The Clinical Trials of Mesenchymal Stromal Cells Therapy
Mesenchymal stromal cells (MSCs) are a heterogeneous population of adult stem cells, which are multipotent and possess the ability to differentiate/transdifferentiate into mesodermal and nonmesodermal cell lineages. MSCs display broad immunomodulatory properties since they are capable of secreting g...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2021/1634782 |
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| author | Mohammad Reza Kouchakian Neda Baghban Seyedeh Farzaneh Moniri Mandana Baghban Shabnam Bakhshalizadeh Vahid Najafzadeh Zahra Safaei Safoura Izanlou Arezoo Khoradmehr Iraj Nabipour Reza Shirazi Amin Tamadon |
| author_facet | Mohammad Reza Kouchakian Neda Baghban Seyedeh Farzaneh Moniri Mandana Baghban Shabnam Bakhshalizadeh Vahid Najafzadeh Zahra Safaei Safoura Izanlou Arezoo Khoradmehr Iraj Nabipour Reza Shirazi Amin Tamadon |
| author_sort | Mohammad Reza Kouchakian |
| collection | DOAJ |
| description | Mesenchymal stromal cells (MSCs) are a heterogeneous population of adult stem cells, which are multipotent and possess the ability to differentiate/transdifferentiate into mesodermal and nonmesodermal cell lineages. MSCs display broad immunomodulatory properties since they are capable of secreting growth factors and chemotactic cytokines. Safety, accessibility, and isolation from patients without ethical concern make MSCs valuable sources for cell therapy approaches in autoimmune, inflammatory, and degenerative diseases. Many studies have been conducted on the application of MSCs as a new therapy, but it seems that a low percentage of them is related to clinical trials, especially completed clinical trials. Considering the importance of clinical trials to develop this type of therapy as a new treatment, the current paper is aimed at describing characteristics of MSCs and reviewing relevant clinical studies registered on the NIH database during 2016-2020 to discuss recent advances on MSC-based therapeutic approaches being used in different diseases. |
| format | Article |
| id | doaj-art-7b7c59fb4f8b461bbc8628c87e2dbd7e |
| institution | Kabale University |
| issn | 1687-9678 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-7b7c59fb4f8b461bbc8628c87e2dbd7e2025-02-03T01:04:38ZengWileyStem Cells International1687-96782021-01-01202110.1155/2021/1634782The Clinical Trials of Mesenchymal Stromal Cells TherapyMohammad Reza Kouchakian0Neda Baghban1Seyedeh Farzaneh Moniri2Mandana Baghban3Shabnam Bakhshalizadeh4Vahid Najafzadeh5Zahra Safaei6Safoura Izanlou7Arezoo Khoradmehr8Iraj Nabipour9Reza Shirazi10Amin Tamadon11Department of Anatomical SciencesThe Persian Gulf Marine Biotechnology Research CenterDepartment of Anatomical SciencesDepartment of Obstetrics and GynecologyReproductive DevelopmentDepartment of Veterinary and Animal SciencesDepartment of Obstetrics and GynecologyDepartment of NursingThe Persian Gulf Marine Biotechnology Research CenterThe Persian Gulf Marine Biotechnology Research CenterDepartment of AnatomyThe Persian Gulf Marine Biotechnology Research CenterMesenchymal stromal cells (MSCs) are a heterogeneous population of adult stem cells, which are multipotent and possess the ability to differentiate/transdifferentiate into mesodermal and nonmesodermal cell lineages. MSCs display broad immunomodulatory properties since they are capable of secreting growth factors and chemotactic cytokines. Safety, accessibility, and isolation from patients without ethical concern make MSCs valuable sources for cell therapy approaches in autoimmune, inflammatory, and degenerative diseases. Many studies have been conducted on the application of MSCs as a new therapy, but it seems that a low percentage of them is related to clinical trials, especially completed clinical trials. Considering the importance of clinical trials to develop this type of therapy as a new treatment, the current paper is aimed at describing characteristics of MSCs and reviewing relevant clinical studies registered on the NIH database during 2016-2020 to discuss recent advances on MSC-based therapeutic approaches being used in different diseases.http://dx.doi.org/10.1155/2021/1634782 |
| spellingShingle | Mohammad Reza Kouchakian Neda Baghban Seyedeh Farzaneh Moniri Mandana Baghban Shabnam Bakhshalizadeh Vahid Najafzadeh Zahra Safaei Safoura Izanlou Arezoo Khoradmehr Iraj Nabipour Reza Shirazi Amin Tamadon The Clinical Trials of Mesenchymal Stromal Cells Therapy Stem Cells International |
| title | The Clinical Trials of Mesenchymal Stromal Cells Therapy |
| title_full | The Clinical Trials of Mesenchymal Stromal Cells Therapy |
| title_fullStr | The Clinical Trials of Mesenchymal Stromal Cells Therapy |
| title_full_unstemmed | The Clinical Trials of Mesenchymal Stromal Cells Therapy |
| title_short | The Clinical Trials of Mesenchymal Stromal Cells Therapy |
| title_sort | clinical trials of mesenchymal stromal cells therapy |
| url | http://dx.doi.org/10.1155/2021/1634782 |
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