Multiple Transverse Colonic Perforations Associated with Slow-Release Nonsteroidal Anti-Inflammatory Drugs and Corticosteroids: A Case Report
The patient was a 36-year-old woman with sarcoidosis and Sjogren's syndrome, and had been prescribed slow-release diclofenac sodium and prednisolone for the treatment of pain associated with uveitis and erythema nodosum. She was admitted to our emergency center with abdominal pain and distentio...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
|
| Series: | Case Reports in Critical Care |
| Online Access: | http://dx.doi.org/10.1155/2011/824639 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832545651970277376 |
|---|---|
| author | Nobuki Shioya Shigehiro Shibata Masahiro Kojika Shigeatsu Endo |
| author_facet | Nobuki Shioya Shigehiro Shibata Masahiro Kojika Shigeatsu Endo |
| author_sort | Nobuki Shioya |
| collection | DOAJ |
| description | The patient was a 36-year-old woman with sarcoidosis and Sjogren's syndrome, and had been prescribed slow-release diclofenac sodium and prednisolone for the treatment of pain associated with uveitis and erythema nodosum. She was admitted to our emergency center with abdominal pain and distention. A chest X-ray showed free air under the diaphragm on both sides, and an emergency laparotomy was performed for suspected panperitonitis associated with intestinal perforation. Laparotomy revealed several perforations on the antimesenteric aspect of the transverse colon. The resected specimen showed 11 punched-out ulcerations, many of which were up to 10 mm in diameter. The microscopic findings were non-specific, with leukocytic infiltration around the perforations. She showed good postoperative recovery, as evaluated on day 42. The present case highlights the need for exercising caution while prescribing slow-release nonsteroidal anti-inflammatory drugs with corticosteroids to patients with autoimmune diseases, as such treatment may exacerbate intestinal epithelial abnormalities. |
| format | Article |
| id | doaj-art-7bc6423916e342cbbd477f2a5481ef7d |
| institution | Kabale University |
| issn | 2090-6420 2090-6439 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Critical Care |
| spelling | doaj-art-7bc6423916e342cbbd477f2a5481ef7d2025-02-03T07:25:10ZengWileyCase Reports in Critical Care2090-64202090-64392011-01-01201110.1155/2011/824639824639Multiple Transverse Colonic Perforations Associated with Slow-Release Nonsteroidal Anti-Inflammatory Drugs and Corticosteroids: A Case ReportNobuki Shioya0Shigehiro Shibata1Masahiro Kojika2Shigeatsu Endo3Department of Critical Care and Emergency, Iwate Prefectural Advanced Critical Care and Emergency Center, Iwate Medical University, 19-1 Uchimaru, Morioka 020-8505, JapanDepartment of Critical Care and Emergency, Iwate Prefectural Advanced Critical Care and Emergency Center, Iwate Medical University, 19-1 Uchimaru, Morioka 020-8505, JapanDepartment of Critical Care and Emergency, Iwate Prefectural Advanced Critical Care and Emergency Center, Iwate Medical University, 19-1 Uchimaru, Morioka 020-8505, JapanDepartment of Critical Care and Emergency, Iwate Prefectural Advanced Critical Care and Emergency Center, Iwate Medical University, 19-1 Uchimaru, Morioka 020-8505, JapanThe patient was a 36-year-old woman with sarcoidosis and Sjogren's syndrome, and had been prescribed slow-release diclofenac sodium and prednisolone for the treatment of pain associated with uveitis and erythema nodosum. She was admitted to our emergency center with abdominal pain and distention. A chest X-ray showed free air under the diaphragm on both sides, and an emergency laparotomy was performed for suspected panperitonitis associated with intestinal perforation. Laparotomy revealed several perforations on the antimesenteric aspect of the transverse colon. The resected specimen showed 11 punched-out ulcerations, many of which were up to 10 mm in diameter. The microscopic findings were non-specific, with leukocytic infiltration around the perforations. She showed good postoperative recovery, as evaluated on day 42. The present case highlights the need for exercising caution while prescribing slow-release nonsteroidal anti-inflammatory drugs with corticosteroids to patients with autoimmune diseases, as such treatment may exacerbate intestinal epithelial abnormalities.http://dx.doi.org/10.1155/2011/824639 |
| spellingShingle | Nobuki Shioya Shigehiro Shibata Masahiro Kojika Shigeatsu Endo Multiple Transverse Colonic Perforations Associated with Slow-Release Nonsteroidal Anti-Inflammatory Drugs and Corticosteroids: A Case Report Case Reports in Critical Care |
| title | Multiple Transverse Colonic Perforations Associated with Slow-Release Nonsteroidal Anti-Inflammatory Drugs and Corticosteroids: A Case Report |
| title_full | Multiple Transverse Colonic Perforations Associated with Slow-Release Nonsteroidal Anti-Inflammatory Drugs and Corticosteroids: A Case Report |
| title_fullStr | Multiple Transverse Colonic Perforations Associated with Slow-Release Nonsteroidal Anti-Inflammatory Drugs and Corticosteroids: A Case Report |
| title_full_unstemmed | Multiple Transverse Colonic Perforations Associated with Slow-Release Nonsteroidal Anti-Inflammatory Drugs and Corticosteroids: A Case Report |
| title_short | Multiple Transverse Colonic Perforations Associated with Slow-Release Nonsteroidal Anti-Inflammatory Drugs and Corticosteroids: A Case Report |
| title_sort | multiple transverse colonic perforations associated with slow release nonsteroidal anti inflammatory drugs and corticosteroids a case report |
| url | http://dx.doi.org/10.1155/2011/824639 |
| work_keys_str_mv | AT nobukishioya multipletransversecolonicperforationsassociatedwithslowreleasenonsteroidalantiinflammatorydrugsandcorticosteroidsacasereport AT shigehiroshibata multipletransversecolonicperforationsassociatedwithslowreleasenonsteroidalantiinflammatorydrugsandcorticosteroidsacasereport AT masahirokojika multipletransversecolonicperforationsassociatedwithslowreleasenonsteroidalantiinflammatorydrugsandcorticosteroidsacasereport AT shigeatsuendo multipletransversecolonicperforationsassociatedwithslowreleasenonsteroidalantiinflammatorydrugsandcorticosteroidsacasereport |