Malignant Phyllodes Tumor and Acute Megakaryoblastic Leukemia Sharing a Common Clonal Origin
There is a well-known association in male patients between mediastinal germ cell tumors (GCT) and hematologic malignancies, with a propensity towards acute megakaryoblastic leukemia. These rare malignancies have been shown to share a common clonal origin, often deduced from the finding of isochromos...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2013/934781 |
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| author | Yngvar Fløisand Klaus Beiske Geir Erland Tjønnfjord Dag Heldal Bodil Bjerkehagen Mona-Elisabeth Revheim Sverre Heim Øyvind Sverre Bruland Kirsten Sundby Hall Anne Tierens Jan Delabie |
| author_facet | Yngvar Fløisand Klaus Beiske Geir Erland Tjønnfjord Dag Heldal Bodil Bjerkehagen Mona-Elisabeth Revheim Sverre Heim Øyvind Sverre Bruland Kirsten Sundby Hall Anne Tierens Jan Delabie |
| author_sort | Yngvar Fløisand |
| collection | DOAJ |
| description | There is a well-known association in male patients between mediastinal germ cell tumors (GCT) and hematologic malignancies, with a propensity towards acute megakaryoblastic leukemia. These rare malignancies have been shown to share a common clonal origin, often deduced from the finding of isochromosome 12p, i(12p), in cells from both the solid tumor and the leukemia, and thus are now known to represent different manifestations of the same clonal process. We treated a young female patient with a malignant phyllodes tumor followed by an acute megakaryoblastic leukemia and found several of the same marker chromosomes by karyotype analysis of cells from both the tumor and the leukemia implying a common clonal origin of the two. To the best of our knowledge, this has not been demonstrated in phyllodes tumors before, but indicates that the same type of leukemization may occur of this tumor as has been described in mediastinal GCT. |
| format | Article |
| id | doaj-art-7ba48aabb55f4cc484cd3d29e3f7146e |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-7ba48aabb55f4cc484cd3d29e3f7146e2025-02-03T06:00:46ZengWileyCase Reports in Hematology2090-65602090-65792013-01-01201310.1155/2013/934781934781Malignant Phyllodes Tumor and Acute Megakaryoblastic Leukemia Sharing a Common Clonal OriginYngvar Fløisand0Klaus Beiske1Geir Erland Tjønnfjord2Dag Heldal3Bodil Bjerkehagen4Mona-Elisabeth Revheim5Sverre Heim6Øyvind Sverre Bruland7Kirsten Sundby Hall8Anne Tierens9Jan Delabie10Department of Hematology, University of Oslo, P.O. Box 4950, Nydalen, 0424 Oslo, NorwayDepartment of Pathology, University of Oslo, P.O. Box 4950, Nydalen, 0424 Oslo, NorwayDepartment of Hematology, University of Oslo, P.O. Box 4950, Nydalen, 0424 Oslo, NorwayDepartment of Hematology, University of Oslo, P.O. Box 4950, Nydalen, 0424 Oslo, NorwayDepartment of Pathology, University of Oslo, P.O. Box 4950, Nydalen, 0424 Oslo, NorwayDepartment of Nuclear Medicine, Oslo University Hospital, University of Oslo, P.O. Box 4950, Nydalen, 0424 Oslo, NorwayInstitute of Clinical Medicine, University of Oslo, P.O. Box 4950, Nydalen, 0424 Oslo, NorwayInstitute of Clinical Medicine, University of Oslo, P.O. Box 4950, Nydalen, 0424 Oslo, NorwayDepartment of Oncology, University of Oslo, P.O. Box 4950, Nydalen, 0424 Oslo, NorwayDepartment of Pathology, University of Oslo, P.O. Box 4950, Nydalen, 0424 Oslo, NorwayDepartment of Pathology, University of Oslo, P.O. Box 4950, Nydalen, 0424 Oslo, NorwayThere is a well-known association in male patients between mediastinal germ cell tumors (GCT) and hematologic malignancies, with a propensity towards acute megakaryoblastic leukemia. These rare malignancies have been shown to share a common clonal origin, often deduced from the finding of isochromosome 12p, i(12p), in cells from both the solid tumor and the leukemia, and thus are now known to represent different manifestations of the same clonal process. We treated a young female patient with a malignant phyllodes tumor followed by an acute megakaryoblastic leukemia and found several of the same marker chromosomes by karyotype analysis of cells from both the tumor and the leukemia implying a common clonal origin of the two. To the best of our knowledge, this has not been demonstrated in phyllodes tumors before, but indicates that the same type of leukemization may occur of this tumor as has been described in mediastinal GCT.http://dx.doi.org/10.1155/2013/934781 |
| spellingShingle | Yngvar Fløisand Klaus Beiske Geir Erland Tjønnfjord Dag Heldal Bodil Bjerkehagen Mona-Elisabeth Revheim Sverre Heim Øyvind Sverre Bruland Kirsten Sundby Hall Anne Tierens Jan Delabie Malignant Phyllodes Tumor and Acute Megakaryoblastic Leukemia Sharing a Common Clonal Origin Case Reports in Hematology |
| title | Malignant Phyllodes Tumor and Acute Megakaryoblastic Leukemia Sharing a Common Clonal Origin |
| title_full | Malignant Phyllodes Tumor and Acute Megakaryoblastic Leukemia Sharing a Common Clonal Origin |
| title_fullStr | Malignant Phyllodes Tumor and Acute Megakaryoblastic Leukemia Sharing a Common Clonal Origin |
| title_full_unstemmed | Malignant Phyllodes Tumor and Acute Megakaryoblastic Leukemia Sharing a Common Clonal Origin |
| title_short | Malignant Phyllodes Tumor and Acute Megakaryoblastic Leukemia Sharing a Common Clonal Origin |
| title_sort | malignant phyllodes tumor and acute megakaryoblastic leukemia sharing a common clonal origin |
| url | http://dx.doi.org/10.1155/2013/934781 |
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