Looking for Pyroptosis-Modulating miRNAs as a Therapeutic Target for Improving Myocardium Survival
Pyroptosis is the most recently identified type of regulated cell death with inflammatory response and has characteristics distinct from those of apoptosis or necrosis. Recently, independent studies have reported that small noncoding RNAs termed microRNAs (miRNAs) are involved in the regulation of p...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/254871 |
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| _version_ | 1832551681024327680 |
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| author | Seahyoung Lee Eunhyun Choi Min-Ji Cha Ki-Chul Hwang |
| author_facet | Seahyoung Lee Eunhyun Choi Min-Ji Cha Ki-Chul Hwang |
| author_sort | Seahyoung Lee |
| collection | DOAJ |
| description | Pyroptosis is the most recently identified type of regulated cell death with inflammatory response and has characteristics distinct from those of apoptosis or necrosis. Recently, independent studies have reported that small noncoding RNAs termed microRNAs (miRNAs) are involved in the regulation of pyroptosis. Nevertheless, only a handful of empirical data regarding miRNA-dependent regulation of pyroptosis is currently available. This review is aimed to provide a current update on the role of miRNAs in pyroptosis and to offer suggestions for future studies probing miRNAs as a linker connecting pyroptosis to various cardiovascular diseases (CVDs) and their potential as a therapeutic target for preventing excessive cell death of myocardium during CVDs. |
| format | Article |
| id | doaj-art-7ba22838ad974a76b6cbf64342aaab2e |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-7ba22838ad974a76b6cbf64342aaab2e2025-02-03T06:00:47ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/254871254871Looking for Pyroptosis-Modulating miRNAs as a Therapeutic Target for Improving Myocardium SurvivalSeahyoung Lee0Eunhyun Choi1Min-Ji Cha2Ki-Chul Hwang3Institute for Bio-Medical Convergence, College of Medicine, Catholic Kwandong University, Gangneung-si, Gangwon-do 210-701, Republic of KoreaInstitute for Bio-Medical Convergence, College of Medicine, Catholic Kwandong University, Gangneung-si, Gangwon-do 210-701, Republic of KoreaInstitute for Bio-Medical Convergence, College of Medicine, Catholic Kwandong University, Gangneung-si, Gangwon-do 210-701, Republic of KoreaInstitute for Bio-Medical Convergence, College of Medicine, Catholic Kwandong University, Gangneung-si, Gangwon-do 210-701, Republic of KoreaPyroptosis is the most recently identified type of regulated cell death with inflammatory response and has characteristics distinct from those of apoptosis or necrosis. Recently, independent studies have reported that small noncoding RNAs termed microRNAs (miRNAs) are involved in the regulation of pyroptosis. Nevertheless, only a handful of empirical data regarding miRNA-dependent regulation of pyroptosis is currently available. This review is aimed to provide a current update on the role of miRNAs in pyroptosis and to offer suggestions for future studies probing miRNAs as a linker connecting pyroptosis to various cardiovascular diseases (CVDs) and their potential as a therapeutic target for preventing excessive cell death of myocardium during CVDs.http://dx.doi.org/10.1155/2015/254871 |
| spellingShingle | Seahyoung Lee Eunhyun Choi Min-Ji Cha Ki-Chul Hwang Looking for Pyroptosis-Modulating miRNAs as a Therapeutic Target for Improving Myocardium Survival Mediators of Inflammation |
| title | Looking for Pyroptosis-Modulating miRNAs as a Therapeutic Target for Improving Myocardium Survival |
| title_full | Looking for Pyroptosis-Modulating miRNAs as a Therapeutic Target for Improving Myocardium Survival |
| title_fullStr | Looking for Pyroptosis-Modulating miRNAs as a Therapeutic Target for Improving Myocardium Survival |
| title_full_unstemmed | Looking for Pyroptosis-Modulating miRNAs as a Therapeutic Target for Improving Myocardium Survival |
| title_short | Looking for Pyroptosis-Modulating miRNAs as a Therapeutic Target for Improving Myocardium Survival |
| title_sort | looking for pyroptosis modulating mirnas as a therapeutic target for improving myocardium survival |
| url | http://dx.doi.org/10.1155/2015/254871 |
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