Oxidative Stress, Tumor Microenvironment, and Metabolic Reprogramming: A Diabolic Liaison
Conversely to normal cells, where deregulated oxidative stress drives the activation of death pathways, malignant cells exploit oxidative milieu for its advantage. Cancer cells are located in a very complex microenvironment together with stromal components that participate to enhance oxidative stres...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2012/762825 |
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| _version_ | 1832568007359987712 |
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| author | Tania Fiaschi Paola Chiarugi |
| author_facet | Tania Fiaschi Paola Chiarugi |
| author_sort | Tania Fiaschi |
| collection | DOAJ |
| description | Conversely to normal cells, where deregulated oxidative stress drives the activation of death pathways, malignant cells exploit oxidative milieu for its advantage. Cancer cells are located in a very complex microenvironment together with stromal components that participate to enhance oxidative stress to promote tumor progression. Indeed, convincing experimental and clinical evidence underline the key role of oxidative stress in several tumor aspects thus affecting several characteristics of cancer cells. Oxidants influence the DNA mutational potential, intracellular signaling pathways controlling cell proliferation and survival and cell motility and invasiveness as well as control the reactivity of stromal components that is fundamental for cancer development and dissemination, inflammation, tissue repair, and de novo angiogenesis. This paper is focused on the role of oxidant species in the acquisition of two mandatory features for aggressive neoplastic cells, recently defined by Hanahan and Weinberg as new “hallmarks of cancer”: tumor microenvironment and metabolic reprogramming of cancer cells. |
| format | Article |
| id | doaj-art-7ba51ab0bf8148679b8d691088cf4106 |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-7ba51ab0bf8148679b8d691088cf41062025-02-03T00:59:57ZengWileyInternational Journal of Cell Biology1687-88761687-88842012-01-01201210.1155/2012/762825762825Oxidative Stress, Tumor Microenvironment, and Metabolic Reprogramming: A Diabolic LiaisonTania Fiaschi0Paola Chiarugi1Department of Biochemical Sciences, University of Florence, 50134 Florence, ItalyDepartment of Biochemical Sciences, University of Florence, 50134 Florence, ItalyConversely to normal cells, where deregulated oxidative stress drives the activation of death pathways, malignant cells exploit oxidative milieu for its advantage. Cancer cells are located in a very complex microenvironment together with stromal components that participate to enhance oxidative stress to promote tumor progression. Indeed, convincing experimental and clinical evidence underline the key role of oxidative stress in several tumor aspects thus affecting several characteristics of cancer cells. Oxidants influence the DNA mutational potential, intracellular signaling pathways controlling cell proliferation and survival and cell motility and invasiveness as well as control the reactivity of stromal components that is fundamental for cancer development and dissemination, inflammation, tissue repair, and de novo angiogenesis. This paper is focused on the role of oxidant species in the acquisition of two mandatory features for aggressive neoplastic cells, recently defined by Hanahan and Weinberg as new “hallmarks of cancer”: tumor microenvironment and metabolic reprogramming of cancer cells.http://dx.doi.org/10.1155/2012/762825 |
| spellingShingle | Tania Fiaschi Paola Chiarugi Oxidative Stress, Tumor Microenvironment, and Metabolic Reprogramming: A Diabolic Liaison International Journal of Cell Biology |
| title | Oxidative Stress, Tumor Microenvironment, and Metabolic Reprogramming: A Diabolic Liaison |
| title_full | Oxidative Stress, Tumor Microenvironment, and Metabolic Reprogramming: A Diabolic Liaison |
| title_fullStr | Oxidative Stress, Tumor Microenvironment, and Metabolic Reprogramming: A Diabolic Liaison |
| title_full_unstemmed | Oxidative Stress, Tumor Microenvironment, and Metabolic Reprogramming: A Diabolic Liaison |
| title_short | Oxidative Stress, Tumor Microenvironment, and Metabolic Reprogramming: A Diabolic Liaison |
| title_sort | oxidative stress tumor microenvironment and metabolic reprogramming a diabolic liaison |
| url | http://dx.doi.org/10.1155/2012/762825 |
| work_keys_str_mv | AT taniafiaschi oxidativestresstumormicroenvironmentandmetabolicreprogrammingadiabolicliaison AT paolachiarugi oxidativestresstumormicroenvironmentandmetabolicreprogrammingadiabolicliaison |