Synthesis of Interleukin-10 in Patients with Ulcerative Colitis and Helicobacter pylori Infection
Background/Aims. Epidemiological evidence suggests a relationship between Helicobacter pylori infection with the development of autoimmune diseases. H. pylori elicit a chronic systemic inflammatory response with the secretion of proinflammatory cytokines. IL-10 is a regulatory cytokine that plays a...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2020/4171083 |
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| author | Jesús K. Yamamoto-Furusho Gabriela Fonseca-Camarillo Carlos A. Barrera-Ochoa Janette Furuzawa-Carballeda |
| author_facet | Jesús K. Yamamoto-Furusho Gabriela Fonseca-Camarillo Carlos A. Barrera-Ochoa Janette Furuzawa-Carballeda |
| author_sort | Jesús K. Yamamoto-Furusho |
| collection | DOAJ |
| description | Background/Aims. Epidemiological evidence suggests a relationship between Helicobacter pylori infection with the development of autoimmune diseases. H. pylori elicit a chronic systemic inflammatory response with the secretion of proinflammatory cytokines. IL-10 is a regulatory cytokine that plays a central role in limiting host immune response to pathogen. Increased IL-10 levels were reported in H. pylori–infected gastric mucosa. The aim of this study was to explore the relationship between IL-10 systemic synthesis and H. pylori infection in patients with ulcerative colitis. Methods. Detection of H. pylori infection was performed by a 13C-urea breath test in 31 patients with UC. In each patient, a serum sample was drawn to measure IL-10 by the ELISA technique. Based on the primary breath test result, two groups were formed and serum IL-10 was measured. Results. Serological IL-10 levels in patients with UC and negative 13C-urea breath test was 10.28 pg/ml whereas in patients with UC and positive 13C-urea breath test was 5.5 pg/ml (P=0.035). IL-10 levels were higher in the inflammatory endoscopic and histological active groups which tested positive in the 13C-urea breath tests for H. pylori (P<0.05).Conclusions. The role of IL-10 secretion in patients with UC in determining the clinicopathological outcome of infection merits further study. This study suggests an association between serum IL-10 and disease severity in patients with UC and HP infection. |
| format | Article |
| id | doaj-art-7b9a4907b6e64b1f8181e089049a643f |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-7b9a4907b6e64b1f8181e089049a643f2025-02-03T06:43:25ZengWileyGastroenterology Research and Practice1687-61211687-630X2020-01-01202010.1155/2020/41710834171083Synthesis of Interleukin-10 in Patients with Ulcerative Colitis and Helicobacter pylori InfectionJesús K. Yamamoto-Furusho0Gabriela Fonseca-Camarillo1Carlos A. Barrera-Ochoa2Janette Furuzawa-Carballeda3Inflammatory Bowel Disease Clinic, Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, 14080 Mexico City, MexicoInflammatory Bowel Disease Clinic, Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, 14080 Mexico City, MexicoInflammatory Bowel Disease Clinic, Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, 14080 Mexico City, MexicoDepartment of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán, Mexico City, MexicoBackground/Aims. Epidemiological evidence suggests a relationship between Helicobacter pylori infection with the development of autoimmune diseases. H. pylori elicit a chronic systemic inflammatory response with the secretion of proinflammatory cytokines. IL-10 is a regulatory cytokine that plays a central role in limiting host immune response to pathogen. Increased IL-10 levels were reported in H. pylori–infected gastric mucosa. The aim of this study was to explore the relationship between IL-10 systemic synthesis and H. pylori infection in patients with ulcerative colitis. Methods. Detection of H. pylori infection was performed by a 13C-urea breath test in 31 patients with UC. In each patient, a serum sample was drawn to measure IL-10 by the ELISA technique. Based on the primary breath test result, two groups were formed and serum IL-10 was measured. Results. Serological IL-10 levels in patients with UC and negative 13C-urea breath test was 10.28 pg/ml whereas in patients with UC and positive 13C-urea breath test was 5.5 pg/ml (P=0.035). IL-10 levels were higher in the inflammatory endoscopic and histological active groups which tested positive in the 13C-urea breath tests for H. pylori (P<0.05).Conclusions. The role of IL-10 secretion in patients with UC in determining the clinicopathological outcome of infection merits further study. This study suggests an association between serum IL-10 and disease severity in patients with UC and HP infection.http://dx.doi.org/10.1155/2020/4171083 |
| spellingShingle | Jesús K. Yamamoto-Furusho Gabriela Fonseca-Camarillo Carlos A. Barrera-Ochoa Janette Furuzawa-Carballeda Synthesis of Interleukin-10 in Patients with Ulcerative Colitis and Helicobacter pylori Infection Gastroenterology Research and Practice |
| title | Synthesis of Interleukin-10 in Patients with Ulcerative Colitis and Helicobacter pylori Infection |
| title_full | Synthesis of Interleukin-10 in Patients with Ulcerative Colitis and Helicobacter pylori Infection |
| title_fullStr | Synthesis of Interleukin-10 in Patients with Ulcerative Colitis and Helicobacter pylori Infection |
| title_full_unstemmed | Synthesis of Interleukin-10 in Patients with Ulcerative Colitis and Helicobacter pylori Infection |
| title_short | Synthesis of Interleukin-10 in Patients with Ulcerative Colitis and Helicobacter pylori Infection |
| title_sort | synthesis of interleukin 10 in patients with ulcerative colitis and helicobacter pylori infection |
| url | http://dx.doi.org/10.1155/2020/4171083 |
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