Potential Capsule Switching from Serogroup Y to B: The Characterization of Three such Neisseria meningitidis Isolates Causing Invasive Meningococcal Disease in Canada
Three group B Neisseria meningitidis isolates, recovered from meningococcal disease cases in Canada and typed as B:2c:P1.5, were characterized. Multilocus sequence typing showed that all three isolates were related because of an identical sequence type (ST) 573. Isolates typed as 2c:P1.5 are co...
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| Format: | Article |
| Language: | English |
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Wiley
2005-01-01
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| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2005/216369 |
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| _version_ | 1832567803275640832 |
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| author | Raymond SW Tsang Dennis KS Law Shaun D Tyler Gwen S Stephens Mark Bigham Wendell D Zollinger |
| author_facet | Raymond SW Tsang Dennis KS Law Shaun D Tyler Gwen S Stephens Mark Bigham Wendell D Zollinger |
| author_sort | Raymond SW Tsang |
| collection | DOAJ |
| description | Three group B Neisseria meningitidis isolates, recovered from meningococcal disease cases in Canada and typed as B:2c:P1.5, were characterized. Multilocus sequence typing showed that all three isolates were related because of an identical sequence type (ST) 573. Isolates typed as 2c:P1.5 are common in serogroup Y meningococci but rare in isolates from serogroups B or C. Although no serogroup Y isolates have been typed as ST-573, eight isolates showed five to six housekeeping gene alleles that were identical to that of ST-573. This suggested that the B:2c:P1.5 isolates may have originated from serogroup Y organisms, possibly by capsule switching. |
| format | Article |
| id | doaj-art-7ba4597817624aaaafcd40eb51183c47 |
| institution | Kabale University |
| issn | 1712-9532 |
| language | English |
| publishDate | 2005-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj-art-7ba4597817624aaaafcd40eb51183c472025-02-03T01:00:33ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1712-95322005-01-0116317117410.1155/2005/216369Potential Capsule Switching from Serogroup Y to B: The Characterization of Three such Neisseria meningitidis Isolates Causing Invasive Meningococcal Disease in CanadaRaymond SW Tsang0Dennis KS Law1Shaun D Tyler2Gwen S Stephens3Mark Bigham4Wendell D Zollinger5Laboratory for Pathogenic Neisseria and Vaccine Preventable Bacterial Diseases, Winnipeg, Manitoba, CanadaLaboratory for Pathogenic Neisseria and Vaccine Preventable Bacterial Diseases, Winnipeg, Manitoba, CanadaDNA Core Facility, National Microbiology Laboratory, Health Canada, Winnipeg, Manitoba, CanadaBritish Columbia Centre for Disease Control, British Columbia, CanadaBritish Columbia Centre for Disease Control, British Columbia, CanadaWalter Reed Army Institute of Research, Washington, District of Columbia, USAThree group B Neisseria meningitidis isolates, recovered from meningococcal disease cases in Canada and typed as B:2c:P1.5, were characterized. Multilocus sequence typing showed that all three isolates were related because of an identical sequence type (ST) 573. Isolates typed as 2c:P1.5 are common in serogroup Y meningococci but rare in isolates from serogroups B or C. Although no serogroup Y isolates have been typed as ST-573, eight isolates showed five to six housekeeping gene alleles that were identical to that of ST-573. This suggested that the B:2c:P1.5 isolates may have originated from serogroup Y organisms, possibly by capsule switching.http://dx.doi.org/10.1155/2005/216369 |
| spellingShingle | Raymond SW Tsang Dennis KS Law Shaun D Tyler Gwen S Stephens Mark Bigham Wendell D Zollinger Potential Capsule Switching from Serogroup Y to B: The Characterization of Three such Neisseria meningitidis Isolates Causing Invasive Meningococcal Disease in Canada Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | Potential Capsule Switching from Serogroup Y to B: The Characterization of Three such Neisseria meningitidis Isolates Causing Invasive Meningococcal Disease in Canada |
| title_full | Potential Capsule Switching from Serogroup Y to B: The Characterization of Three such Neisseria meningitidis Isolates Causing Invasive Meningococcal Disease in Canada |
| title_fullStr | Potential Capsule Switching from Serogroup Y to B: The Characterization of Three such Neisseria meningitidis Isolates Causing Invasive Meningococcal Disease in Canada |
| title_full_unstemmed | Potential Capsule Switching from Serogroup Y to B: The Characterization of Three such Neisseria meningitidis Isolates Causing Invasive Meningococcal Disease in Canada |
| title_short | Potential Capsule Switching from Serogroup Y to B: The Characterization of Three such Neisseria meningitidis Isolates Causing Invasive Meningococcal Disease in Canada |
| title_sort | potential capsule switching from serogroup y to b the characterization of three such neisseria meningitidis isolates causing invasive meningococcal disease in canada |
| url | http://dx.doi.org/10.1155/2005/216369 |
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