Functional Evaluation of the Visual Pathway in Patients with Multiple Sclerosis Using a Multifunction Stimulator Monitor
Objectives. To assess the capability of the vision monitor unit Monpack One of detecting visual function alterations in patients with multiple sclerosis (MS) and to evaluate the correlation between structural retinal parameters and functional measurements obtained with this device. Methods. Forty-ei...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2019/2890193 |
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| author | M. Satue L. Jarauta J. Obis M. Cipres M. J. Rodrigo C. Almarcegui I. Dolz J. R. Ara J. Martin L. E. Pablo E. Garcia-Martin |
| author_facet | M. Satue L. Jarauta J. Obis M. Cipres M. J. Rodrigo C. Almarcegui I. Dolz J. R. Ara J. Martin L. E. Pablo E. Garcia-Martin |
| author_sort | M. Satue |
| collection | DOAJ |
| description | Objectives. To assess the capability of the vision monitor unit Monpack One of detecting visual function alterations in patients with multiple sclerosis (MS) and to evaluate the correlation between structural retinal parameters and functional measurements obtained with this device. Methods. Forty-eight patients with MS and 46 healthy controls were included in a cross-sectional study. All participants underwent a complete functional evaluation of the visual pathway, which included low-contrast visual acuity (LCVA), contrast sensitivity vision (CSV), automated perimetry, multifocal visual evoked potentials (mfVEPs), and pattern electroretinogram (ERG). All tests were performed using the vision monitor unit Monpack One (Metrovision, France), a multifunction stimulator device. Retinal structural measurements were obtained in all subjects using Triton swept source optical coherence tomography (Topcon, Japan). Results. Patients with MS presented reduced low-contrast VA (p<0.001) and reduced CSV at medium (p=0.001, p=0.013) and low (p=0.001, p=0.002) spatial frequencies. All visual field parameters were found to be altered in MS patients compared with controls (≤0.001). Patients with MS presented lower amplitude of the P100 waveform of the mfVEP in areas corresponding to central (p<0.001), inferonasal (p=0.001), and inferotemporal (p=0.003) retina. The pattern ERG did not show significant differences. Significant correlations were observed between structural retinal measurements and functional parameters, especially between the inner macular areas and measurements corresponding to contrast sensitivity and perimetry indexes. Conclusions. Patients with MS present visual dysfunction detectable with the vision monitor unit Monpack One. This device may be a fast and useful tool to provide a full evaluation of axonal damage in patients with multiple sclerosis. |
| format | Article |
| id | doaj-art-7b465b387a4247e0a1c900a31f110926 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-7b465b387a4247e0a1c900a31f1109262025-02-03T00:59:23ZengWileyJournal of Ophthalmology2090-004X2090-00582019-01-01201910.1155/2019/28901932890193Functional Evaluation of the Visual Pathway in Patients with Multiple Sclerosis Using a Multifunction Stimulator MonitorM. Satue0L. Jarauta1J. Obis2M. Cipres3M. J. Rodrigo4C. Almarcegui5I. Dolz6J. R. Ara7J. Martin8L. E. Pablo9E. Garcia-Martin10Ophthalmology Department, Miguel Servet University Hospital, Zaragoza, SpainNeurology Department, Miguel Servet University Hospital, Zaragoza, SpainOphthalmology Department, Miguel Servet University Hospital, Zaragoza, SpainOphthalmology Department, Miguel Servet University Hospital, Zaragoza, SpainOphthalmology Department, Miguel Servet University Hospital, Zaragoza, SpainIIS-Aragon, Aragon Health Research Institute, Zaragoza, SpainIIS-Aragon, Aragon Health Research Institute, Zaragoza, SpainIIS-Aragon, Aragon Health Research Institute, Zaragoza, SpainIIS-Aragon, Aragon Health Research Institute, Zaragoza, SpainOphthalmology Department, Miguel Servet University Hospital, Zaragoza, SpainOphthalmology Department, Miguel Servet University Hospital, Zaragoza, SpainObjectives. To assess the capability of the vision monitor unit Monpack One of detecting visual function alterations in patients with multiple sclerosis (MS) and to evaluate the correlation between structural retinal parameters and functional measurements obtained with this device. Methods. Forty-eight patients with MS and 46 healthy controls were included in a cross-sectional study. All participants underwent a complete functional evaluation of the visual pathway, which included low-contrast visual acuity (LCVA), contrast sensitivity vision (CSV), automated perimetry, multifocal visual evoked potentials (mfVEPs), and pattern electroretinogram (ERG). All tests were performed using the vision monitor unit Monpack One (Metrovision, France), a multifunction stimulator device. Retinal structural measurements were obtained in all subjects using Triton swept source optical coherence tomography (Topcon, Japan). Results. Patients with MS presented reduced low-contrast VA (p<0.001) and reduced CSV at medium (p=0.001, p=0.013) and low (p=0.001, p=0.002) spatial frequencies. All visual field parameters were found to be altered in MS patients compared with controls (≤0.001). Patients with MS presented lower amplitude of the P100 waveform of the mfVEP in areas corresponding to central (p<0.001), inferonasal (p=0.001), and inferotemporal (p=0.003) retina. The pattern ERG did not show significant differences. Significant correlations were observed between structural retinal measurements and functional parameters, especially between the inner macular areas and measurements corresponding to contrast sensitivity and perimetry indexes. Conclusions. Patients with MS present visual dysfunction detectable with the vision monitor unit Monpack One. This device may be a fast and useful tool to provide a full evaluation of axonal damage in patients with multiple sclerosis.http://dx.doi.org/10.1155/2019/2890193 |
| spellingShingle | M. Satue L. Jarauta J. Obis M. Cipres M. J. Rodrigo C. Almarcegui I. Dolz J. R. Ara J. Martin L. E. Pablo E. Garcia-Martin Functional Evaluation of the Visual Pathway in Patients with Multiple Sclerosis Using a Multifunction Stimulator Monitor Journal of Ophthalmology |
| title | Functional Evaluation of the Visual Pathway in Patients with Multiple Sclerosis Using a Multifunction Stimulator Monitor |
| title_full | Functional Evaluation of the Visual Pathway in Patients with Multiple Sclerosis Using a Multifunction Stimulator Monitor |
| title_fullStr | Functional Evaluation of the Visual Pathway in Patients with Multiple Sclerosis Using a Multifunction Stimulator Monitor |
| title_full_unstemmed | Functional Evaluation of the Visual Pathway in Patients with Multiple Sclerosis Using a Multifunction Stimulator Monitor |
| title_short | Functional Evaluation of the Visual Pathway in Patients with Multiple Sclerosis Using a Multifunction Stimulator Monitor |
| title_sort | functional evaluation of the visual pathway in patients with multiple sclerosis using a multifunction stimulator monitor |
| url | http://dx.doi.org/10.1155/2019/2890193 |
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