Single-cell transcriptomics identify a novel macrophage population associated with bone invasion in pituitary neuroendocrine tumors

Single-cell transcriptomics identify a novel macrophage population associated with bone invasion in pituitary neuroendocrine tumors

Abstract Background Bone-invasive Pituitary Neuroendocrine Tumors (BI PitNETs) epitomize an aggressive subtype of pituitary tumors characterized by bone invasion, culminating in extensive skull base bone destruction and fragmentation. This infiltration poses a significant surgical risk due to potent...

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Bibliographic Details
Main Authors: Xinzhi Wu, Xueshuai Han, Haibo Zhu, Mingxuan Li, Lei Gong, Sicheng Jing, Weiyan Xie, Zhaoqi Liu, Chuzhong Li, Yazhuo Zhang
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
PitNETs
Bone invasion
TAM
TNF-α
Macrophage
Online Access:https://doi.org/10.1186/s13046-025-03296-9
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