Defining the role of the MHC in autoimmunity: a review and pooled analysis.
The major histocompatibility complex (MHC) is one of the most extensively studied regions in the human genome because of the association of variants at this locus with autoimmune, infectious, and inflammatory diseases. However, identification of causal variants within the MHC for the majority of the...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2008-04-01
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| Series: | PLoS Genetics |
| Online Access: | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000024&type=printable |
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| author | Michelle M A Fernando Christine R Stevens Emily C Walsh Philip L De Jager Philippe Goyette Robert M Plenge Timothy J Vyse John D Rioux |
| author_facet | Michelle M A Fernando Christine R Stevens Emily C Walsh Philip L De Jager Philippe Goyette Robert M Plenge Timothy J Vyse John D Rioux |
| author_sort | Michelle M A Fernando |
| collection | DOAJ |
| description | The major histocompatibility complex (MHC) is one of the most extensively studied regions in the human genome because of the association of variants at this locus with autoimmune, infectious, and inflammatory diseases. However, identification of causal variants within the MHC for the majority of these diseases has remained difficult due to the great variability and extensive linkage disequilibrium (LD) that exists among alleles throughout this locus, coupled with inadequate study design whereby only a limited subset of about 20 from a total of approximately 250 genes have been studied in small cohorts of predominantly European origin. We have performed a review and pooled analysis of the past 30 years of research on the role of the MHC in six genetically complex disease traits - multiple sclerosis (MS), type 1 diabetes (T1D), systemic lupus erythematosus (SLE), ulcerative colitis (UC), Crohn's disease (CD), and rheumatoid arthritis (RA) - in order to consolidate and evaluate the current literature regarding MHC genetics in these common autoimmune and inflammatory diseases. We corroborate established MHC disease associations and identify predisposing variants that previously have not been appreciated. Furthermore, we find a number of interesting commonalities and differences across diseases that implicate both general and disease-specific pathogenetic mechanisms in autoimmunity. |
| format | Article |
| id | doaj-art-7ba9a0cf6da54566bc8498212da0a2ee |
| institution | DOAJ |
| issn | 1553-7390 1553-7404 |
| language | English |
| publishDate | 2008-04-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Genetics |
| spelling | doaj-art-7ba9a0cf6da54566bc8498212da0a2ee2025-08-20T03:22:38ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042008-04-0144e100002410.1371/journal.pgen.1000024Defining the role of the MHC in autoimmunity: a review and pooled analysis.Michelle M A FernandoChristine R StevensEmily C WalshPhilip L De JagerPhilippe GoyetteRobert M PlengeTimothy J VyseJohn D RiouxThe major histocompatibility complex (MHC) is one of the most extensively studied regions in the human genome because of the association of variants at this locus with autoimmune, infectious, and inflammatory diseases. However, identification of causal variants within the MHC for the majority of these diseases has remained difficult due to the great variability and extensive linkage disequilibrium (LD) that exists among alleles throughout this locus, coupled with inadequate study design whereby only a limited subset of about 20 from a total of approximately 250 genes have been studied in small cohorts of predominantly European origin. We have performed a review and pooled analysis of the past 30 years of research on the role of the MHC in six genetically complex disease traits - multiple sclerosis (MS), type 1 diabetes (T1D), systemic lupus erythematosus (SLE), ulcerative colitis (UC), Crohn's disease (CD), and rheumatoid arthritis (RA) - in order to consolidate and evaluate the current literature regarding MHC genetics in these common autoimmune and inflammatory diseases. We corroborate established MHC disease associations and identify predisposing variants that previously have not been appreciated. Furthermore, we find a number of interesting commonalities and differences across diseases that implicate both general and disease-specific pathogenetic mechanisms in autoimmunity.https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000024&type=printable |
| spellingShingle | Michelle M A Fernando Christine R Stevens Emily C Walsh Philip L De Jager Philippe Goyette Robert M Plenge Timothy J Vyse John D Rioux Defining the role of the MHC in autoimmunity: a review and pooled analysis. PLoS Genetics |
| title | Defining the role of the MHC in autoimmunity: a review and pooled analysis. |
| title_full | Defining the role of the MHC in autoimmunity: a review and pooled analysis. |
| title_fullStr | Defining the role of the MHC in autoimmunity: a review and pooled analysis. |
| title_full_unstemmed | Defining the role of the MHC in autoimmunity: a review and pooled analysis. |
| title_short | Defining the role of the MHC in autoimmunity: a review and pooled analysis. |
| title_sort | defining the role of the mhc in autoimmunity a review and pooled analysis |
| url | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000024&type=printable |
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