High-Intensity Aerobic Exercise Prevents Angiotensin II-Induced Muscle Atrophy
Purpose Angiotensin II (Ang II) is widely recognized as a primary factor in the development of hypertension; however, recent research also implicates it in skeletal muscle damage and atrophy. The precise mechanisms by which Ang II impacts muscle morphology and the molecular pathways related to atrop...
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Korean Continence Society
2025-07-01
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| Series: | International Neurourology Journal |
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| Online Access: | http://einj.org/upload/pdf/inj-2550150-075.pdf |
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| author | Jong-Hwa Won Ying-Ying Xiang Kyung-Wan Baek Min-Jeong Kang Ji-Seok Kim |
| author_facet | Jong-Hwa Won Ying-Ying Xiang Kyung-Wan Baek Min-Jeong Kang Ji-Seok Kim |
| author_sort | Jong-Hwa Won |
| collection | DOAJ |
| description | Purpose Angiotensin II (Ang II) is widely recognized as a primary factor in the development of hypertension; however, recent research also implicates it in skeletal muscle damage and atrophy. The precise mechanisms by which Ang II impacts muscle morphology and the molecular pathways related to atrophy remain unclear. Moreover, the potential protective effects of aerobic exercise against Ang II-induced muscle alterations have not been fully elucidated. This study aimed to investigate the effects of Ang II on skeletal muscle structure and atrophy-related molecular markers and to assess whether aerobic exercise can confer protective effects against these changes in an Ang II-induced animal model. Methods Six-week-old mice (n =48) were divided into 4 groups: (1) control (CON, n =12), (2) Ang II (n =12), (3) Ang II plus low-intensity exercise (Ang II+LIE, n=12), and (4) Ang II plus high-intensity exercise (Ang II+HIE, n=12). Ang II was administered subcutaneously once daily for 4 weeks (1.4 mg/kg/day in phosphate-buffered saline, pH 7.2). The Ang II+LIE and Ang II+HIE groups received daily Ang II injections along with their respective exercise protocols for 4 weeks. Results The protein expression of inflammatory factors was significantly reduced in the Ang II+HIE group compared to the Ang II group (P < 0.05). Furthermore, the expression of muscle protein synthesis markers, including insulin-like growth factor 1, AKT, mammalian target of rapamycin, and S6K1, was significantly higher in the exercise groups than in the Ang II group (P<0.05). Notably, the expression of autophagy-related factors was also significantly elevated in the Ang II+HIE group compared to the Ang II group (P < 0.05). Conclusions Ang II-induced muscle atrophy was attenuated by aerobic exercise. |
| format | Article |
| id | doaj-art-7b4c2ad996d040d1b86612f589e2f89c |
| institution | Kabale University |
| issn | 2093-4777 2093-6931 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Korean Continence Society |
| record_format | Article |
| series | International Neurourology Journal |
| spelling | doaj-art-7b4c2ad996d040d1b86612f589e2f89c2025-08-20T03:34:30ZengKorean Continence SocietyInternational Neurourology Journal2093-47772093-69312025-07-0129Suppl 1S44S5210.5213/inj.2550150.0751170High-Intensity Aerobic Exercise Prevents Angiotensin II-Induced Muscle AtrophyJong-Hwa Won0Ying-Ying Xiang1Kyung-Wan Baek2Min-Jeong Kang3Ji-Seok Kim4 Department of Physical Education, Gyeongsang National University, Jinju, Korea Department of Physical Education, Gyeongsang National University, Jinju, Korea Department of Physical Education, Gyeongsang National University, Jinju, Korea Department of Physical Education, Gyeongsang National University, Jinju, Korea Department of Physical Education, Gyeongsang National University, Jinju, KoreaPurpose Angiotensin II (Ang II) is widely recognized as a primary factor in the development of hypertension; however, recent research also implicates it in skeletal muscle damage and atrophy. The precise mechanisms by which Ang II impacts muscle morphology and the molecular pathways related to atrophy remain unclear. Moreover, the potential protective effects of aerobic exercise against Ang II-induced muscle alterations have not been fully elucidated. This study aimed to investigate the effects of Ang II on skeletal muscle structure and atrophy-related molecular markers and to assess whether aerobic exercise can confer protective effects against these changes in an Ang II-induced animal model. Methods Six-week-old mice (n =48) were divided into 4 groups: (1) control (CON, n =12), (2) Ang II (n =12), (3) Ang II plus low-intensity exercise (Ang II+LIE, n=12), and (4) Ang II plus high-intensity exercise (Ang II+HIE, n=12). Ang II was administered subcutaneously once daily for 4 weeks (1.4 mg/kg/day in phosphate-buffered saline, pH 7.2). The Ang II+LIE and Ang II+HIE groups received daily Ang II injections along with their respective exercise protocols for 4 weeks. Results The protein expression of inflammatory factors was significantly reduced in the Ang II+HIE group compared to the Ang II group (P < 0.05). Furthermore, the expression of muscle protein synthesis markers, including insulin-like growth factor 1, AKT, mammalian target of rapamycin, and S6K1, was significantly higher in the exercise groups than in the Ang II group (P<0.05). Notably, the expression of autophagy-related factors was also significantly elevated in the Ang II+HIE group compared to the Ang II group (P < 0.05). Conclusions Ang II-induced muscle atrophy was attenuated by aerobic exercise.http://einj.org/upload/pdf/inj-2550150-075.pdfmuscle atrophyangiotensin iiaerobic exerciseautophagy |
| spellingShingle | Jong-Hwa Won Ying-Ying Xiang Kyung-Wan Baek Min-Jeong Kang Ji-Seok Kim High-Intensity Aerobic Exercise Prevents Angiotensin II-Induced Muscle Atrophy International Neurourology Journal muscle atrophy angiotensin ii aerobic exercise autophagy |
| title | High-Intensity Aerobic Exercise Prevents Angiotensin II-Induced Muscle Atrophy |
| title_full | High-Intensity Aerobic Exercise Prevents Angiotensin II-Induced Muscle Atrophy |
| title_fullStr | High-Intensity Aerobic Exercise Prevents Angiotensin II-Induced Muscle Atrophy |
| title_full_unstemmed | High-Intensity Aerobic Exercise Prevents Angiotensin II-Induced Muscle Atrophy |
| title_short | High-Intensity Aerobic Exercise Prevents Angiotensin II-Induced Muscle Atrophy |
| title_sort | high intensity aerobic exercise prevents angiotensin ii induced muscle atrophy |
| topic | muscle atrophy angiotensin ii aerobic exercise autophagy |
| url | http://einj.org/upload/pdf/inj-2550150-075.pdf |
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