Interactions between Myc and Mediators of Inflammation in Chronic Liver Diseases
Most chronic liver diseases (CLDs) are characterized by inflammatory processes with aberrant expressions of various pro- and anti-inflammatory mediators in the liver. These mediators are the driving force of many inflammatory liver disorders, which often result in fibrosis, cirrhosis, and liver tumo...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/276850 |
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| _version_ | 1832563713498939392 |
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| author | Ting Liu Yu Zhou Kwang Suk Ko Heping Yang |
| author_facet | Ting Liu Yu Zhou Kwang Suk Ko Heping Yang |
| author_sort | Ting Liu |
| collection | DOAJ |
| description | Most chronic liver diseases (CLDs) are characterized by inflammatory processes with aberrant expressions of various pro- and anti-inflammatory mediators in the liver. These mediators are the driving force of many inflammatory liver disorders, which often result in fibrosis, cirrhosis, and liver tumorigenesis. c-Myc is involved in many cellular events such as cell growth, proliferation, and differentiation. c-Myc upregulates IL-8, IL-10, TNF-α, and TGF-β, while IL-1, IL-2, IL-4, TNF-α, and TGF-β promote c-Myc expression. Their interactions play a central role in fibrosis, cirrhosis, and liver cancer. Molecular interference of their interactions offers possible therapeutic potential for CLDs. In this review, current knowledge of the molecular interactions between c-Myc and various well known inflammatory mediators is discussed. |
| format | Article |
| id | doaj-art-7b9ec5e18b624d4da776845ffb5e9c5a |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-7b9ec5e18b624d4da776845ffb5e9c5a2025-02-03T01:12:45ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/276850276850Interactions between Myc and Mediators of Inflammation in Chronic Liver DiseasesTing Liu0Yu Zhou1Kwang Suk Ko2Heping Yang3Department of Gastroenterology, Xiangya Hospital Central South University, 87 Xiangya Road, Changsha, Hunan 410008, ChinaGI Liver Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USADepartment of Nutritional Science and Food Management, College of Health Science, Ewha Womans University, Seoul 150-750, Republic of KoreaDivision of Gastroenterology, Department of Medicine, Cedars-Sinai Medical Center, Davis Building 2094A, 8700 Beverly Boulevard, Los Angeles, CA 90048, USAMost chronic liver diseases (CLDs) are characterized by inflammatory processes with aberrant expressions of various pro- and anti-inflammatory mediators in the liver. These mediators are the driving force of many inflammatory liver disorders, which often result in fibrosis, cirrhosis, and liver tumorigenesis. c-Myc is involved in many cellular events such as cell growth, proliferation, and differentiation. c-Myc upregulates IL-8, IL-10, TNF-α, and TGF-β, while IL-1, IL-2, IL-4, TNF-α, and TGF-β promote c-Myc expression. Their interactions play a central role in fibrosis, cirrhosis, and liver cancer. Molecular interference of their interactions offers possible therapeutic potential for CLDs. In this review, current knowledge of the molecular interactions between c-Myc and various well known inflammatory mediators is discussed.http://dx.doi.org/10.1155/2015/276850 |
| spellingShingle | Ting Liu Yu Zhou Kwang Suk Ko Heping Yang Interactions between Myc and Mediators of Inflammation in Chronic Liver Diseases Mediators of Inflammation |
| title | Interactions between Myc and Mediators of Inflammation in Chronic Liver Diseases |
| title_full | Interactions between Myc and Mediators of Inflammation in Chronic Liver Diseases |
| title_fullStr | Interactions between Myc and Mediators of Inflammation in Chronic Liver Diseases |
| title_full_unstemmed | Interactions between Myc and Mediators of Inflammation in Chronic Liver Diseases |
| title_short | Interactions between Myc and Mediators of Inflammation in Chronic Liver Diseases |
| title_sort | interactions between myc and mediators of inflammation in chronic liver diseases |
| url | http://dx.doi.org/10.1155/2015/276850 |
| work_keys_str_mv | AT tingliu interactionsbetweenmycandmediatorsofinflammationinchronicliverdiseases AT yuzhou interactionsbetweenmycandmediatorsofinflammationinchronicliverdiseases AT kwangsukko interactionsbetweenmycandmediatorsofinflammationinchronicliverdiseases AT hepingyang interactionsbetweenmycandmediatorsofinflammationinchronicliverdiseases |