Comparison of Newly Diagnosed Ocular Hypertension and Open-Angle Glaucoma: Ocular Variables, Risk Factors, and Disease Severity
Purpose. To describe the distribution of ocular variables, risk factors, and disease severity in newly diagnosed ocular hypertension (OH) or open-angle glaucoma (OAG). Methods. Eligible subjects underwent a complete history and examination. Adjusted odds ratios (ORs) and 95% confidence intervals (...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2012/757106 |
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| author | Yvonne M. Buys Paul Harasymowycz Rania Gaspo Kenneth Kwok Cindy M. L. Hutnik Pierre Blondeau Catherine M. Birt Robert L. G. Piemontesi Lisa F. Gould Mark R. Lesk Iqbal K. Ahmed |
| author_facet | Yvonne M. Buys Paul Harasymowycz Rania Gaspo Kenneth Kwok Cindy M. L. Hutnik Pierre Blondeau Catherine M. Birt Robert L. G. Piemontesi Lisa F. Gould Mark R. Lesk Iqbal K. Ahmed |
| author_sort | Yvonne M. Buys |
| collection | DOAJ |
| description | Purpose. To describe the distribution of ocular variables, risk factors, and disease severity in newly diagnosed ocular hypertension (OH) or open-angle glaucoma (OAG).
Methods. Eligible subjects underwent a complete history and examination. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) obtained from multiple logistic regression models were used to compare OAG to OH and advanced to early/moderate OAG.
Results. 405 subjects were enrolled: 292 (72.1%) with OAG and 113 (27.9%) with OH. 51.7% had early, 27.1% moderate, and 20.9% advanced OAG. The OR for OAG versus OH was 8.19 (P<0.0001) for disc notch, 5.36 (P<0.0001) for abnormal visual field, 1.45 (P=0.001) for worsening mean deviation, 1.91 (P<0.0001) for increased cupping, 1.03 for increased age (P=0.030), and 0.36 (P=0.010) for smoking.
Conclusions. Increased age was a risk for OAG, and smoking decreased the risk of OAG compared to OH. Almost half of the OAG subjects had moderate/advanced disease at diagnosis. |
| format | Article |
| id | doaj-art-7b73e16fd7fb44b5b13edef9c03813a3 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-7b73e16fd7fb44b5b13edef9c03813a32025-02-03T05:46:45ZengWileyJournal of Ophthalmology2090-004X2090-00582012-01-01201210.1155/2012/757106757106Comparison of Newly Diagnosed Ocular Hypertension and Open-Angle Glaucoma: Ocular Variables, Risk Factors, and Disease SeverityYvonne M. Buys0Paul Harasymowycz1Rania Gaspo2Kenneth Kwok3Cindy M. L. Hutnik4Pierre Blondeau5Catherine M. Birt6Robert L. G. Piemontesi7Lisa F. Gould8Mark R. Lesk9Iqbal K. Ahmed10Department of Ophthalmology, University of Toronto, 399 Bathurst Street, EW 6-405, Toronto, ON, M5T 2S8, CanadaDepartment of Ophthalmology, University of Montreal, Montréal, QC, H3T 1J4, CanadaMedical Advisor - Oncology, Pfizer Canada Inc., Kirkland, QC, H3C 3J7, CanadaBiostatistics, Pfizer Inc., New York, NY 10017, USAIvey Eye Institute, St. Joseph's Health Care London, London, ON, N6G 1J1, CanadaDepartment of Ophthalmology, University of Sherbrooke, Sherbrooke, QC, J1K 2R1, CanadaDepartment of Ophthalmology, University of Toronto, 399 Bathurst Street, EW 6-405, Toronto, ON, M5T 2S8, CanadaDepartment of Ophthalmology, Naniamo, British Columbia, V9R 5B6, CanadaThe Winnipeg Clinic, Winnipeg, MB, R3C ON2, CanadaDepartment of Ophthalmology, Hopital Maisonneuve-Rosemont, Montréal, QC, H1T 2M4, CanadaDepartment of Ophthalmology, University of Toronto, 399 Bathurst Street, EW 6-405, Toronto, ON, M5T 2S8, CanadaPurpose. To describe the distribution of ocular variables, risk factors, and disease severity in newly diagnosed ocular hypertension (OH) or open-angle glaucoma (OAG). Methods. Eligible subjects underwent a complete history and examination. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) obtained from multiple logistic regression models were used to compare OAG to OH and advanced to early/moderate OAG. Results. 405 subjects were enrolled: 292 (72.1%) with OAG and 113 (27.9%) with OH. 51.7% had early, 27.1% moderate, and 20.9% advanced OAG. The OR for OAG versus OH was 8.19 (P<0.0001) for disc notch, 5.36 (P<0.0001) for abnormal visual field, 1.45 (P=0.001) for worsening mean deviation, 1.91 (P<0.0001) for increased cupping, 1.03 for increased age (P=0.030), and 0.36 (P=0.010) for smoking. Conclusions. Increased age was a risk for OAG, and smoking decreased the risk of OAG compared to OH. Almost half of the OAG subjects had moderate/advanced disease at diagnosis.http://dx.doi.org/10.1155/2012/757106 |
| spellingShingle | Yvonne M. Buys Paul Harasymowycz Rania Gaspo Kenneth Kwok Cindy M. L. Hutnik Pierre Blondeau Catherine M. Birt Robert L. G. Piemontesi Lisa F. Gould Mark R. Lesk Iqbal K. Ahmed Comparison of Newly Diagnosed Ocular Hypertension and Open-Angle Glaucoma: Ocular Variables, Risk Factors, and Disease Severity Journal of Ophthalmology |
| title | Comparison of Newly Diagnosed Ocular Hypertension and Open-Angle Glaucoma: Ocular Variables, Risk Factors, and Disease Severity |
| title_full | Comparison of Newly Diagnosed Ocular Hypertension and Open-Angle Glaucoma: Ocular Variables, Risk Factors, and Disease Severity |
| title_fullStr | Comparison of Newly Diagnosed Ocular Hypertension and Open-Angle Glaucoma: Ocular Variables, Risk Factors, and Disease Severity |
| title_full_unstemmed | Comparison of Newly Diagnosed Ocular Hypertension and Open-Angle Glaucoma: Ocular Variables, Risk Factors, and Disease Severity |
| title_short | Comparison of Newly Diagnosed Ocular Hypertension and Open-Angle Glaucoma: Ocular Variables, Risk Factors, and Disease Severity |
| title_sort | comparison of newly diagnosed ocular hypertension and open angle glaucoma ocular variables risk factors and disease severity |
| url | http://dx.doi.org/10.1155/2012/757106 |
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