Multi-level encoding of reward, effort, and choice across the frontal cortex and basal ganglia during cost-benefit decision-making
Summary: Adaptive value-guided decision-making requires weighing up the costs and benefits of pursuing an available opportunity. Though neurons across frontal cortical-basal ganglia circuits have been repeatedly shown to represent decision-related parameters, it is unclear whether and how this infor...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Cell Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124724015602 |
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| author | Oliver Härmson Isaac Grennan Brook Perry Robert Toth Colin G. McNamara Timothy Denison Hayriye Cagnan Sanjay G. Manohar Mark E. Walton Andrew Sharott |
| author_facet | Oliver Härmson Isaac Grennan Brook Perry Robert Toth Colin G. McNamara Timothy Denison Hayriye Cagnan Sanjay G. Manohar Mark E. Walton Andrew Sharott |
| author_sort | Oliver Härmson |
| collection | DOAJ |
| description | Summary: Adaptive value-guided decision-making requires weighing up the costs and benefits of pursuing an available opportunity. Though neurons across frontal cortical-basal ganglia circuits have been repeatedly shown to represent decision-related parameters, it is unclear whether and how this information is coordinated. To address this question, we performed large-scale single-unit recordings simultaneously across 5 medial/orbital frontal and basal ganglia regions as rats decided whether to pursue varying reward payoffs available at different effort costs. Single neurons encoding combinations of decision variables (reward, effort, and choice) were represented within all recorded regions. Coactive cell assemblies, ensembles of neurons that repeatedly coactivated within short time windows (<25 ms), represented the same decision variables despite the members often having diverse individual coding properties. Together, these findings demonstrate a multi-level encoding structure for cost-benefit computations where individual neurons are coordinated into larger assemblies that can represent task variables independently of their constituent components. |
| format | Article |
| id | doaj-art-7bac669af03947a4ba620e9e12948649 |
| institution | Kabale University |
| issn | 2211-1247 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj-art-7bac669af03947a4ba620e9e129486492025-01-24T04:44:58ZengElsevierCell Reports2211-12472025-02-01442115209Multi-level encoding of reward, effort, and choice across the frontal cortex and basal ganglia during cost-benefit decision-makingOliver Härmson0Isaac Grennan1Brook Perry2Robert Toth3Colin G. McNamara4Timothy Denison5Hayriye Cagnan6Sanjay G. Manohar7Mark E. Walton8Andrew Sharott9Medical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK; Department of Experimental Psychology, University of Oxford, Oxford, UK; Corresponding authorMedical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UKMedical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UKMedical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UKMedical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UKMedical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK; Department of Engineering Science, University of Oxford, Oxford, UKMedical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UKDepartment of Experimental Psychology, University of Oxford, Oxford, UK; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UKDepartment of Experimental Psychology, University of Oxford, Oxford, UK; Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, UKMedical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK; Corresponding authorSummary: Adaptive value-guided decision-making requires weighing up the costs and benefits of pursuing an available opportunity. Though neurons across frontal cortical-basal ganglia circuits have been repeatedly shown to represent decision-related parameters, it is unclear whether and how this information is coordinated. To address this question, we performed large-scale single-unit recordings simultaneously across 5 medial/orbital frontal and basal ganglia regions as rats decided whether to pursue varying reward payoffs available at different effort costs. Single neurons encoding combinations of decision variables (reward, effort, and choice) were represented within all recorded regions. Coactive cell assemblies, ensembles of neurons that repeatedly coactivated within short time windows (<25 ms), represented the same decision variables despite the members often having diverse individual coding properties. Together, these findings demonstrate a multi-level encoding structure for cost-benefit computations where individual neurons are coordinated into larger assemblies that can represent task variables independently of their constituent components.http://www.sciencedirect.com/science/article/pii/S2211124724015602CP: Neuroscience |
| spellingShingle | Oliver Härmson Isaac Grennan Brook Perry Robert Toth Colin G. McNamara Timothy Denison Hayriye Cagnan Sanjay G. Manohar Mark E. Walton Andrew Sharott Multi-level encoding of reward, effort, and choice across the frontal cortex and basal ganglia during cost-benefit decision-making Cell Reports CP: Neuroscience |
| title | Multi-level encoding of reward, effort, and choice across the frontal cortex and basal ganglia during cost-benefit decision-making |
| title_full | Multi-level encoding of reward, effort, and choice across the frontal cortex and basal ganglia during cost-benefit decision-making |
| title_fullStr | Multi-level encoding of reward, effort, and choice across the frontal cortex and basal ganglia during cost-benefit decision-making |
| title_full_unstemmed | Multi-level encoding of reward, effort, and choice across the frontal cortex and basal ganglia during cost-benefit decision-making |
| title_short | Multi-level encoding of reward, effort, and choice across the frontal cortex and basal ganglia during cost-benefit decision-making |
| title_sort | multi level encoding of reward effort and choice across the frontal cortex and basal ganglia during cost benefit decision making |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124724015602 |
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