The Effect of Immunosuppressive Drugs on MDSCs in Transplantation
Myeloid-derived suppressor cells (MDSCs) are a group of innate immune cells that regulates both innate and adaptive immune responses. In recent years, MDSCs were shown to play an important negative regulatory role in transplant immunology even upstream of regulatory T cells. In certain cases, MDSCs...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/5414808 |
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| _version_ | 1832548551250411520 |
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| author | Fan Yang Yang Li Qian Zhang Liang Tan Longkai Peng Yong Zhao |
| author_facet | Fan Yang Yang Li Qian Zhang Liang Tan Longkai Peng Yong Zhao |
| author_sort | Fan Yang |
| collection | DOAJ |
| description | Myeloid-derived suppressor cells (MDSCs) are a group of innate immune cells that regulates both innate and adaptive immune responses. In recent years, MDSCs were shown to play an important negative regulatory role in transplant immunology even upstream of regulatory T cells. In certain cases, MDSCs are closely involved in transplantation immune tolerance induction and maintenance. It is known that some immunosuppressant drugs negatively regulate MDSCs but others have positive effects on MDSCs in different transplant cases. We herein summarized our recent insights into the regulatory roles of MDSCs in transplantation specially focusing on the effects of immunosuppressive drugs on MDSCs and their mechanisms of action. Studies on the effects of immunosuppressive drugs on MDSCs will significantly expand our understanding of immunosuppressive drugs on immune regulatory cells in transplantation and offer new insights into transplant tolerance. We hope to emphasize our concern for the negative effects of immunosuppressive agents on MDSCs, which may potentially attenuate the immune tolerance induction in transplanted recipients. |
| format | Article |
| id | doaj-art-7b7d937d65284c8d9da1e59b600d1743 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-7b7d937d65284c8d9da1e59b600d17432025-02-03T06:13:51ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/54148085414808The Effect of Immunosuppressive Drugs on MDSCs in TransplantationFan Yang0Yang Li1Qian Zhang2Liang Tan3Longkai Peng4Yong Zhao5State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, ChinaCenter of Organ Transplantation, Second Xiangya Hospital of Central South University, Changsha, ChinaCenter of Organ Transplantation, Second Xiangya Hospital of Central South University, Changsha, ChinaState Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, ChinaMyeloid-derived suppressor cells (MDSCs) are a group of innate immune cells that regulates both innate and adaptive immune responses. In recent years, MDSCs were shown to play an important negative regulatory role in transplant immunology even upstream of regulatory T cells. In certain cases, MDSCs are closely involved in transplantation immune tolerance induction and maintenance. It is known that some immunosuppressant drugs negatively regulate MDSCs but others have positive effects on MDSCs in different transplant cases. We herein summarized our recent insights into the regulatory roles of MDSCs in transplantation specially focusing on the effects of immunosuppressive drugs on MDSCs and their mechanisms of action. Studies on the effects of immunosuppressive drugs on MDSCs will significantly expand our understanding of immunosuppressive drugs on immune regulatory cells in transplantation and offer new insights into transplant tolerance. We hope to emphasize our concern for the negative effects of immunosuppressive agents on MDSCs, which may potentially attenuate the immune tolerance induction in transplanted recipients.http://dx.doi.org/10.1155/2018/5414808 |
| spellingShingle | Fan Yang Yang Li Qian Zhang Liang Tan Longkai Peng Yong Zhao The Effect of Immunosuppressive Drugs on MDSCs in Transplantation Journal of Immunology Research |
| title | The Effect of Immunosuppressive Drugs on MDSCs in Transplantation |
| title_full | The Effect of Immunosuppressive Drugs on MDSCs in Transplantation |
| title_fullStr | The Effect of Immunosuppressive Drugs on MDSCs in Transplantation |
| title_full_unstemmed | The Effect of Immunosuppressive Drugs on MDSCs in Transplantation |
| title_short | The Effect of Immunosuppressive Drugs on MDSCs in Transplantation |
| title_sort | effect of immunosuppressive drugs on mdscs in transplantation |
| url | http://dx.doi.org/10.1155/2018/5414808 |
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