronary artery disease Endothelial dysfunction |
| title | Coarctation of the aorta and accelerated atherosclerosis: A contemporary review on the burden of atherosclerotic cardiovascular disease |
| title_full | Coarctation of the aorta and accelerated atherosclerosis: A contemporary review on the burden of atherosclerotic cardiovascular disease |
| title_fullStr | Coarctation of the aorta and accelerated atherosclerosis: A contemporary review on the burden of atherosclerotic cardiovascular disease |
| title_full_unstemmed | Coarctation of the aorta and accelerated atherosclerosis: A contemporary review on the burden of atherosclerotic cardiovascular disease |
| title_short | Coarctation of the aorta and accelerated atherosclerosis: A contemporary review on the burden of atherosclerotic cardiovascular disease |
| title_sort | coarctation of the aorta and accelerated atherosclerosis a contemporary review on the burden of atherosclerotic cardiovascular disease |
| topic | Arterial stiffness Atherosclerosis Coarctation of the aorta Coronary artery calcium Coronary artery disease Endothelial dysfunction |
| url | http://www.sciencedirect.com/science/article/pii/S2666668524000703 |
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